Real-time Personalized Brain State-dependent TMS After Stroke

Part of paid clinical trials in Iowa City, Iowa.

Sponsor
Sara Hussain
Study ID
NCT06533176
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Personalized brain state-dependent single-pulse TMS — DEVICE
    Single-pulse TMS will be applied to the lesioned hemisphere during brain activity patterns associated with strong residual corticospinal tract activation and random brain activity patterns.

Study Details

Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and upper extremity motor impairment.

Key Dates

Start date
Aug 1, 2024
Status verified
Jan 2026
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
37 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Brain state-dependent TMS during strong states
  • Active Comparator: Brain state-dependent TMS during random states

Primary Outcome Measure

MEP amplitudes [ Time Frame: 1 week ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of IowaIowa CityIowa52242
Sara Hussain
[email protected]
847-309-5189

Find similar trials in Iowa City, IA

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
University of Iowa· Iowa City, IA

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