Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome

Part of paid clinical trials in Jacksonville, Florida.

Sponsor
Mayo Clinic
Study ID
NCT05408728
Status
Enrolling By Invitation

Conditions

  • Bariatric Surgery Candidate
  • Healthy
  • Obese

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Endoscopic biopsy — PROCEDURE
    Upper small intestinal biopsies from patients undergoing BS will be collected during routine standard of care screening EGD and again from the same patients at 1 year during routine standard of care surveillance EGD (esophageal reflux screening/surveillance). Biopsy-derived enteroid cultures and tissue samples from pre- and one-year post BS will be examined for expression level of sugar transporters and gluconeogenic enzymes; glucose and fructose absorption

Study Details

This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.

Key Dates

Start date
Jul 10, 2022
Status verified
Sep 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
52 participants (estimated)

Arms

  • Arm: Obese patients scheduled for Bariatric surgery
    Subjects scheduled for Bariatric Surgery (BS) and will receive pre-BS Esophagogastroduodenoscopy (EGD) as a part of your standard care will have biopsies from the small intestine taken during the EGD procedure for this study.
  • Arm: Lean controls naive to Bariatric surgery
    Subjects presenting for surveillance/screening EGD procedure as part of their standard medical care will have biopsies from the small intestine taken during the EGD procedure for this study.

Primary Outcome Measure

Number of obese patients with altered dietary sugar hyper-absorptive phenotype after bariatric surgery [ Time Frame: 18 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic FloridaJacksonvilleFlorida32224-

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By research site
Mayo Clinic Florida· Jacksonville, FL

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