Clinical Trials at City of Hope Medical Center

As of June 2026, 172 paid clinical trials are recruiting at City of Hope Medical Center, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (800) 826-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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172 clinical trials at City of Hope Medical Center

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Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer

for Advanced Clear Cell Renal Cell Carcinoma

Drug: Ipilimumab

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07128680·Phase 1·Recruiting

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177^Lu-PSMA-617 in Combination With Sipuleucel-T for the Treatment of Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration-Resistant Prostate Adenocarcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT07219147·Phase 1·Recruiting

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Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors

for Hearing Loss

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT07218913·Phase 1·Recruiting

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Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells

for Recurrent Diffuse Large B-Cell Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07042438·Phase 2·Recruiting

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Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Drug: Cemiplimab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06860815·Phase 2·Recruiting

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Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial

for Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 30 - 79

Code: NCT07202247·Phase 2·Recruiting

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A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients

for Multiple Myeloma

11 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225738·Recruiting

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Digital Health Intervention for Self-Management and Telemonitoring in Chimeric Antigen Receptor (CAR-T) Therapy

for Hematologic Malignancies

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07186192·Phase 3·Recruiting

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A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

for Solid Tumors

8 locations incl. Duarte

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07195916·Phase 1·Recruiting

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Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

for Chronic Lymphocytic Leukemia

Drug: Epcoritamab

7 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07218510·Phase 2·Recruiting

Apply to this trial

Individualized AML Treatment

for Relapsed/Refractory Acute Myeloid Leukemia (AML)

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07613385·Recruiting

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Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06735690·EARLY_Phase 1·Recruiting

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Ruxolitinib in Combination With CHOP Chemotherapy for the Treatment of Untreated Nodal T-Follicular Helper Cell Lymphomas

for Follicular Helper T-Cell Lymphoma

Drug: Ruxolitinib

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07278856·Phase 1·Recruiting

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Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

29 locations incl. Anchorage

Sponsor: Incyte Corporation

Sex: Female·Age: 18+

Code: NCT07214779·Phase 3·Recruiting

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Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R)

for Prostate Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT07210086·Phase 2·Recruiting

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Nab-Paclitaxel PIPAC in Combination With Paclitaxel and Ramucirumab for the Treatment of Stomach Cancer With Peritoneal Metastases

for Clinical Stage IVB Gastric Cancer AJCC v8

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06675136·Phase 1·Recruiting

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Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

8 locations incl. Phoenix

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 54

Code: NCT06918431·Phase 2·Recruiting

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Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

for Breast Carcinoma

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06731894·Phase 2·Recruiting

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A Study of GNTI-122 in Adults Recently Diagnosed With T1D

for Type 1 Diabetes (T1D)

10 locations incl. Duarte

Sponsor: GentiBio, Inc

Sex: All·Age: 18 - 55

Code: NCT06919354·Phase 1·Recruiting

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External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease

for Extramedullary Disease in Multiple Myeloma

Drug: Talquetamab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06572605·Phase 1, Phase 2·Recruiting

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Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

7 locations incl. Arcadia

Sponsor: City of Hope Medical Center

Sex: Female·Age: 40+

Code: NCT06954831·Phase 2·Recruiting

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Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Drug: Sonrotoclax

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06859008·Phase 1·Recruiting

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Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation

for Recurrent Transformed Chronic Lymphocytic Leukemia

Drug: Odronextamab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06735664·Phase 1·Recruiting

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A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia

for Recurrent Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06763341·Phase 1·Recruiting

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Glofitamab With Obinutuzumab Pre-treatment for the Treatment of Central Nervous System Lymphoma

for Primary Central Nervous System Lymphoma

Drug: Glofitamab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06922604·Phase 1·Recruiting

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Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

for Breast Cancer

22 locations incl. Duarte

Sponsor: Celcuity Inc

Sex: All·Age: 18+

Code: NCT06757634·Phase 3·Recruiting

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Aromatherapy Essential Oils to Manage Anxiety and Nausea in Cancer Patients Receiving Infusion in the Ambulatory Setting

for Hematopoietic and Lymphatic System Neoplasm

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07126301·Recruiting

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225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

Drug: Daratumumab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06287944·Phase 1·Recruiting

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Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers

for Head and Neck Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06985784·Recruiting

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Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

for Recurrent Astrocytoma, IDH-Mutant, Grade 3

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06815029·Phase 1·Recruiting

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FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

for Rectal Adenocarcinoma

Drug: Botensilimab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06780787·Phase 2·Recruiting

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Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06910761·Phase 2·Recruiting

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Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

for Acute Lymphoblastic Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 80

Code: NCT06815003·Phase 2·Recruiting

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Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

for Locally Advanced Rectal Adenocarcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06834126·Phase 1·Recruiting

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Tagraxofusp and Azacitidine for Maintenance Treatment in Patients With CD123 Positive AML and MDS Following Donor Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75

Code: NCT06498973·Phase 1·Recruiting

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Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Nemtabrutinib

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06572618·Phase 2·Recruiting

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Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06543381·Phase 1·Recruiting

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Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA

for Colorectal Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07224789·Recruiting

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Detection of Minimal Residual Disease Using Exosomal miRNA Distant Metastasis Markers

for Gastric Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07243015·Recruiting

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An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer

for Colon Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07255729·Recruiting

Apply to this trial