Clinical Trials at Arkansas Children's Hospital

As of June 2026, 100 paid clinical trials are recruiting at Arkansas Children's Hospital, located at 1 CHILDRENS WAY, SLOT 664, LITTLE ROCK, AR 72202-3500, phone (501) 364-2526 in Little Rock, Arkansas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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100 clinical trials at Arkansas Children's Hospital

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Comparison of Uncomplicated Candidemia Therapy Duration in Children

for Invasive Candidiasis

21 locations incl. Birmingham

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days+

Code: NCT05763251·Recruiting

Apply to this trial

Prevention of Bleeding in Patients With Moderate and Severe Hemophilia A Playing Sports: A Comparison Between Factor VIII and Emicizumab Prophylaxis

for Hemophilia A

9 locations incl. Little Rock

Sponsor: Wayne State University

Sex: All·Age: 6 - 19

Code: NCT05022459·Recruiting

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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

390 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting

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Mitochondrial Energy Metabolism in Burns

for Burn Injury

1 location in Little Rock

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 2 - 80

Code: NCT07643545·Recruiting

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A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

for High Grade Osteosarcoma

Drug: Cabozantinib

175 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 40

Code: NCT05691478·Phase 2, Phase 3·Recruiting

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Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

for Acute Myeloid Leukemia

9 locations incl. Phoenix

Sponsor: Norman J. Lacayo

Sex: All·Age: Up to 21

Code: NCT05101551·Phase 1·Recruiting

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Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

for Ductus Arteriosus, Patent

24 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 7 Days - 32 Days

Code: NCT05547165·Recruiting

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

101 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting

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AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (DMD)

for Duchenne Muscular Dystrophy

13 locations incl. Little Rock

Sponsor: REGENXBIO Inc.

Sex: Male·Age: 1+

Code: NCT05693142·Phase 2, Phase 3·Recruiting

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Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients

for Hematopoietic Cell Transplant

27 locations incl. Birmingham

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: Up to 18

Code: NCT05550298·Recruiting

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Duchenne Electronic Health Record Study

for Duchenne Muscular Dystrophy (DMD)

10 locations incl. Little Rock

Sponsor: The Duchenne Registry

Sex: All·Age: All ages

Code: NCT07609394·Recruiting

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A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

22 locations incl. South Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting

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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

45 locations incl. Phoenix

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting

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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

22 locations incl. Birmingham

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting

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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

for Neuroblastoma

20 locations incl. Birmingham

Sponsor: Giselle Sholler

Sex: All·Age: 12 Months - 21

Code: NCT05489887·Phase 2·Recruiting

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

165 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting

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ASC618 Gene Therapy in Hemophilia A Patients

for Hemophilia A

1 location in Little Rock

Sponsor: ASC Therapeutics

Sex: Male·Age: 18+

Code: NCT04676048·Phase 1, Phase 2·Recruiting

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The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

for Extubation Failure

17 locations incl. Little Rock

Sponsor: University of Pennsylvania

Sex: All·Age: 0 Days - 9 Weeks

Code: NCT05446272·Recruiting

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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

32 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting

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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

for Malignant Glioma

Drug: Selinexor

109 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 Months - 21

Code: NCT05099003·Phase 1, Phase 2·Recruiting

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Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies

for Deep Venous Thrombosis

22 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: Up to 17

Code: NCT04924322·Phase 2, Phase 3·Recruiting

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

164 locations incl. Birmingham

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

219 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting

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Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy

for Cardiomyopathy

21 locations incl. Little Rock

Sponsor: Tenaya Therapeutics

Sex: All·Age: 0 - 18

Code: NCT05112237·Recruiting

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Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)

for Duchenne Muscular Dystrophy

2 locations incl. Little Rock

Sponsor: Wave Life Sciences USA, Inc.

Sex: Male·Age: 4 - 18

Code: NCT04906460·Phase 1, Phase 2·Recruiting

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Safety and Efficacy of Tideglusib in Congenital or Childhood Onset Myotonic Dystrophy

for Congenital Myotonic Dystrophy

10 locations incl. Little Rock

Sponsor: AMO Pharma Limited

Sex: All·Age: 6 - 45

Code: NCT05004129·Phase 2, Phase 3·Recruiting

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A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

149 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting

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CureDuchenne Link®: A Resource for Research

for Duchenne Muscular Dystrophy

10 locations incl. Little Rock

Sponsor: CureDuchenne

Sex: All·Age: 4 Weeks+

Code: NCT04972604·Recruiting

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Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

for Primary Ciliary Dyskinesia

1 location in Little Rock

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 2 - 99

Code: NCT05287022·Recruiting

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Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders

for Langerhan's Cell Histiocytosis

12 locations incl. Phoenix

Sponsor: Carl Allen

Sex: All·Age: All ages

Code: NCT04079179·Phase 2·Recruiting

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DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

for Medulloblastoma

23 locations incl. Little Rock

Sponsor: Giselle Sholler

Sex: All·Age: Up to 21

Code: NCT04696029·Phase 2·Recruiting

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Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

for Recurrent T Acute Lymphoblastic Leukemia

163 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 12+

Code: NCT04315324·Phase 1, Phase 2·Recruiting

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ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

for Acute Respiratory Distress Syndrome

76 locations incl. Birmingham

Sponsor: University of Michigan

Sex: All·Age: 14 Days - 20

Code: NCT05388708·Recruiting

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Beat Childhood Cancer Specimen Banking and Data Registry

for Pediatric Cancer

18 locations incl. Little Rock

Sponsor: Giselle Sholler

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04715178·Recruiting

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A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for Down Syndrome

Drug: Nivolumab

202 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 30

Code: NCT04546399·Phase 2·Recruiting

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A Gene Transfer Therapy Study to Evaluate the Safety of and Expression From Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD)

for Muscular Dystrophy, Duchenne

7 locations incl. Little Rock

Sponsor: Sarepta Therapeutics, Inc.

Sex: Male·Age: 2+

Code: NCT04626674·Phase 1·Recruiting

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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

177 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting

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Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

for Neuroblastoma

25 locations incl. Birmingham

Sponsor: Giselle Sholler

Sex: All·Age: Up to 31

Code: NCT04301843·Phase 2·Recruiting

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A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

for Dravet Syndrome

31 locations incl. Birmingham

Sponsor: Epygenix

Sex: All·Age: 2+

Code: NCT04462770·Phase 3·Recruiting

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A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

185 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting

Apply to this trial