Clinical Trials at University of Iowa

As of June 2026, 210 paid clinical trials are recruiting at University of Iowa, located at 200 HAWKINS DR, IOWA CITY, IA 52242, phone (319) 356-1616 in Iowa City, Iowa. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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210 clinical trials at University of Iowa

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Post-Market Clinical Investigation of the IotaSOFT Insertion System

for Hearing Loss, Cochlear

3 locations incl. Indianapolis

Sponsor: iotaMotion, Inc.

Sex: All·Age: 12+

Code: NCT06664697·Recruiting

Apply to this trial

Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes

for Gestational Diabetes

1 location in Iowa City

Sponsor: Anna Stanhewicz, PhD

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05917587·EARLY_Phase 1·Recruiting

Apply to this trial

A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

for Non-cystic Fibrosis Bronchiectasis

29 locations incl. Birmingham

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 18 - 80

Code: NCT06559150·Phase 2·Recruiting

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Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter

for Acute Ischemic Stroke From Large Vessel Occlusion

11 locations incl. Jacksonville

Sponsor: Anaconda Biomed S.L.

Sex: All·Age: 22 - 85

Code: NCT06370182·Recruiting

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A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

for Lupus Erythematosus, Systemic

19 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06581198·Phase 2·Recruiting

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The Effects of Heel Distraction Height on Foot Loading With Carbon Fiber Custom Dynamic Orthoses

for Traumatic Lower Limb Injury

1 location in Iowa City

Sponsor: University of Iowa

Sex: All·Age: 18 - 65

Code: NCT06127316·Recruiting

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Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

for Electronic Cigarette Use

2 locations incl. Iowa City

Sponsor: University of Iowa

Sex: All·Age: 18 - 24·Accepts healthy volunteers

Code: NCT06489249·EARLY_Phase 1·Recruiting

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Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

7 locations incl. Gilbert

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT06544798·Phase 2·Enrolling By Invitation

Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation

for Endothelial Function

1 location in Iowa City

Sponsor: University of Iowa

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06499844·EARLY_Phase 1·Recruiting

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Real-time Personalized Brain State-dependent TMS After Stroke

for Stroke

1 location in Iowa City

Sponsor: Sara Hussain

Sex: All·Age: 18+

Code: NCT06533176·Recruiting

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A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J

for Peripheral Neuropathy

3 locations incl. San Francisco

Sponsor: Elpida Therapeutics SPC

Sex: All·Age: All ages

Code: NCT06151600·Recruiting

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VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for Advanced Melanoma

Drug: Nivolumab

50 locations incl. Gilbert

Sponsor: Replimune, Inc.

Sex: All·Age: 12+

Code: NCT06264180·Phase 3·Recruiting

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From Opinion to Evidence: Multi-site Evaluation of Custom Dynamic Orthosis Best Practices

for Foot Injury

5 locations incl. San Diego

Sponsor: Jason Wilken

Sex: All·Age: 18 - 65

Code: NCT06352788·Recruiting

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Dime La VerDAD: Verify, Debunk, and Disseminate

for Influenza

4 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06417762·Recruiting

Apply to this trial

Parasitic Ulcer Treatment Trial

for Acanthamoeba Keratitis

13 locations incl. San Francisco

Sponsor: Jeremy Keenan, MD, MPH

Sex: All·Age: 8+

Code: NCT06213649·Phase 3·Recruiting

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

73 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting

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A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections

for Neutropenia

22 locations incl. Phoenix

Sponsor: X4 Pharmaceuticals

Sex: All·Age: 12+

Code: NCT06056297·Phase 3·Recruiting

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A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

for Pediatric

Drug: Aficamten

26 locations incl. Phoenix

Sponsor: Cytokinetics

Sex: All·Age: 12 - 17

Code: NCT06412666·Phase 2, Phase 3·Recruiting

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Multi-Center Clean Air Randomized Controlled Trial in COPD

for Chronic Obstructive Pulmonary Disease (COPD)

11 locations incl. Birmingham

Sponsor: JHSPH Center for Clinical Trials

Sex: All·Age: 40+

Code: NCT06376994·Phase 3·Recruiting

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Neuronal and Network Mechanisms of Electrocortical Stimulation

for Epilepsy

3 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT06391294·Enrolling By Invitation

