Clinical Trials at Cleveland Clinic

As of June 2026, 375 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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375 clinical trials at Cleveland Clinic

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Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma

for Low Grade Upper Tract Urothelial Carcinoma

7 locations incl. Lisle

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT07265947·Phase 2·Recruiting

Apply to this trial

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma (PDAC)

14 locations incl. Cerritos

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217717·Phase 3·Recruiting

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Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support

for Choline Deficiency

7 locations incl. Aurora

Sponsor: Protara Therapeutics

Sex: All·Age: 12+

Code: NCT06910943·Phase 2, Phase 3·Recruiting

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A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

for Chronic Kidney Disease

Drug: Empagliflozin

30 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 2 - 17

Code: NCT07107945·Phase 3·Recruiting

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Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

29 locations incl. Anchorage

Sponsor: Incyte Corporation

Sex: Female·Age: 18+

Code: NCT07214779·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

for Parkinson's Disease

Drug: Prasinezumab

42 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 85

Code: NCT07174310·Phase 3·Recruiting

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Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

for Parkinson Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07110376·Recruiting

Apply to this trial

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

for Post Operative Pain

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 72·Accepts healthy volunteers

Code: NCT07222072·Phase 4·Recruiting

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Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

for Esophageal Cancer

14 locations incl. Cerritos

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217704·Phase 3·Recruiting

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A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

14 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting

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A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart

21 locations incl. Little Rock

Sponsor: Vasa Therapeutics

Sex: All·Age: 50+

Code: NCT07219511·Phase 1·Recruiting

Apply to this trial

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Bevacizumab

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701656·Phase 2·Recruiting

Apply to this trial

Care in Multiple Sclerosis (MS)

for Multiple Sclerosis

6 locations incl. Birmingham

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07011914·Recruiting

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A Two-Part Phase 3 Study of Sofetabart Mipitecan (LY4170156) in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Part B) Ovarian Cancer

for Ovarian Neoplasms

82 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213804·Phase 3·Recruiting

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A Study to Evaluate Efficacy and Safety of Ciltacabtagene Autoleucel

for Multiple Myeloma

5 locations incl. San Francisco

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 80

Code: NCT07149857·Phase 2·Recruiting

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Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

for Urothelial Cancer

35 locations incl. Gilbert

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07106762·Phase 2, Phase 3·Recruiting

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A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons

for Open Surgery

4 locations incl. Beverly Hills

Sponsor: MMI (Medical Microinstruments, Inc.)

Sex: All·Age: 22+

Code: NCT06725030·Recruiting

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GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

for Aortic Dissection

16 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06827990·Recruiting

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A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

for Interstitial Lung Diseases

Drug: Nerandomilast

33 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06806592·Phase 3·Recruiting

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Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

for Atrial Fibrillation (AF)

18 locations incl. Birmingham

Sponsor: Arga Medtech SA

Sex: All·Age: 18 - 80

Code: NCT06784466·Recruiting

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Validation of Donor-Derived Cell-Free DNA (Dd-cfDNA) for Kidney Transplant Monitoring

for Kidney Transplant Rejection

8 locations incl. Los Angeles

Sponsor: Insight Molecular Diagnostics

Sex: All·Age: 18+

Code: NCT07060716·Recruiting

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Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for Solid Tumor Malignancies

13 locations incl. Denver

Sponsor: Tasca Therapeutics

Sex: All·Age: 18+

Code: NCT07030257·Phase 1, Phase 2·Recruiting

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Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

for Afib

2 locations incl. Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT07087587·Recruiting

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A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer

for Non Small Cell Lung Cancer

8 locations incl. Oxnard

Sponsor: Wayshine Biopharm, Inc.

Sex: All·Age: 18+

Code: NCT06868485·Phase 2·Recruiting

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A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

for Polycythemia Vera (PV)

15 locations incl. Phoenix

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT06985147·Phase 2·Recruiting

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Zimmer ActivBraid Rotator Cuff Repair (RCR) Study

for Rotator Cuff Repair of the Shoulder

2 locations incl. Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 75

Code: NCT06971497·Recruiting

Apply to this trial

HOPE Against Cancer Recurrence in HCC

for Liver Transplantation

2 locations incl. New York

Sponsor: Philipp Dutkowski

Sex: All·Age: 18+

Code: NCT06717919·Phase 4·Recruiting

Apply to this trial

A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK

for Macular Edema Secondary to Inflammation

55 locations incl. Phoenix

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06990399·Phase 3·Recruiting

Apply to this trial

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

for Adjustment Disorder

30 locations incl. Birmingham

Sponsor: Reunion Neuroscience Inc

Sex: All·Age: 18 - 80

Code: NCT07002034·Phase 2·Recruiting

Apply to this trial

BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease

for Parkinson Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 40+

Code: NCT07138560·Phase 4·Recruiting

Apply to this trial

Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

for Familial Adenomatous Polyposis (FAP)

18 locations incl. Arcadia

Sponsor: Rapamycin Holdings Inc.

Sex: All·Age: 18+

Code: NCT06950385·Phase 3·Recruiting

Apply to this trial

A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE

for Macular Edema Secondary to Inflammation

55 locations incl. Phoenix

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06996080·Phase 3·Recruiting

Apply to this trial

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

for Lupus Erythematosus, Systemic

Drug: BMS-986353

40 locations incl. Scottsdale

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 16+

Code: NCT07015983·Phase 2·Recruiting

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The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

for Ischemic Heart Disease (IHD)

12 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 85

Code: NCT06854458·Recruiting

Apply to this trial

Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

for Moderate Aortic Valve Stenosis

Drug: Ataciguat

66 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 50+

Code: NCT07001800·Phase 2, Phase 3·Recruiting

Apply to this trial

Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension

for Pulmonary Arterial Hypertension

Drug: Empagliflozin

3 locations incl. Baltimore

Sponsor: Gustavo A Heresi, MD, MS

Sex: All·Age: 18+

Code: NCT06992440·Phase 2·Enrolling By Invitation

A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

for Solid Tumor Malignancies

15 locations incl. Phoenix

Sponsor: Kumquat Biosciences Inc.

Sex: All·Age: 18+

Code: NCT06994806·Phase 1·Recruiting

Apply to this trial

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701682·Phase 2·Recruiting

Apply to this trial

Safety and Efficacy of Endovascular Treatment of Intracranial Aneurysms With Surpass Elite With GUARDian Flow Diverter (GUARD)

for Aneurysm

10 locations incl. Tucson

Sponsor: Stryker Neurovascular

Sex: All·Age: 18 - 80

Code: NCT06872684·Recruiting

Apply to this trial

Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia

for Ventricular Tachycardia

1 location in Cleveland

Sponsor: Pasquale Santangeli

Sex: All·Age: 18+

Code: NCT06891456·Recruiting

Apply to this trial