Massed Prolonged Exposure for PTSD in Substance Use Treatment

Part of paid clinical trials in San Diego, California.

Sponsor
Veterans Medical Research Foundation
Study ID
NCT06296186
Status
Recruiting
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Conditions

  • Stress Disorders, Post-Traumatic
  • Substance Use Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Prolonged Exposure Therapy — BEHAVIORAL
    Exposure therapy for PTSD

Study Details

The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are: * Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms? * Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.

Key Dates

Start date
Sep 1, 2024
Status verified
Apr 2025
Primary completion
Jul 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Massed PE
    Prolonged Exposure delivered in a massed format - sessions multiple times per week
  • Active Comparator: Weekly PE
    Prolonged Exposure delivered with weekly sessions

Primary Outcome Measure

Clinician Administered PTSD Scale for DSM-5 (CAPS-5) [ Time Frame: At 4-, 16-, 28-, and 40-weeks post-first therapy session ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
VA San Diego Healthcare SystemSan DiegoCalifornia92161
Sonya Norman, PhD
[email protected]
8585188266
VA Tampa Healthcare SystemTampaFlorida33612
Brittany Davis, PhD
[email protected]
813-972-2000
VA Atlanta Healthcare SystemAtlantaGeorgia30033
Kristin Lamp, PhD
[email protected]
Hines VA Healthcare SystemChicagoIllinois60141
Jonathan Bayer, PhD
[email protected]

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