Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs
Part of paid clinical trials in Aurora, Colorado.
- Sponsor
- Inova Health Care Services
- Study ID
- NCT06532890
- Status
- Recruiting
Conditions
- Cardiac Failure
- Graft Rejection
Eligibility Criteria
- Sex
- ALL
- Age
- N/A - 18 Years
- Healthy Volunteers
- Not accepted
Study Details
This study aims to discover circulating microRNAs (associated with drug doses and levels) that can be used to characterize the overall immune state in pediatric heart transplant patients and predict patients that will go on to develop infection and rejection. MicroRNAs (miRs) are small, non-coding RNA molecules that regulate gene expression and serve as molecular biomarkers found in the circulation.
Key Dates
- Start date
- Feb 6, 2025
- Status verified
- Aug 2025
- Primary completion
- Oct 1, 2029
- Completion
- Oct 1, 2029
Study Design
- Enrollment
- 150 participants (estimated)
Primary Outcome Measure
Time-to-Event Analysis of Circulating microRNAs (miRs) Predicting Infection in Pediatric Heart Transplant Recipients [ Time Frame: up to 2 years post-transplant ]
Central Contacts
- Palak Shah, MD(703) 776-8000
- Stephanie Wolak, MPH571-472-8558
Locations (7)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Children's Hospital Colorado | Aurora | Colorado | 80045 | Rebecca Hill Shelley Miyamoto, MD (PRINCIPAL_INVESTIGATOR) |
| University of Michigan | Ann Arbor | Michigan | 48109 | Christine Cislo David Peng, MD (PRINCIPAL_INVESTIGATOR) |
| Columbia University | New York | New York | 10032 | Reina Puri Marc Richmond, MD (PRINCIPAL_INVESTIGATOR) |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15224 | Brian Feingold, MD (PRINCIPAL_INVESTIGATOR) |
| Vanderbilt University | Nashville | Tennessee | 37232 | Darlene Fountain David Bearl, MD (PRINCIPAL_INVESTIGATOR) |
| Texas Children's Hospital | Houston | Texas | 77030 | Blake Fallon Joseph Spinner, MD (PRINCIPAL_INVESTIGATOR) |
| Inova Health System | Falls Church | Virginia | 22042 | - |
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