Heart disease Clinical Trials in Kansas City, MO
As of June 2026, 39 paid clinical trials are recruiting for Heart disease in Kansas City, Missouri. Heart disease research tests new drug therapies, device-based interventions, and lifestyle programs for heart failure, atrial fibrillation, hypertension, and coronary disease — including therapies that reduce hospitalization and cardiovascular death. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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39 clinical trials for Heart disease
·Clear filters·↓ Download CSVPivotal Trial to Evaluate the Safety and Effectiveness of the P&F TricValve® Transcatheter Bicaval Valve System
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
Impact of Steerable Delivery Sheaths on Successful Closure of LA A With AMULET
CCM OPEN HF Registry
Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control
Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
Prevail Global Study
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients with Heart Failure Who Are Intolerant or Not Eligible for Treatment with Steroidal Mineralocorticoid Receptor Antagonists
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients with Heart Failure (CONFIRMATION-HF)
Global Paradise System US Post Approval Study
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study
CTSN Embolic Protection Trial
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
The CONFORM Pivotal Trial
Assessment of CCM in HF With Higher Ejection Fraction
Effect of a Quality Improvement Initiative to Address Social Determinants of Health on Rehospitalization Rates in Patients With Heart Failure
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
Product Surveillance Registry
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
About research studies in Kansas City
Kansas City has approximately 488 recruiting research studies across a wide range of therapeutic areas. Missouri hosts Washington University School of Medicine in St. Louis and University of Kansas Medical Center's Missouri partners, known for oncology, genomics, and rare-disease research.
Top Research Study Locations in Kansas City
Researchers run research studies in Kansas City, MO at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Kansas Cancer Center - North | Stage IV Lung Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 54 |
| Children's Mercy Hospital | Bronchopulmonary Dysplasia, Congenital Heart Disease (CHD), Hypertension | 51 |
| Children's Mercy Hospitals and Clinics | Neuroblastoma, Amblyopia, B Acute Lymphoblastic Leukemia | 44 |
| University Health Truman Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8 | 37 |
| University of Kansas Cancer Center - Briarcliff | Stage IV Lung Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Recurrent Lung Non-Small Cell Carcinoma | 35 |
| Saint Luke's Hospital of Kansas City | Heart Failure, Aortic Valve Disease, Breast Cancer | 34 |
| Research Medical Center | Atrial Fibrillation, Stroke, Anatomic Stage II Breast Cancer AJCC v8 | 16 |
| Kansas City Veterans Affairs Medical Center | Chronic Lymphocytic Leukemia, RISS Stage I Plasma Cell Myeloma, RISS Stage II Plasma Cell Myeloma | 13 |
| Saint Luke's Cancer Institute | Breast Cancer, Breast Neoplasms, Metastatic Breast Cancer | 13 |
| Children's Mercy Kansas City | ALL, Childhood, Behavior, Health, Bronchiolitis Acute | 12 |
| Children's Mercy | Acute Brain Injury, Acute Respiratory Distress Syndrome, Angelman Syndrome | 10 |
| Kansas City VA Medical Center, Kansas City, MO | Metastatic Prostate Cancer, Adult Growth Hormone Deficiency, Atherosclerosis | 7 |
| Research Medical Center Clinic | Atrial Fibrillation, Stroke, Aortic Stenosis | 7 |
| St. Luke's Hospital of Kansas City | Amyloid Cardiomyopathy, Amyloidosis, Aortic Stenosis | 7 |
| The Children's Mercy Hospital | Acute Liver Failure, Acute Liver Injury, Alagille Syndrome | 7 |
| Kansas City VA Medical Center | Heart Failure, Atherosclerotic Cardiovascular Disease in Patients With ESKD, Eosinophilic Esophagitis (EoE) | 6 |
| Kansas City Research Institute | Chronic Idiopathic Constipation (CIC), EPP, Liver Fibrosis | 6 |
| Saint Luke's Hospital | HPV-unrelated Head and Neck Squamous Cell Carcinoma, Intra-uterine Device Placement, Mitral Valve Prolapse | 5 |
| University of Kansas Medical Center | Smoking Reduction, Idiopathic Pulmonary Fibrosis (IPF), Severe Sepsis | 5 |
| Clinical Trial Site | Angelman Syndrome, Breast Cancer, ER Positive Breast Cancer | 4 |
| Children's Mercy Research Institute | Anorexia Nervosa, Atypical, Binge Eating, Bulimia Nervosa | 4 |
| MidAmerica Cancer Care | Advanced Melanoma, Large B-cell Lymphoma, Multiple Myeloma | 4 |
