Paid Clinical Trials in Massachusetts

Massachusetts has 3,587 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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3,587 clinical trials

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Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

for Non-Small Cell Lung Cancer

28 locations incl. Irvine

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07100080·Phase 2, Phase 3·Recruiting

Apply to this trial

Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

for Nursing Home Resident

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07220486·Recruiting

Apply to this trial

ACT Lung Health Intervention: Phase Two

for Smoking Cessation

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06945120·Recruiting

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Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking

for Repetitive Negative Thinking

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 13 - 21·Accepts healthy volunteers

Code: NCT07055217·Recruiting

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The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project

for Burnout, Professional

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07221422·Recruiting

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Mirai-MRI: Validation of AI Models for Breast Cancer Risk

for Cancer Risk

4 locations incl. San Diego

Sponsor: University of California, San Francisco

Sex: Female·Age: 40 - 89·Accepts healthy volunteers

Code: NCT07121972·Recruiting

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Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults

for COVID-19

2 locations incl. Colorado Springs

Sponsor: CastleVax Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07215520·Phase 2·Recruiting

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De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia

for Congenital Diaphragmatic Hernia

19 locations incl. Birmingham

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 Months - 1 Month

Code: NCT05213676·Phase 4·Recruiting

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SLN Mapping and ICG Dye for Vulvar Cancer

for Vulva Cancer

1 location in Boston

Sponsor: Tufts Medical Center

Sex: Female·Age: 18+

Code: NCT06035068·Not Yet Recruiting

CCM OPEN HF Registry

for Heart Failure

28 locations incl. Mesa

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT07112924·Recruiting

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SAINT in Postpartum Depression (PPD)

for Postpartum Depression (PPD)

4 locations incl. Worcester

Sponsor: Magnus Medical

Sex: Female·Age: 18 - 45

Code: NCT07210255·Recruiting

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Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.

for Infertility (IVF Patients)

16 locations incl. Encino

Sponsor: Granata Bio Corporation

Sex: Female·Age: 18 - 42

Code: NCT07216742·Phase 3·Recruiting

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I-DECIDE After Bronchiolitis Hospitalization

for Bronchiolitis Acute

56 locations incl. Birmingham

Sponsor: Seattle Children's Hospital

Sex: All·Age: 0 Months - 24 Months

Code: NCT07243652·Recruiting

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Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

for Amputation

2 locations incl. Chicago

Sponsor: Liberating Technologies, Inc.

Sex: All·Age: 18+

Code: NCT07011420·Recruiting

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Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

for Fibromyalgia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT07023523·Recruiting

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A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

for Uncontrolled Hypertension

20 locations incl. San Jose

Sponsor: Retension Pharmaceuticals. Inc.

Sex: All·Age: 18 - 70

Code: NCT07142356·Phase 2·Recruiting

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An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

for Dry Eye

5 locations incl. Newport Beach

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07179055·Phase 2·Recruiting

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Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial

for Critical Illness

1 location in Boston

Sponsor: Wandercraft

Sex: All·Age: 18+

Code: NCT07220733·Phase 1, Phase 2·Recruiting

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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

50 locations incl. Chandler

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting

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Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

for Opioid Use Disorder

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06732596·Recruiting

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Optimizing Care Transition Process for Older Colorectal Surgery Patients

for Colorectal Surgery

1 location in Salem

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT06752031·Recruiting

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A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

for Eosinophilic Esophagitis

41 locations incl. Little Rock

Sponsor: Phathom Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06851559·Phase 2·Recruiting

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Well-being in IBS: Strengths and Happiness (WISH) 2.0

for Irritable Bowel Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06866106·Recruiting

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ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

for Breast Neoplasms

Drug: Pumitamig

26 locations incl. Springdale

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07173751·Phase 3·Recruiting

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Synergistic Gut-brain Axis Modulation Via Vagal Stimulation and Support Therapy in Functional Dyspepsia

for Functional Dyspepsia

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 65

Code: NCT06360900·Recruiting

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Cranberry and Gut Health in Crohn's Disease

for Crohn Disease (CD)

1 location in Worcester

Sponsor: Ana Maldonado-Contreras

Sex: All·Age: 18 - 65

Code: NCT07170462·EARLY_Phase 1·Recruiting

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A Phase 1/2 Study of the Safety and Efficacy of MVX-220 in Angelman Syndrome

for Angelman Syndrome

3 locations incl. Los Angeles

Sponsor: MavriX Bio, LLC

Sex: All·Age: 4 - 50

Code: NCT07181837·Phase 1, Phase 2·Recruiting

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PPDTM CorEvitasTM Obesity (OBR) Drug Effectiveness and Safety Registry

for Obesity

1 location in Waltham

Sponsor: CorEvitas

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07598981·Enrolling By Invitation

Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

for Geographic Atrophy (GA)

27 locations incl. Gilbert

Sponsor: ONL Therapeutics

Sex: All·Age: 55+

Code: NCT06659445·Phase 2·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Bevacizumab

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701656·Phase 2·Recruiting

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OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

for Cardiac Failure

7 locations incl. Los Angeles

Sponsor: Inova Health Care Services

Sex: All·Age: 18 - 99

Code: NCT06939751·Recruiting

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ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With Acromegaly

for Acromegaly

9 locations incl. Los Angeles

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18 - 80

Code: NCT07037420·Phase 2·Recruiting

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Balloon Inflation Time for Esophageal Strictures (BITES): A Randomized Multi-Center Study

for Esophageal Atresia With Tracheo-esophageal Fistula

2 locations incl. Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: Up to 18

Code: NCT07100379·Recruiting

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Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation

for Hypertension

1 location in Boston

Sponsor: Medtronic Vascular

Sex: All·Age: 18+

Code: NCT07174622·Recruiting

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Clinical Trial of OMTX705 in Combination With Gemcitabine/Nab-Paclitaxel and Tislelizumab in Patients With Advanced/Metastatic Pancreatic Adenocarcinoma

for Pancreatic Adenocarcinoma Metastatic

1 location in Boston

Sponsor: Oncomatryx Biopharma S.L.

Sex: All·Age: 18+

Code: NCT07377045·Phase 1·Recruiting

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Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

for Unilateral Vocal Cord Paralysis

10 locations incl. La Jolla

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07579364·Enrolling By Invitation

Extended-release Buprenorphine as a Novel Low-dose Induction Strategy

for Opioid Use Disorder

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06441604·Phase 2·Recruiting

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Study of Oral Fluid Testing Approach

for Cannabis Use

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 18 - 30

Code: NCT06891235·Recruiting

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Microbial Cell-free Metagenomic Sequencing for Suspected Infections in Adult Immunocompromised Outpatients

for Infection

6 locations incl. San Francisco

Sponsor: Karius, Inc.

Sex: All·Age: 18+

Code: NCT07110636·Recruiting

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A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Drug: Divarasib

50 locations incl. Anchorage

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06793215·Phase 3·Recruiting

Apply to this trial