Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

for Acute Myeloid Leukemia

Drug: Venetoclax

9 locations incl. New Haven

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06419634·Phase 1·Recruiting

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Prenatal Sonographic Prediction of Placental Histology and Function

for Pregnancy Complications

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06022458·Recruiting

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A Study of Pitolisant in Patients With Prader-Willi Syndrome

for Prader-Willi Syndrome

21 locations incl. Los Angeles

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 6+

Code: NCT06366464·Phase 3·Recruiting

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Fasting Mimicking Diet (FMD) in Conjunction With Chemotherapy in Advanced Ovarian Cancer

for Ovarian Cancer

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 18+

Code: NCT05921149·Not Yet Recruiting

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

for Non-small Cell Lung Cancer

Drug: Calderasib

15 locations incl. Bakersfield

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06345729·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

for Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis

135 locations incl. Birmingham

Sponsor: 89bio, Inc.

Sex: All·Age: 18 - 75

Code: NCT06419374·Phase 3·Recruiting

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WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

for Glioblastoma, IDH-Wildtype

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05879250·Phase 2·Recruiting

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Advancing Transplantation Outcomes in Children

for Kidney Transplant

20 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 13 - 20

Code: NCT06055608·Phase 2·Recruiting

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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

for Hiv

13 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06263426·Recruiting

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Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

22 locations incl. Birmingham

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06343402·Phase 1·Recruiting

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Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

for Systemic Lupus Erythematosus

Drug: Ianalumab

21 locations incl. Anniston

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT06133972·Phase 3·Recruiting

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A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

30 locations incl. Springdale

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06203210·Phase 3·Recruiting

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A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias

for Acute Myeloid Leukemias

26 locations incl. Burbank

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06226571·Phase 1·Recruiting

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Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 location in Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 22 - 65

Code: NCT05647044·Phase 1·Recruiting

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Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Drug: Polatuzumab Vedotin

8 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06015880·Phase 1·Recruiting

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A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors

for Breast Neoplasms

82 locations incl. Tucson

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT06157892·Phase 2·Recruiting

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VE303 for Prevention of Recurrent Clostridioides Difficile Infection

for Clostridium Difficile

84 locations incl. Huntsville

Sponsor: Vedanta Biosciences, Inc.

Sex: All·Age: 12+

Code: NCT06237452·Phase 3·Recruiting

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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

for Asthma

105 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 12 - 17

Code: NCT06307665·Phase 3·Recruiting

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Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Etentamig

46 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06158841·Phase 3·Recruiting

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Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection

for Infectious Disease

1 location in Chicago

Sponsor: Mount Sinai Hospital, Canada

Sex: All·Age: 60+

Code: NCT06004739·Recruiting

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Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma

for Urothelial Carcinoma

4 locations incl. Gainesville

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 19+

Code: NCT06262516·Recruiting

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Neuronal and Network Mechanisms of Electrocortical Stimulation

for Epilepsy

3 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT06391294·Enrolling By Invitation

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

for Cerebral Amyloid Angiopathy

34 locations incl. Los Angeles

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 30+

Code: NCT06393712·Phase 2·Recruiting

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A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

for Neuroendocrine Tumors

4 locations incl. Atlanta

Sponsor: Chimeric Therapeutics

Sex: All·Age: 18 - 85

Code: NCT06055439·Phase 1, Phase 2·Recruiting

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A Registry for People With Lung Cancer

for Lung Cancer

15 locations incl. Tucson

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06424327·Recruiting

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Posterior Rectus Sheath Hiatal Augmentation in Paraesophageal Hernia Repair

for Paraesophageal Hernia

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06551077·Recruiting

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A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome

for Dravet Syndrome

10 locations incl. San Francisco

Sponsor: Encoded Therapeutics

Sex: All·Age: 6 Months - 17

Code: NCT05419492·Phase 1, Phase 2·Recruiting

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Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

for Bipolar Depression

52 locations incl. Dothan

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 10 - 17

Code: NCT06372964·Phase 3·Recruiting

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A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

for Advanced or Metastatic Solid Tumors

14 locations incl. Phoenix

Sponsor: 858 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06395519·Phase 1, Phase 2·Recruiting

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A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII Deficiency)

for Healthy Participants

9 locations incl. Glendale

Sponsor: Equilibra Bioscience LLC

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06349473·Phase 1·Recruiting

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Beyond MARS: Magnetic Resonance Study: A Novel Assessment of Placental Perfusion During Pregnancy

for Pregnancy

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 18 - 60

Code: NCT06314009·Recruiting

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Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

for Acute Ischemic Stroke

51 locations incl. Mobile

Sponsor: Mercy Health Ohio

Sex: All·Age: 18 - 79

Code: NCT05611242·Phase 3·Recruiting

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Long Term Follow-up for RGX-202

for Duchenne Muscular Dystrophy

5 locations incl. Little Rock

Sponsor: REGENXBIO Inc.

Sex: Male·Age: All ages

Code: NCT06491927·Enrolling By Invitation

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

for Malignant Female Reproductive System Neoplasm

186 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06126276·Phase 2·Recruiting

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Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

for AAA - Abdominal Aortic Aneurysm

56 locations incl. Little Rock

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06218875·Recruiting

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Breaking Sitting with High-intensity Interval Training for Brain Health

for Aging

1 location in Urbana

Sponsor: University of Illinois at Urbana-Champaign

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT06243016·Recruiting

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A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

for Duchenne Muscular Dystrophy

12 locations incl. Little Rock

Sponsor: Solid Biosciences Inc.

Sex: Male·Age: 0 - 17

Code: NCT06138639·Phase 1, Phase 2·Recruiting

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A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

for Idiopathic Pulmonary Fibrosis

Drug: Nerandomilast

58 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06238622·Phase 3·Recruiting

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Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes

for Type 2 Diabetes Mellitus

38 locations incl. Birmingham

Sponsor: Endogenex, Inc.

Sex: All·Age: 22 - 70

Code: NCT06267391·Recruiting

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Noninvasive Brain Stimulation in Adult Amblyopia

for Amblyopia

1 location in Downers Grove

Sponsor: Midwestern University

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06712849·Recruiting

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