Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders

Part of paid clinical trials in Jacksonville, Florida.

Sponsor
Mayo Clinic
Study ID
NCT05474235
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

The purpose of this study is to collect, from patients with sporadic and familial ALS and their family members, clinical data and blood samples for extraction of DNA, RNA, preparation of lymphocytes, plasma and serum to establish a repository for future investigations of genetic contributions to ALS pathogenesis. Blood samples for DNA extraction also would be collected from control subjects with no personal or family history of ALS phenotypes.

Key Dates

Start date
Dec 31, 2007
Status verified
Aug 2025
Primary completion
Dec 31, 2038
Completion
Dec 31, 2038

Study Design

Enrollment
3,000 participants (estimated)

Arms

  • Arm: ALS or Suspected ALS Patient
    Subjects with clinical diagnosis of possible, laboratory-supported probable, probable or definite, ALS or diagnosis of a neurodegenerative disorder with evidence of ALS plus extramotor features or a blood relative (first, second or third degree) with history of ALS or neurodegenerative disorder with evidence of ALS plus extramotor features.
  • Arm: Blood Relative of ALS Patient
    Subjects with family history (first, second or third degree blood relative) of ALS or other motor neuron disease.
  • Arm: Healthy Control
    Subjects with no personal or family history (first, second or third degree blood relative) of ALS or other motor neuron disease

Primary Outcome Measure

Blood Collection [ Time Frame: 50 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic FloridaJacksonvilleFlorida32224
Chris Liriano
[email protected]
904-953-5325

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Mayo Clinic Florida· Jacksonville, FL

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