Paid Clinical Trials in Durham, NC

As of June 2026, 1,084 paid clinical trials are recruiting in Durham, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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1,084 clinical trials

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pH1N1 Blinded Challenge Study

for Influenza

2 locations incl. Baltimore

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07110532·Phase 1·Recruiting

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A Phase 2 Open-label Study to Evaluate the Safety of Laruparetigene Zovaparvovec Administered Bilaterally in Male Participants With X-Linked Retinitis Pigmentosa

for X-Linked Retinitis Pigmentosa (XLRP)

6 locations incl. Jacksonville

Sponsor: Beacon Therapeutics

Sex: Male·Age: 12 - 50

Code: NCT07174726·Phase 2·Recruiting

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A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

for Chronic Lymphocytic Leukemia

36 locations incl. Phoenix

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06973187·Phase 3·Recruiting

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A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases

for Refractory Autoimmune Diseases

2 locations incl. Boston

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07115745·Phase 1·Recruiting

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Mobile Intervention for Suicidal Thoughts

for Suicide

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06593379·Recruiting

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A Study of GNTI-122 in Adults Recently Diagnosed With T1D

for Type 1 Diabetes (T1D)

10 locations incl. Duarte

Sponsor: GentiBio, Inc

Sex: All·Age: 18 - 55

Code: NCT06919354·Phase 1·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

for Colorectal Cancer

22 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07023289·Phase 2·Recruiting

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Provider Skill Building for Engagement and Communication in Healthcare - Hypertension Management

for Patient-centered Care

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07147075·Enrolling By Invitation

SNAPS Breast Cancer Patient Study Breast Cancer Patients

for Breast Cancer

1 location in Durham

Sponsor: Immunis.AI

Sex: Female·Age: 18+

Code: NCT05370300·Not Yet Recruiting

Hospital-to-Home Transitional Care Interventions (H2H-TCI) Children/Youth With Special Health Care Needs (CYSHCN)

for Health Care

2 locations incl. Chapel Hill

Sponsor: Duke University

Sex: All·Age: Up to 18

Code: NCT06428175·Recruiting

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Optimizing Timing of Cesarean Delivery Consent on Labor and Delivery

for Pregnancy

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07117708·Recruiting

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A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

for Invasive Mold Infections

15 locations incl. Birmingham

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT06925321·Phase 3·Recruiting

Apply to this trial

An International Observational Study of Adults With Acute Infection

for Infectious Disease

18 locations incl. Tucson

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting

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Enhancing Resilience Among Patients With Stroke: Implementation of High Intensity Home-based Rehabilitation

for Stroke

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07098286·Enrolling By Invitation

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

for Healthy

114 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 1 Day - 49·Accepts healthy volunteers

Code: NCT07160244·Phase 3·Recruiting

Apply to this trial

Telerehabilitation In The Home After Stroke

for Stroke

27 locations incl. Downey

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06682429·Recruiting

Apply to this trial

HCMT/MM2401: Ph2 Study of Selinexor + Bispecific Antibody for RRMM

for Multiple Myeloma in Relapse

Drug: Selinexor

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06822972·Phase 2·Recruiting

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OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

for Cardiovascular Disease

Drug: Olpasiran

204 locations incl. Alexander City

Sponsor: Amgen

Sex: All·Age: 50 - 105

Code: NCT07136012·Phase 3·Recruiting

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AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

for Age-Related Macular Degeneration

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 50 - 89·Accepts healthy volunteers

Code: NCT06619405·Recruiting

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FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

8 locations incl. Sacramento

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting

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A New Intervention to Improve Function in Veterans With Anxiety and Depression

for Anxiety and Depression

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65

Code: NCT06188923·Phase 2·Recruiting

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A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

17 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06948318·Phase 3·Recruiting

Apply to this trial

Pain With Dementia

for Pain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06854718·Recruiting

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Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)

for COPD Acute Exacerbation

22 locations incl. Birmingham

Sponsor: Connect Biopharm LLC

Sex: All·Age: 40 - 80

Code: NCT06940154·Phase 2·Recruiting

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A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

for Polycythemia Vera (PV)

15 locations incl. Phoenix

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT06985147·Phase 2·Recruiting

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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

for Advanced Solid Tumor

18 locations incl. Phoenix

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07070232·Phase 1, Phase 2·Recruiting

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COMPASS Study for Metastatic Castration-resistant Prostate Cancer

for Prostate Cancer

3 locations incl. San Francisco

Sponsor: Duke University

Sex: Male·Age: 18+

Code: NCT07050433·Recruiting

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Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

for X-Linked Chronic Granulomatous Disease

8 locations incl. Los Angeles

Sponsor: Ensoma

Sex: Male·Age: 3 Months+

Code: NCT06876363·Phase 1, Phase 2·Recruiting

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Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting

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Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC

for Metastatic Non-Squamous Non-Small Cell Lung Cancer

6 locations incl. Birmingham

Sponsor: CatalYm GmbH

Sex: All·Age: 18+

Code: NCT07098988·Phase 2·Recruiting

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Detecting Pulmonary Hypertension With the Eko CORE 500 Digital Stethoscope

for Pulmnary Hypertension

2 locations incl. Los Angeles

Sponsor: Eko Devices, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07136623·Recruiting

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AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

for KRAS Altered Advanced or Metastatic Solid Tumors

9 locations incl. Duarte

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07094113·Phase 1·Recruiting

Apply to this trial

Transition Health and Resilience Through Valued Experiences (THRiVE) Pilot for Newly Separated Veterans

for Military Transition

1 location in Durham

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06778278·Recruiting

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Chronic Exogenous Ketosis in HFpEF

for Heart Failure With Preserved Ejection Fraction (HFPEF)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06937320·Phase 2·Enrolling By Invitation

Global Open-Label Extension Study of Del-desiran for the Treatment of DM1

for Myotonic Dystrophy Type 1

17 locations incl. Los Angeles

Sponsor: Avidity Biosciences, Inc.

Sex: All·Age: 16+

Code: NCT07008469·Phase 3·Enrolling By Invitation

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

for Atherosclerotic Cardiovascular Disease

139 locations incl. Daphne

Sponsor: Amgen

Sex: All·Age: 45 - 99

Code: NCT07037433·Phase 3·Recruiting

Apply to this trial

4D Duke Microscope Integrated Optical Coherence Tomography in a Zeiss Artevo 800

for Corneal Diseases

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07024719·Recruiting

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A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

for Pancreatic Neuroendocrine Tumor (pNET)

39 locations incl. Birmingham

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06943755·Phase 2, Phase 3·Recruiting

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Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

for Renal Cell Carcinoma

7 locations incl. San Francisco

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 120

Code: NCT07049926·Phase 1, Phase 2·Recruiting

Apply to this trial