Clinical Trials at City of Hope Medical Center

As of June 2026, 172 paid clinical trials are recruiting at City of Hope Medical Center, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (800) 826-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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172 clinical trials at City of Hope Medical Center

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Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma (PROMETHEA Study)

for Hepatocellular Carcinoma (HCC)

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07265271·Recruiting

Apply to this trial

Telehealth Intervention for Ostomy Self-Management

for Colorectal Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06528990·Phase 2·Recruiting

Apply to this trial

CMV-specific HIV-CAR T Cells as Immunotherapy for HIV/AIDS

for HIV-1

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06252402·EARLY_Phase 1·Recruiting

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Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

for Anatomic Stage I Breast Cancer AJCC v8

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: Female·Age: 18+

Code: NCT06763328·Phase 3·Recruiting

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Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

for Acute Leukemia

Drug: Revumenib

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 2+

Code: NCT06575296·Phase 1·Recruiting

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A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab

for Recurrent Mycosis Fungoides

10 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07003100·Recruiting

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Acalabrutinib, Obinutuzumab, and Glofitamab for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Glofitamab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06054776·Phase 2·Recruiting

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A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia

for Recurrent Severe Aplastic Anemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: Up to 75·Accepts healthy volunteers

Code: NCT05757310·Phase 1·Recruiting

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Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07226154·Recruiting

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Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung Carcinoma

for Lung Non-Small Cell Carcinoma

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06014827·Phase 2·Recruiting

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Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial

for Anatomic Stage I Breast Cancer AJCC v8

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 65+

Code: NCT06042569·Phase 2·Recruiting

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Mosunetuzumab and Polatuzumab Vedotin for the Treatment of Patients With Relapsed or Refractory Grade 1-3a Follicular Lymphoma

for Recurrent Grade 1 Follicular Lymphoma

Drug: Polatuzumab Vedotin

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06453044·Phase 2·Recruiting

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Denosumab for Type 1 Diabetes

for Type 1 Diabetes

3 locations incl. Birmingham

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 50

Code: NCT06524960·Phase 1, Phase 2·Recruiting

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Study With [225Ac]Ac-FL-020 in mCRPC Participants

for Metastatic Castration-resistant Prostate Cancer

5 locations incl. Duarte

Sponsor: Full-Life Technologies GmbH

Sex: Male·Age: 18+

Code: NCT06492122·Phase 1·Recruiting

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High Cannabidiol Plant Extract (BRC-001) to Improve Aromatase Inhibitor-Induced Arthralgia in Women With Breast Cancer

for Anatomic Stage 0 Breast Cancer AJCC v8

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Female·Age: 18+

Code: NCT06538389·Phase 2·Recruiting

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Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases

for Metastatic Malignant Neoplasm in the Bone

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06549478·Phase 1·Recruiting

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Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06260033·Phase 2·Recruiting

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PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer

for Castration-Resistant Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT05805371·Phase 1·Recruiting

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Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

Drug: Ruxolitinib

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 2 - 22

Code: NCT06128070·Phase 2·Recruiting

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Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation

for Thyroid Gland Follicular Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06440850·Phase 2·Recruiting

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CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

for Acute Lymphoblastic Leukemia

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06059391·Phase 2·Recruiting

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Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy

for Advanced Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 60+

Code: NCT05869682·Phase 2·Recruiting

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Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer

for Gastric Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT06408220·Recruiting

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cfDNA 5mC/5hmC Biomarkers to Predict Chemotherapy Response in Metastatic Colorectal Cancer

for CRC (Colorectal Cancer)

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07224815·Recruiting

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Development of a cfDNA 5mC/5hmC-based Biomarker Panel to Predict Targeted Therapy Efficacy in mCRC

for CRC (Colorectal Cancer)

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07224841·Recruiting

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Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer

for Colorectal Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 80

Code: NCT07226115·Recruiting

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CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer

for Advanced Clear Cell Renal Cell Carcinoma

Drug: Ipilimumab

1 location in Duarte

Sponsor: Osel, Inc.

Sex: All·Age: 18+

Code: NCT06399419·Phase 1·Recruiting

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A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

for Leukemia

13 locations incl. Duarte

Sponsor: BlossomHill Therapeutics

Sex: All·Age: 18+

Code: NCT06501196·Phase 1·Recruiting

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Comparing the Impact of Four Types of Meditation Practices for Relaxation in Cancer Survivors

for Hematopoietic and Lymphatic System Neoplasm

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06500377·Recruiting

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Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases

for Colorectal Cancer Liver Metastases (CRLM)

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07224724·Recruiting

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Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT06195891·Phase 1·Recruiting

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Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy

for Lung Non-Small Cell Carcinoma

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT06139627·Recruiting

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A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias

for Acute Myeloid Leukemias

26 locations incl. Burbank

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06226571·Phase 1·Recruiting

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Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer

for Advanced Pancreatic Adenocarcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06454383·Phase 1·Recruiting

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Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

for Advanced Lung Non-Small Cell Carcinoma

Drug: Sotorasib

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06249282·Phase 1·Recruiting

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Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma

for Multiple Myeloma

Drug: Mezigdomide

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06048250·Phase 1·Recruiting

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An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

for Hepatocellular Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06342414·Recruiting

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A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes

for Acute Myeloid Leukemia

8 locations incl. Duarte

Sponsor: GluBio Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06146257·Phase 1·Recruiting

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Loncastuximab Tesirine and Mosunetuzumab for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

for Recurrent Diffuse Large B-Cell Lymphoma

Drug: Mosunetuzumab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05672251·Phase 2·Recruiting

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CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia

for Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05672147·Phase 1·Recruiting

Apply to this trial