| Children's Mercy Adelle Hall Campus | Cerebroside Lipidosis Syndrome, Gaucher Disease, Glucocerebrosidase Deficiency Disease | 4 |
| AMR Clinical | Healthy Adults, Metabolic Dysfunction-Associated Steatotic Liver Disease, Osteoarthritis | 3 |
| AMR Kansas City | Diabetic Peripheral Neuropathic Pain, RSV Infection | 3 |
Active & Upcoming Studies in Kansas City (2026)
Recruiting trials in Kansas City grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (157 active studies)
- Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer · Phase 2 · National Cancer Institute (NCI)
- DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemotherapy · Phase 3 · Boehringer Ingelheim
Cardiovascular (60 active studies)
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction · Phase 3 · Bayer
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
Diabetes & metabolic (23 active studies)
- Addressing Food Access and Physical Activity to Improve Diabetes Prevention Outcomes Among Underserved African Americans · University of Missouri, Kansas City
- Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus · Phase 2 · Hanmi Pharmaceutical Company Limited
Pediatric (21 active studies)
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction · Phase 3 · Bayer
- A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction · Phase 3 · Bayer
Neurology & pain (12 active studies)
- A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With Migraine · Children's Mercy Hospital Kansas City
- Impact of Steerable Delivery Sheaths on Successful Closure of LA A With AMULET · Kansas City Heart Rhythm Research Foundation
Vaccines (6 active studies)
- A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease · Phase 2 · Shionogi
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
HIV / STI (6 active studies)
Eye & vision (6 active studies)
- A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease · Phase 3 · AbbVie
- Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat Glaucoma · Phase 4 · Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,
Mental health & behavior (5 active studies)
- PTSD Screening in Pregnant Black Women · Emory University
- Switching to E-cigarettes in Smokers Not Interested in Quitting · Phase 3 · University of Kansas Medical Center
Common conditions studied in Kansas City
- Heart Failure (18 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Breast Cancer (13 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Malignant Solid Neoplasm (8 active studies). Recruiting Malignant Solid Neoplasm studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Atrial Fibrillation (7 active studies). Atrial fibrillation studies investigate next-generation anticoagulants, ablation technologies, and left atrial appendage closure devices.
- Neuroblastoma (7 active studies). Recruiting Neuroblastoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Acute Myeloid Leukemia (6 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
Leading research sponsors in Kansas City
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Mercy Hospital Kansas City
- Children's Oncology Group
- Merck Sharp & Dohme LLC
Local regulations and guidelines
Clinical trials in Missouri are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Missouri research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Kansas City. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Kansas City
Hipa.ai aggregates every recruiting study in Kansas City from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Kansas City?
There are approximately 488 recruiting clinical trials in Kansas City, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Kansas City pay participants?
Most recruiting trials in Kansas City compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Kansas City?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Kansas City?
The most common conditions under active study in Kansas City include Heart Failure (18), Breast Cancer (13), Malignant Solid Neoplasm (8), Atrial Fibrillation (7), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Kansas City?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Kansas City on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Kansas City?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Kansas City?
Recruiting research sites in Kansas City include University of Kansas Cancer Center - North, Children's Mercy Hospital, Children's Mercy Hospitals and Clinics, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Kansas City right now?
The largest active categories in Kansas City are Cancer & tumors (157), Cardiovascular (60), Diabetes & metabolic (23). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.