Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT07087587
Status
Recruiting
Apply to this trial

Conditions

  • Afib
  • CPAP
  • Sleep Apnea Syndrome, Obstructive

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • CPAP — DEVICE
    CPAP will be randomized 2 weeks on 2 weeks off for 12 weeks total

Study Details

A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).

Key Dates

Start date
Aug 25, 2025
Status verified
Oct 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Alternating CPAP vs. No Treatment
    Each participant undergoes alternating 2-week periods of CPAP treatment and no treatment over approximately 13 weeks. This personalized intervention evaluates changes in AF burden and quality of life, with patients serving as their own controls.

Primary Outcome Measure

Change in Average Daily AF Burden (%) [ Time Frame: Up to 13 weeks (duration of each patient's participation) ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Cleveland ClinicClevelandOhio44195-
University of WashingtonSeattleWashington98195
Reena Mehra, MD
[email protected]
216-272-7405

Find similar trials in Cleveland, OH

By condition
Atrial fibrillation
By specialty
CardiologyHeart disease
By research site
Cleveland Clinic· Cleveland, OHUniversity of Washington· Seattle, WA

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