Clinical Trials at Mayo Clinic Florida

As of June 2026, 78 paid clinical trials are recruiting at Mayo Clinic Florida, located at 4500 SAN PABLO RD S, JACKSONVILLE, FL 32224-1865, phone (904) 953-2000 in Jacksonville, Florida. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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78 clinical trials at Mayo Clinic Florida

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Bringing Life to Those Near Death

for Palliative Care

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05466123·Enrolling By Invitation

A Study of Intravenous Acetaminophen for Small Bowel Obstruction

for Small Bowel Obstruction

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05878015·Phase 4·Enrolling By Invitation

Cardiac Rehabilitation Mobile-Health Fall Risk Prevention Intervention

for Cardiac Rehabilitation

2 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05826587·Recruiting

Apply to this trial

International Registry of Intra-arterial and Endosaccular Flow Diverters (IRF)

for Intracranial Aneurysm

10 locations incl. Coral Gables

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06174727·Recruiting

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To Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis

for End Stage Renal Disease (ESRD)

32 locations incl. Scottsdale

Sponsor: Humacyte, Inc.

Sex: Female·Age: 18+

Code: NCT05908084·Phase 3·Recruiting

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US National OCS Heart Perfusion (OHP) Registry

for Heart Transplant

37 locations incl. Phoenix

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05915299·Recruiting

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A Study of Renal Microvessel Imaging for Chronic Kidney Disease

for Healthy

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05764642·Phase 2·Enrolling By Invitation

Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics

for Major Depressive Disorder

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 20 - 62

Code: NCT05910957·Enrolling By Invitation

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Drug: Iberdomide

44 locations incl. Aurora

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05827016·Phase 3·Recruiting

Apply to this trial

A Study of Latin Dance for Post- Lung Transplant

for Lung Transplant

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT05924113·Recruiting

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A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

for Focal Onset Seizures

19 locations incl. Little Rock

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05716100·Phase 3·Recruiting

Apply to this trial

An Open-label Study of XEN1101 in Epilepsy

for Focal Epilepsy

53 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05718817·Phase 3·Enrolling By Invitation

A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

for Acute Myeloid Leukemia

8 locations incl. Phoenix

Sponsor: Chordia Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05732103·Phase 1, Phase 2·Recruiting

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Prospective Carotid Artery Stenosis Trial

for Patients With Any Degree of Carotid Artery Stenosis and Vulnerable Features in the Carotid Artery Plaque

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05724836·Recruiting

Apply to this trial

Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression

for Periprosthetic Joint Infection

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05640336·Enrolling By Invitation

A Study of Physiologic Changes in a Telemetry Unit

for Acute Illness Requiring to Hospital Telemetry Admission

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT05534516·Enrolling By Invitation

(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer

for Breast Neoplasms

15 locations incl. Phoenix

Sponsor: Atossa Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT05607004·Phase 2·Recruiting

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A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

for Primary Generalized Tonic-Clonic Seizures

59 locations incl. Mobile

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05667142·Phase 3·Recruiting

Apply to this trial

Pilot/Pivotal Study of DBS+Rehab After Stroke

for Stroke

10 locations incl. Phoenix

Sponsor: Enspire DBS Therapy, Inc.

Sex: All·Age: 21+

Code: NCT05701280·Recruiting

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Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

for Castrate Resistant Prostate Cancer

6 locations incl. Phoenix

Sponsor: Epigenetix, Inc.

Sex: All·Age: 18+

Code: NCT05488548·Phase 1·Recruiting

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Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

for Advanced Melanoma

Drug: Tebentafusp

25 locations incl. Phoenix

Sponsor: Immunocore Ltd

Sex: All·Age: 18+

Code: NCT05549297·Phase 3·Recruiting

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Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

for Triple Negative Breast Cancer

184 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05633654·Phase 3·Recruiting

Apply to this trial

PAIN (Pain AI iNtervention) Platform for Patients at Home

for Pain

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05474274·Enrolling By Invitation

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

for Idiopathic Pulmonary Fibrosis

86 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 40+

Code: NCT04905693·Phase 3·Enrolling By Invitation

Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome

for Obese

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05408728·Enrolling By Invitation

Research for Individualized Therapeutics in Rare Genetic Disease

for Rare Genetic Disease

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05236595·Enrolling By Invitation

Retina is a Marker for Cerebrovascular Heath

for Cerebral Small Vessel Diseases

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04753970·Phase 1, Phase 2·Recruiting

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HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

25 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting

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Radial Vs. State-Of-The-Art Femoral Access for Bleeding and Access Site Complication Reduction in Cardiac Catheterization (REBIRTH)

for Patient Satisfaction

6 locations incl. San Francisco

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: 18+

Code: NCT04077762·Recruiting

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Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

for Congenital Disorders of Glycosylation

12 locations incl. San Diego

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: All ages

Code: NCT04199000·Recruiting

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Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)

for Cardiopulmonary

15 locations incl. Scottsdale

Sponsor: Prolaio

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05678530·Recruiting

Apply to this trial

Intravital Microscopy in Human Solid Tumors

for Solid Tumor, Adult

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT03823144·Recruiting

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Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

for Previously Untreated Relapsed Refractory Acute Myeloid Leukemia

19 locations incl. Phoenix

Sponsor: Beat AML, LLC

Sex: All·Age: 18+

Code: NCT03013998·Phase 1, Phase 2·Recruiting

Apply to this trial

Senescence in Chronic Kidney Disease

for Chronic Kidney Disease

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 40 - 80

Code: NCT02848131·Phase 2·Enrolling By Invitation

Pulmonary Hypertension Association Registry

for Pulmonary Arterial Hypertension

52 locations incl. Phoenix

Sponsor: Pulmonary Hypertension Association, Inc.

Sex: All·Age: 0+

Code: NCT04071327·Recruiting

Apply to this trial

Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques

for Abdominal Aortic Aneurysm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT02548546·Recruiting

Apply to this trial

Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders

for Amyotrophic Lateral Sclerosis

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05474235·Recruiting

Apply to this trial