Treatment Targets in Spanish and English Bilingual Speech Intervention

for Speech Sound Disorder

1 location in Iowa City

Sponsor: Philip Combiths

Sex: All·Age: 3 - 8

Code: NCT06416306·Phase 1·Recruiting

Apply to this trial

Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer

for Prostate Cancer

44 locations incl. Homewood

Sponsor: Curium US LLC

Sex: Male·Age: 18+

Code: NCT06235151·Phase 3·Recruiting

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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

41 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06297226·Phase 2·Recruiting

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Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

for Cutaneous Melanoma

Drug: Avutometinib

2 locations incl. Iowa City

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT06194929·Phase 1, Phase 2·Recruiting

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VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study

for Crohn's Disease

12 locations incl. Sun City

Sponsor: Alimentiv Inc.

Sex: All·Age: 18+

Code: NCT06249555·Recruiting

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Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19

for Long COVID

3 locations incl. Iowa City

Sponsor: MaxWell Clinic, PLC

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06311435·Recruiting

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OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome

for Hyperphagia in Prader-Willi Syndrome

19 locations incl. Birmingham

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 5 - 30

Code: NCT06420297·Phase 3·Enrolling By Invitation

Reliability of Force Measurement Within the Carbon Fiber Orthosis Proximal Cuff

for Healthy

1 location in Iowa City

Sponsor: University of Iowa

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT06127264·Recruiting

Apply to this trial

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

34 locations incl. Little Rock

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting

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An Open-Label Study of CTI-1601 in Subjects With Friedreich's Ataxia

for Friedreich Ataxia

8 locations incl. Los Angeles

Sponsor: Larimar Therapeutics, Inc.

Sex: All·Age: 2 - 60

Code: NCT06447025·Phase 2·Recruiting

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Evaluation of the Automated Integration of a Robotics and ECochG System for Use With Cochlear Implant Surgery

for Hearing Loss, Sensorineural

1 location in Iowa City

Sponsor: iotaMotion, Inc.

Sex: All·Age: 12+

Code: NCT06664710·Recruiting

Apply to this trial

Complex Aneurysm Registry - Real-World Evidence Data Collection Intracranial Aneurysm Treatment Devices

for Aneurysm Cerebral

5 locations incl. Hollywood

Sponsor: Microvention-Terumo, Inc.

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06215105·Enrolling By Invitation

Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

for Delirium

1 location in Iowa City

Sponsor: University of Iowa

Sex: All·Age: 65+

Code: NCT05461092·EARLY_Phase 1·Recruiting

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Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

for Prostate Cancer Metastatic

44 locations incl. Orange

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: All ages

Code: NCT06136624·Phase 3·Recruiting

Apply to this trial

Sex Differences in the Vascular Effects of E-cigarette Use

for E-cigarette Use

1 location in Iowa City

Sponsor: Anna Stanhewicz, PhD

Sex: All·Age: 18 - 24·Accepts healthy volunteers

Code: NCT06159608·EARLY_Phase 1·Recruiting

Apply to this trial

Hyperpolarized 129Xe MRI Lung Health Cohort

for Healthy

6 locations incl. Chicago

Sponsor: University of Kansas Medical Center

Sex: All·Age: 25 - 35

Code: NCT05766384·Recruiting

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Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)

for Soft Tissue Sarcoma

26 locations incl. Phoenix

Sponsor: Polaris Group

Sex: All·Age: 18 - 99

Code: NCT05712694·Phase 3·Recruiting

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Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy

for Becker Muscular Dystrophy

24 locations incl. Little Rock

Sponsor: Edgewise Therapeutics, Inc.

Sex: Male·Age: All ages

Code: NCT06066580·Phase 2·Enrolling By Invitation

Daily Aspirin Treatment After Preeclampsia

for Preeclampsia

1 location in Iowa City

Sponsor: Anna Stanhewicz, PhD

Sex: Female·Age: 18 - 50

Code: NCT06168461·EARLY_Phase 1·Recruiting

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A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction

for Lung Transplant Rejection

32 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06082037·Phase 3·Recruiting

Apply to this trial