Breaking Sitting with High-intensity Interval Training for Brain Health

Part of paid clinical trials in Urbana, Illinois.

Sponsor
University of Illinois at Urbana-Champaign
Study ID
NCT06243016
Status
Recruiting
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Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
40 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • High-Intensity Interval Training (HIIT) Breaks to Sitting — BEHAVIORAL
    HIIT Breaks: a 3.5-hour sitting will be interrupted every 30 min with 6-min HIIT Breaks. During sitting participants will engage in standardized sedentary activities. Each 6-min HIIT break comprises a one-minute warm-up, followed by a 2-minute high-intensity interval, one minute rest (sitting on a cycle ergometer) followed by another 2 minutes at high intensity.
  • Light-Intensity Interval Training (LIIT) Breaks to Sitting — BEHAVIORAL
    LIIT Breaks: a 3.5-hour sitting will be interrupted every 30 min with 6-min LIIT Breaks. Each 6-min LIIT break comprises a one-minute warm-up, followed by a 2-minute light-intensity interval, one minute rest (sitting on a cycle ergometer) followed by another 2-minute light-intensity interval.

Study Details

This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT breaks to sitting. It will also address several important but unanswered questions: (1) Does interrupting sitting with short HIIT breaks improve frontoparietal function? (2) Can interrupting sitting with HIIT breaks improve cognitive functions?

Key Dates

Start date
May 7, 2024
Status verified
Feb 2025
Primary completion
Jul 31, 2025
Completion
Jul 31, 2025

Study Design

Enrollment
54 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Active Comparator: High-Intensity Interval Training (HIIT) Breaks
    Sitting interrupted every 30 min by 6-min HIIT bouts.
  • Sham Comparator: Light-Intensity Interval Training (HIIT) Breaks
    Sitting interrupted every 30 min by 6-min LIIT bouts.

Primary Outcome Measure

Change in task-evoked brain activity [ Time Frame: Immediately before intervention, 2 x during the intervention (50 min and 120 min into the intervention), and immediately after the intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Illinois at Urbana-ChampaignUrbanaIllinois61801
Dominika M Pindus, PhD
[email protected]
2173007317

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By research site
University of Illinois at Urbana-Champaign· Urbana, IL

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