Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

Part of paid clinical trials in Birmingham, Alabama.

Sponsor: Johns Hopkins University
Study ID: NCT06263426
Status: Recruiting

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Conditions

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

HIV D+/R+ — OTHER
Receipt of kidney transplant from a deceased donor with HIV.
HIV D-/R+ — OTHER
Receipt of kidney transplant from a deceased donor without HIV.

Study Details

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

Key Dates

Start date: May 22, 2024
Status verified: Jun 2026
Primary completion: Sep 30, 2028
Completion: Sep 30, 2029

Study Design

Enrollment: 200 participants (estimated)
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Arms

Experimental: HIV D+/R+
People living with HIV who receive kidneys from deceased donors with HIV
Experimental: HIV D-/R+
People living with HIV who receive kidneys from deceased donors without HIV

Primary Outcome Measure

Cumulative incidence of death and allograft rejection. [ Time Frame: From date of transplant to end of year 1 ]

Central Contacts

Christine Durand, MD
410-614-6702
[email protected]

Locations (13)

Facility	City	State	ZIP	Site coordinators
University of Alabama at Birmingham	Birmingham	Alabama	35294	Shikha Mehta, MD [email protected] Shikha Mehta, MD (PRINCIPAL_INVESTIGATOR)
University of California, Los Angeles	Los Angeles	California	90095	Joanna Schaenman, MD, PhD [email protected] Joanna Schaenman, MD, PhD (PRINCIPAL_INVESTIGATOR)
University of California, San Diego	San Diego	California	92037	Saima Aslam, MBBS [email protected] Saima Aslam, MBBS (PRINCIPAL_INVESTIGATOR)
University of California, San Francisco	San Francisco	California	94143	Garrett Roll, MD [email protected] Garrett Roll, MD (PRINCIPAL_INVESTIGATOR)
Rush University Medical Center	Chicago	Illinois	60612	Carlos Santos, MD [email protected] Carlos Santos, MD (PRINCIPAL_INVESTIGATOR)
Ochsner Clinic Foundation	New Orleans	Louisiana	70121	Jonathan Hand, MD [email protected] Jonathan Hand, MD (PRINCIPAL_INVESTIGATOR)
Johns Hopkins University	Baltimore	Maryland	21205	Christine Durand, MD [email protected] Christine Durand, MD (PRINCIPAL_INVESTIGATOR)
Massachusetts General Hospital	Boston	Massachusetts	02114	Nahel Elias, MD [email protected] Nahel Elias, MD (PRINCIPAL_INVESTIGATOR)
Columbia University	New York	New York	10032	Marcus Pereira, MD Marcus Pereira, MD (PRINCIPAL_INVESTIGATOR)
Icahn School of Medicine at Mt. Sinai	New York	New York	10029	Sander Florman, MD [email protected] Sander Florman, MD (PRINCIPAL_INVESTIGATOR)
New York University	New York	New York	10016	Sapna Mehta, MD [email protected] Sapna Mehta, MD (PRINCIPAL_INVESTIGATOR)
Weill Cornell Medical Center	New York	New York	10065	Catherine Small, MD [email protected] Catherine Small, MD (PRINCIPAL_INVESTIGATOR)
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15213	Ghady Haidar, MD [email protected] Ghady Haidar, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Birmingham, AL

By condition

HIV

By specialty

Infectious disease

By research site

University of Alabama at Birmingham· Birmingham, AL University of California, Los Angeles· Los Angeles, CA University of California, San Diego· San Diego, CA University of California, San Francisco· San Francisco, CA Rush University Medical Center· Chicago, IL Ochsner Clinic Foundation· New Orleans, LA

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