Heart disease Clinical Trials in Durham, NC

As of June 2026, 60 paid clinical trials are recruiting for Heart disease in Durham, North Carolina. Heart disease research tests new drug therapies, device-based interventions, and lifestyle programs for heart failure, atrial fibrillation, hypertension, and coronary disease — including therapies that reduce hospitalization and cardiovascular death. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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60 clinical trials for Heart disease

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The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

for Coronary Artery Disease

9 locations incl. Birmingham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05618353·Phase 4·Recruiting

Apply to this trial

Goal Concordant Care Learning Laboratory

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05879211·Enrolling By Invitation

Supporting Health in Veterans With Heart Failure

for Heart Failure

4 locations incl. Gainesville

Sponsor: Florida State University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05839067·Recruiting

Apply to this trial

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

184 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05636176·Phase 3·Recruiting

Apply to this trial

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

Apply to this trial

Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

for Atrial Fibrillation (AF)

Drug: Abelacimab

150 locations incl. Birmingham

Sponsor: Anthos Therapeutics, Inc.

Sex: All·Age: 65+

Code: NCT05712200·Phase 3·Recruiting

Apply to this trial

Ventripoint Single Ventricle Study

for Congenital Heart Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT05262907·Recruiting

Apply to this trial

Addressing Barriers to Achieving Cardiometabolic Disorders Prevention and Treatment Goals for PLWH in the SE US

for Hypertension

2 locations incl. Charlotte

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05129345·Recruiting

Apply to this trial

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

for Coronavirus Infection (COVID-19)

49 locations incl. Phoenix

Sponsor: Duke University

Sex: All·Age: 0 - 20·Accepts healthy volunteers

Code: NCT04278404·Recruiting

Apply to this trial

Global Utilization And Registry Database for Improved heArt preservatioN

for Heart Diseases

17 locations incl. Stanford

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04141605·Enrolling By Invitation

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

Apply to this trial

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

Apply to this trial

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

for PAH

Drug: Ralinepag

48 locations incl. Phoenix

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT03683186·Phase 3·Enrolling By Invitation

Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients

for Heart Failure

3 locations incl. Los Angeles

Sponsor: Baylor Research Institute

Sex: All·Age: 18 - 90

Code: NCT03383419·Phase 2·Recruiting

Apply to this trial

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

38 locations incl. Alexander City

Sponsor: Uppsala University

Sex: All·Age: 50 - 99

Code: NCT02901184·Phase 3·Recruiting

Apply to this trial

Observational Pharmaco-Epidemiology Research & Analysis

for Chronic Disease

1 location in Durham

Sponsor: Epividian

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT03813862·Recruiting

Apply to this trial

Product Surveillance Registry

for Cardiac Rhythm Disorders

134 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT01524276·Recruiting

Apply to this trial

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

for Arrhythmia

113 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT00271180·Recruiting

Apply to this trial

Conditions in Heart disease (Durham, NC)

Heart failure· 29 Cardiovascular disease (general)· 11 Hypertension (high blood pressure)· 10 Atrial fibrillation· 7 Coronary artery disease· 7 Congenital heart disease· 3