Paid Clinical Trials in Massachusetts

Massachusetts has 3,586 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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First In Human Study of CX-2051 in Advanced Solid Tumors

for Solid Tumor, Adult

7 locations incl. Denver

Sponsor: CytomX Therapeutics

Sex: All·Age: 18+

Code: NCT06265688·Phase 1·Recruiting

Apply to this trial

A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD

for Neovascular (Wet) Age-related Macular Degeneration

3 locations incl. Boston

Sponsor: Skyline Therapeutics

Sex: All·Age: 50+

Code: NCT06346600·Recruiting

Apply to this trial

Impulsivity Domains and Subjective Response

for Alcohol Use Disorder

2 locations incl. Boston

Sponsor: Jessica Weafer

Sex: All·Age: 21 - 25·Accepts healthy volunteers

Code: NCT05929677·EARLY_Phase 1·Recruiting

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Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

for Chronic Obstructive Pulmonary Disease

5 locations incl. Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 35 - 89

Code: NCT05937854·Phase 2·Recruiting

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Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

for HIV-1-infection

10 locations incl. San Diego

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06071767·Phase 1, Phase 2·Recruiting

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Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan

for Prostate Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT06099093·Phase 4·Recruiting

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A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion

for Immunoglobulin Light Chain (AL) Amyloidosis

Drug: Etentamig

12 locations incl. Miami

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06158854·Phase 1, Phase 2·Recruiting

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Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis

for Cystic Fibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 13 - 20·Accepts healthy volunteers

Code: NCT06216704·Recruiting

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Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer

for Prostate Cancer

44 locations incl. Homewood

Sponsor: Curium US LLC

Sex: Male·Age: 18+

Code: NCT06235151·Phase 3·Recruiting

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A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors

for Solid Tumor, Adult

15 locations incl. Birmingham

Sponsor: Corbus Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06265727·Phase 1, Phase 2·Recruiting

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Digital Health Navigation for Latino Patients With Type II Diabetes

for Type 2 Diabetes

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06283992·Recruiting

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Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

for Immunoglobulin A Nephropathy

46 locations incl. Alabaster

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06291376·Phase 3·Recruiting

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An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

for Stargardt

14 locations incl. San Diego

Sponsor: Splice Bio

Sex: All·Age: 12 - 65

Code: NCT06435000·Recruiting

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A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

for Multiple Sclerosis

17 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18 - 60

Code: NCT06220201·Phase 1·Recruiting

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Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)

for Breast Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18 - 59·Accepts healthy volunteers

Code: NCT06322888·Recruiting

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Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA

for OSA

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 80

Code: NCT06091098·Recruiting

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Promoting Shared Decision Making for Severe Aortic Stenosis

for Aortic Stenosis

8 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65 - 85

Code: NCT06171737·Enrolling By Invitation

A Study of Participants With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel

for Cerebral Adrenoleukodystrophy (CALD)

3 locations incl. Boston

Sponsor: Genetix Biotherapeutics Inc.

Sex: Male·Age: All ages

Code: NCT06224413·Recruiting

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NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for Adipocytic Neoplasm

Drug: Selinexor

7 locations incl. Atlanta

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 30

Code: NCT06239272·Phase 1, Phase 2·Recruiting

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A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk

for Relapsing Multiple Sclerosis

5 locations incl. San Francisco

Sponsor: TG Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT06143514·Recruiting

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Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

for Arrhythmogenic Right Ventricular Cardiomyopathy

7 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06228924·Phase 1·Recruiting

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Preventing Depression of Chinese American Adolescents by RRE

for Subclinical Depressive Symptoms

1 location in Boston

Sponsor: Northeastern University

Sex: All·Age: 14 - 18·Accepts healthy volunteers

Code: NCT05921201·Recruiting

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The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

for Polycystic Ovary Syndrome

24 locations incl. Encino

Sponsor: May Health

Sex: Female·Age: 18 - 40

Code: NCT06206746·Recruiting

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A Phase 1/1b Study of IAM1363 in HER2 Cancers

for HER2 Mutation-Related Tumors

29 locations incl. La Jolla

Sponsor: Iambic Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06253871·Phase 1·Recruiting

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Medical Illustration Design Characteristic Evaluation

for Healthy

2 locations incl. Boston

Sponsor: Northeastern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06435806·Recruiting

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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

for Anxiety Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 19

Code: NCT05962879·Recruiting

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

18 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting

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COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

for Colorectal Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05692024·Phase 1, Phase 2·Recruiting

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The Osteoarthritis Prevention Study

for Osteoarthritis, Knee

3 locations incl. Boston

Sponsor: Wake Forest University

Sex: Female·Age: 50+·Accepts healthy volunteers

Code: NCT05946044·Recruiting

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A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

for Neoplasms, Head and Neck

Drug: Dostarlimab

36 locations incl. Jonesboro

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06256588·Phase 3·Recruiting

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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

41 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06297226·Phase 2·Recruiting

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Expressive Writing on Minority Stressors Among Sexual Minority Veterans

for Depressive Symptoms

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05897021·Recruiting

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VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study

for Crohn's Disease

12 locations incl. Sun City

Sponsor: Alimentiv Inc.

Sex: All·Age: 18+

Code: NCT06249555·Recruiting

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Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD

for Attention-Deficit/Hyperactivity Disorder

47 locations incl. Saraland

Sponsor: Supernus Pharmaceuticals, Inc.

Sex: All·Age: 48 Months - 69 Months

Code: NCT04781140·Phase 4·Recruiting

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A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

for Non Small Cell Lung Cancer

9 locations incl. Margate

Sponsor: Compass Therapeutics

Sex: All·Age: 18+

Code: NCT06150664·Phase 1·Recruiting

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Strategy for Improving Stroke Treatment Response

for Ischemic Stroke

52 locations incl. Birmingham

Sponsor: Translational Sciences, Inc.

Sex: All·Age: 18+

Code: NCT05948566·Phase 2·Recruiting

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ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

for Aortic Valve Stenosis

67 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT05932615·Enrolling By Invitation

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

for Crohn's Disease

15 locations incl. Los Angeles

Sponsor: Eli Lilly and Company

Sex: All·Age: 2 - 17

Code: NCT05509777·Phase 3·Recruiting

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A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Guselkumab

14 locations incl. Los Angeles

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 2 - 17

Code: NCT05923073·Phase 3·Recruiting

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Optimizing Surgical Decisions in Young Adults With Breast Cancer

for Breast Cancer Stage 0

4 locations incl. New Haven

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18 - 44

Code: NCT06275126·Recruiting

Apply to this trial