Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)

for Acute Leukemia

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06207123·Phase 1, Phase 2·Recruiting

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Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial

for Prostate Adenocarcinoma

5 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT06022822·Phase 2·Recruiting

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Expanding Liver Transplant Immunosuppression Minimization Via Everolimus

for Liver Transplant

8 locations incl. Phoenix

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06280950·Phase 2·Recruiting

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Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

8 locations incl. Naples

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 18+

Code: NCT05839730·Recruiting

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Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for Metastatic Dedifferentiated Liposarcoma

245 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06422806·Phase 3·Recruiting

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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The TRICURE EFS Study

for Tricuspid Valve Regurgitation

8 locations incl. Atlanta

Sponsor: TRiCares

Sex: All·Age: 18+

Code: NCT06506942·Recruiting

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A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products

for ACL Reconstruction

1 location in Westmont

Sponsor: Illinois Center for Orthopaedic Research and Education

Sex: All·Age: 16 - 65

Code: NCT06979804·Recruiting

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A Novel Intervention for Weight Loss in Young Adults

for Weight Loss

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06230744·Recruiting

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PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.

for Androgen Axis Suppression

Drug: Apalutamide

5 locations incl. Chicago

Sponsor: M.D. Anderson Cancer Center

Sex: Male·Age: 18+

Code: NCT06274047·Phase 3·Recruiting

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Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

for Migraine

Drug: Ubrogepant

103 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06417775·Phase 3·Recruiting

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Impact of Artificial Intelligence on Trainee Polyp Miss Rates

for Colon Polyps

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06676930·Recruiting

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A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

for Melanoma

104 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06246916·Phase 3·Recruiting

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Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter

for Acute Ischemic Stroke From Large Vessel Occlusion

11 locations incl. Jacksonville

Sponsor: Anaconda Biomed S.L.

Sex: All·Age: 22 - 85

Code: NCT06370182·Recruiting

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Time-restricted Eating Among Pregnant Females With Severe Obesity

for Obesity, Morbid

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18 - 44·Accepts healthy volunteers

Code: NCT06477120·Recruiting

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Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures

for Post Procedural Erythema

31 locations incl. Birmingham

Sponsor: Acorn Biolabs Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477172·Recruiting

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Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population

for Enhanced Recovery After Surgery in a Pediatric Population

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 3 - 12·Accepts healthy volunteers

Code: NCT06538584·Phase 1, Phase 2·Recruiting

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Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation

for Traumatic Brain Injury

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 65

Code: NCT06589362·Recruiting

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Relugolix and Enzalutamide in Combination With Radiation Therapy for the Treatment of Very High Risk Prostate Cancer, OPTIMAL Trial

for Prostate Adenocarcinoma

Drug: Relugolix

1 location in Chicago

Sponsor: Sean Sachdev

Sex: Male·Age: 18+

Code: NCT06499870·Phase 2·Recruiting

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EAT: A Reliable Eating Assessment Technology for Free-living Individuals

for Wearable Electronic Device

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06118528·Recruiting

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Intensive Patient Referral and Education Program Prior to Renal Replacement Therapy

for Chronic Kidney Disease

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT06397456·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

for NASH - Nonalcoholic Steatohepatitis

Drug: Efruxifermin

168 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06528314·Phase 3·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

for Lupus Erythematosus, Systemic

19 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06581198·Phase 2·Recruiting

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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

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First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

for Solid Tumor, Adult

9 locations incl. Los Angeles

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT06554795·Phase 1, Phase 2·Recruiting

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Primary Subtalar Arthrodesis for Calcaneal Fractures

for Calcaneus Fracture

17 locations incl. Orange

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06249126·Recruiting

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IMARA for Black Male Caregivers and Girls Empowerment (IMAGE)

for Sexually Transmitted Infections (Not HIV or Hepatitis)

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 13+·Accepts healthy volunteers

Code: NCT06266416·Recruiting

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Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

for Huntington Disease

13 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 60

Code: NCT06667414·Recruiting

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Rural Illinois Lung Cancer Screening Initiative

for Lung Cancer

1 location in Springfield

Sponsor: Southern Illinois University

Sex: All·Age: 50 - 80

Code: NCT06084078·Recruiting

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Activity and Recreation in Communities for Health

for Depression

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06093282·Enrolling By Invitation

Massed Prolonged Exposure for PTSD in Substance Use Treatment

for Stress Disorders, Post-Traumatic

4 locations incl. San Diego

Sponsor: Veterans Medical Research Foundation

Sex: All·Age: 18+

Code: NCT06296186·Recruiting

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CCHS Secure Health-hub Advancing Research Efforts (CCHS SHARE)

for Congenital Central Hypoventilation Syndrome

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: All ages

Code: NCT06554275·Recruiting

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Evolution of the Chicago Classification: Bridging Physiology and Mechanics

for Dysphagia

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT06883175·Recruiting

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CRS Questionnaire Validation Project

for Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

5 locations incl. Santa Monica

Sponsor: The European Forum for Research and Education in Allergy and Airway Diseases

Sex: All·Age: 18+

Code: NCT06970977·Recruiting

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A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients With Antibody-Mediated Rejection (AMR)

for Antibody-mediated Rejection

Drug: Efgartigimod PH20 SC

8 locations incl. Birmingham

Sponsor: argenx

Sex: All·Age: 18 - 80

Code: NCT06503731·Phase 2·Recruiting

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EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

for Kidney Disease, Chronic

Drug: Empagliflozin

41 locations incl. Huntsville

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06531824·Phase 3·Recruiting

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LMN-201 for Prevention of C. Difficile Infection Recurrence

for Clostridioides Difficile Infection

16 locations incl. Escondido

Sponsor: Lumen Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT05330182·Phase 2, Phase 3·Recruiting

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A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

for Advanced Non-small Cell Lung Cancer, HER2 Mutation

27 locations incl. Newport Beach

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06452277·Phase 3·Recruiting

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Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence

for Stress Urinary Incontinence

7 locations incl. La Jolla

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 21+

Code: NCT06480227·Recruiting

Apply to this trial