Beyond MARS: Magnetic Resonance Study: A Novel Assessment of Placental Perfusion During Pregnancy

Part of paid clinical trials in Evanston, Illinois.

Sponsor
Endeavor Health
Study ID
NCT06314009
Status
Recruiting
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Conditions

  • Pregnancy

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • functional Magnetic Resonance Imaging (fMRI) — DIAGNOSTIC_TEST
    Participants will undergo a functional Magnetic Resonance Imaging (fMRI) using arterial spin labeling (ASL) and other Magnetic Resonance (MR) sequences

Study Details

The purpose of this study is to evaluate the flow of oxygen and blood necessary for nutrient transfer across the placenta during the second and third trimesters in pregnancy in women who are obese before pregnancy compared to women who have an average weight before pregnancy. This study will evaluate blood flow across the placenta by functional Magnetic Resonance Imaging (fMRI). The investigators hypothesize that there will be differences in placental oxygenation and blood flow among women with obesity as compared to those with normal weight. Participants will be asked to complete: * MRI in the second trimester (20-24 weeks) * MRI in the third trimester (30-34 weeks)

Key Dates

Start date
May 9, 2024
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: Normal Weight
    Body Mass Index (BMI) 18.5-24.9 kg/m\^2
  • Arm: Obese
    Pre-pregnancy Body Mass Index (BMI) ≥ 30.0 kg/m\^2

Primary Outcome Measure

Inter - rater reliability of assessing placental blood flow by arterial spin labeling (ASL) [ Time Frame: 6 weeks after the delivery ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Endeavor HealthEvanstonIllinois60201
Caitlin MacGregor, MD
[email protected]

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By research site
Endeavor Health· Evanston, IL

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