OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

Part of paid clinical trials in Los Angeles, California.

Sponsor
Inova Health Care Services
Study ID
NCT06939751
Status
Recruiting
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Conditions

  • Cardiac Failure
  • Graft Rejection

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

This study aims to develop and refine a microRNA (miR) biomarker panel that can be used to phenotype net immune state after heart transplantation using circulating miRs (associated with drug doses and levels). These miRs will be used to characterize the overall immune state in adult heart transplant patients and predict patients that will go on to develop infection and rejection. MicroRNAs (miRs) are small, non-coding RNA molecules that regulate gene expression and serve as molecular biomarkers found in the circulation.

Key Dates

Start date
Oct 28, 2025
Status verified
Apr 2026
Primary completion
Jan 1, 2031
Completion
Jan 1, 2032

Study Design

Enrollment
250 participants (estimated)

Primary Outcome Measure

Time-to-Event Analysis of Circulating microRNAs (miRs) Predicting Infection in Pediatric Heart Transplant Recipients [ Time Frame: up to 3 years post - transplant ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Cedars-Sinai Medical CenterLos AngelesCalifornia90048
Lucilla Garcia
[email protected]
Jon Kobashigawa, MD (PRINCIPAL_INVESTIGATOR)
Stanford UniversityPalo AltoCalifornia94304
Kiran Khush, MD (PRINCIPAL_INVESTIGATOR)
Tufts Medical CenterBostonMassachusetts02111
Abena Adwetewa-Badu
[email protected]
617-636-9458
Jeong Hwan Kim, MD (PRINCIPAL_INVESTIGATOR)
Medical University of South CarolinaCharlestonSouth Carolina29425
Melissa Amitrano
[email protected]
Ryan Tedford, MD (PRINCIPAL_INVESTIGATOR)
Vanderbilt UniversityNashvilleTennessee37232
Lisa Slinger
[email protected]
Kelly Schlendorf, MD (PRINCIPAL_INVESTIGATOR)
Baylor University Medical CenterDallasTexas75246
Jasha Harvey
[email protected]
Shelley Hall, MD (PRINCIPAL_INVESTIGATOR)
Inova Health SystemFalls ChurchVirginia22042
Michaela Ramandanes, MPH
[email protected]
703-446-6466
Jacqueline Fikry, MSHS
[email protected]
(703) 776-3966

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By research site
Cedars-Sinai Medical Center· Los Angeles, CAStanford University· Palo Alto, CATufts Medical Center· Boston, MAMedical University of South Carolina· Charleston, SCVanderbilt University· Nashville, TNBaylor University Medical Center· Dallas, TX

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