Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Dana-Farber Cancer Institute
Study ID
NCT06026111
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • High-Intensity Interval Training (HIIT) — BEHAVIORAL
    Home-based, virtually supervised, aerobic exercise intervention at a high intensity in an interval fashion.
  • Moderate-Intensity Continuous Training (MICT) — BEHAVIORAL
    Home-based, virtually supervised, aerobic exercise intervention at a moderate intensity in a continuous fashion.

Study Details

The purpose of this study is to examine the feasibility and effects of 12-week exercise training at different intensities among individuals with advanced lung cancer receiving immune checkpoint inhibitors. The names of the study interventions involved in this study are:

Key Dates

Start date
Feb 1, 2024
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: High-Intensity Interval Training (HIIT)
    Patients in the HIIT group will perform alternating vigorous-intensity and recovery aerobic exercise intervals on a provided home stationary bike. The HIIT protocol consists of alternating a high-intensity exercise phase (1 min at 65-90% of workload corresponding to VO2peak) and a recovery phase (1 min at 30%), and the high-intensity and recovery intervals will be repeated 5-10 times in each session.
  • Experimental: Moderate-Intensity Continuous Training (MICT)
    The MICT group will perform an aerobic exercise at a continuous intensity in each session on a stationary bike. Similar to HIIT, the intensity will be progressed (47.5-60%). The total work of MICT is equalized with HIIT for training volume and frequency to compare the differences exerted from different intensities and energy expenditure.
  • No Intervention: Usual Care (UC)
    Participants will be asked to maintain their baseline exercise behavior.

Primary Outcome Measure

Proportion of Participants completing the exercise intervention sessions [ Time Frame: Up to 14 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Dana-Farber Cancer InstituteBostonMassachusetts02215
Christina Dieli-Conwright, PhD, MPH
[email protected]
617-582-8321
Christina Dieli-Conwright, PhD, MPH (PRINCIPAL_INVESTIGATOR)

Find similar trials in Boston, MA

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Dana-Farber Cancer Institute· Boston, MA

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