Paid Clinical Trials in Durham, NC

As of June 2026, 1,084 paid clinical trials are recruiting in Durham, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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1,084 clinical trials

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A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

for Atrial Fibrillation

6 locations incl. San Francisco

Sponsor: Bayer

Sex: All·Age: 18 - 85

Code: NCT07625215·Phase 2·Not Yet Recruiting

Virtual Activities of Living for Occupational Rehabilitation

for Stroke

1 location in Durham

Sponsor: Barron Associates, Inc.

Sex: All·Age: 18+

Code: NCT07450586·Not Yet Recruiting

Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors

for ASCVD

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07117695·Not Yet Recruiting

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

for Persistent Corneal Epithelial Defect

18 locations incl. Huntington Beach

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 18+

Code: NCT07519902·Phase 3·Recruiting

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Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF

for Atrial Fibrillation

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04956978·Not Yet Recruiting

Planning Grant for TOPS for Breast Cancer Survivors

for Breast Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 21 - 90

Code: NCT06658912·Not Yet Recruiting

Using Community Health Workers to Support Rural Care Partners of Seriously Ill Older Veterans

for Dementia

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06963970·Not Yet Recruiting

Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain

for Spine

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06987786·Not Yet Recruiting

A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control

for Myopia

12 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 5 - 11

Code: NCT07095894·Phase 3·Recruiting

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Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

for Knee Stiffness After Total Knee Arthroplasty

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT07348614·Phase 4·Recruiting

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Overnight TI in TLE

for Temporal Lobe Epilepsy (TLE)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 70

Code: NCT07434986·Not Yet Recruiting

A Study Testing a Digital, Gamified Early Intervention for Eating Disorders ("FlexED")

for Eating Disorders

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 15 - 25

Code: NCT07632248·Not Yet Recruiting

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress: the Lift RCT

for Critical Illness

3 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419·Not Yet Recruiting

ESP Blocks for Posterior Spinal Fusion

for Postoperative Pain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT07228039·Phase 4·Not Yet Recruiting

Signatera Assessment in Early-Stage Endometrial Cancer

for Endometrial Cancer

9 locations incl. Birmingham

Sponsor: Natera, Inc.

Sex: Female·Age: 18+

Code: NCT07339384·Not Yet Recruiting

Health Enhanced Artery Risk Tracking With Widespread Implementation and Screening Effort in ASCVD (HEARTWISE-ASCVD)

for Atherosclerotic Cardiovascular Disease (ASCVD)

6 locations incl. Los Angeles

Sponsor: Stanford University

Sex: All·Age: 18 - 74

Code: NCT07355894·Not Yet Recruiting

SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

for Healthy Volunteers

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07429292·Phase 4·Not Yet Recruiting

ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant Patients

for Stem Cell Transplant Patients

2 locations incl. Kansas City

Sponsor: Anthony Sung, MD

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07516314·Not Yet Recruiting

Safer Drinking Spaces Study

for Sexual Violence

3 locations incl. Gainesville

Sponsor: RTI International

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07527988·Not Yet Recruiting

ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)

for Coronary Artery Disease

16 locations incl. Phoenix

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT07559903·Not Yet Recruiting

CVFs in SIH: EID vs. PCD CTM

for Spontaneous Intracranial Hypotension

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07582744·Not Yet Recruiting

Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting

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A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

for Pneumococcal Disease

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 42 Days - 211 Days·Accepts healthy volunteers

Code: NCT07629440·Phase 3·Recruiting

Apply to this trial

Stress and Menstrual Health

for Menstrual Dysfunction

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07566260·Recruiting

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A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

for Chronic Graft-versus-host-disease

11 locations incl. Duarte

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 17

Code: NCT07124078·Phase 2·Recruiting

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'Eat Well' Produce Prescription RCT

for Hypertension

1 location in Durham

Sponsor: Institute for Medical Research, Inc.

Sex: All·Age: 18+

Code: NCT07534501·Recruiting

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Adding Asciminib to Usual Treatment for Adults With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia

for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

8 locations incl. Orange

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 60+

Code: NCT06773936·Phase 2·Enrolling By Invitation

AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE

for Hernia

12 locations incl. Loma Linda

Sponsor: Tissium

Sex: All·Age: 22+

Code: NCT07277946·Recruiting

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Study of INCA036978 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

Drug: INCA036978

22 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07441694·Phase 1·Recruiting

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Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors

for Cancer Survivorship

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 39

Code: NCT07471685·Recruiting

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Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

for Smoking

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT07089901·Phase 4·Recruiting

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A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

for Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma

9 locations incl. Los Angeles

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07488676·Phase 1, Phase 2·Recruiting

Apply to this trial

Occlutech AFR Fontan Study

for Failure of Fontan Type Circulation

7 locations incl. Birmingham

Sponsor: Occlutech International AB

Sex: All·Age: All ages

Code: NCT07532369·Not Yet Recruiting

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

for Newly Diagnosed Glioblastoma

1 location in Durham

Sponsor: Mustafa Khasraw, MBChB, MD, FRCP, FRACP

Sex: All·Age: 18+

Code: NCT04903795·Phase 1·Not Yet Recruiting

Implementing a Group Physical Therapy Program for Veterans (GroupPT): Function QUERI 3.0

for Knee Osteoarthritis

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07215572·Recruiting

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Implementing Cognitive Behavioral Therapy for Insomnia (SWELL): Function QUERI 3.0

for Chronic Insomnia

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 60+

Code: NCT07216261·Recruiting

Apply to this trial

Implementing a Mobile Health Application for Women Veterans With Urinary Incontinence (MyHealtheBladder): Function QUERI 3.0

for Urinary Incontinence

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: Female·Age: All ages

Code: NCT07219433·Recruiting

Apply to this trial

Assessment of Topical Minoxidil on Intraoperative Flap Perfusion and Cutaneous Flap Viability in Breast Recon

for Breast Reconstruction

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07264790·Phase 1·Recruiting

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Studies of Insulin and Glucagon Action in the Liver

for Diabetes (DM)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07300982·Phase 1, Phase 2·Not Yet Recruiting

A Study to Evaluate the Use of Resmetirom in Participants With MASLD and HIV

for MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

10 locations incl. Birmingham

Sponsor: Naga P. Chalasani

Sex: All·Age: 18+

Code: NCT07143968·Phase 2·Recruiting

Apply to this trial