Neurology Clinical Trials in Chicago, IL

As of June 2026, 122 paid clinical trials are recruiting for Neurology in Chicago, Illinois. Neurology trials investigate disease-modifying therapies for Alzheimer's, Parkinson's, multiple sclerosis, ALS, and stroke recovery alongside symptomatic treatments for epilepsy, migraine, and cognitive decline. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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122 clinical trials for Neurology

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Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

for Huntington Disease

13 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 60

Code: NCT06667414·Recruiting

Apply to this trial

Effect of Neural Constraints on Movement in Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06666673·EARLY_Phase 1·Recruiting

Apply to this trial

EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment

for Ischemic Stroke

14 locations incl. Downey

Sponsor: BrainQ Technologies Ltd.

Sex: All·Age: 22 - 80

Code: NCT06386874·Recruiting

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RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

for Alzheimer Disease

1 location in Chicago

Sponsor: Zaparackas and Knepper LTD

Sex: All·Age: 50 - 90·Accepts healthy volunteers

Code: NCT06470061·Phase 2·Not Yet Recruiting

Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06516458·Recruiting

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A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

for Generalized Myasthenia Gravis

Drug: Iptacopan

21 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT06517758·Phase 3·Recruiting

Apply to this trial

ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting

Apply to this trial

PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting

Apply to this trial

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

for Relapsing Multiple Sclerosis

87 locations incl. Birmingham

Sponsor: TG Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06433752·Recruiting

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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

for Stroke

13 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05907629·Recruiting

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A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

for Parkinson Disease

27 locations incl. Irvine

Sponsor: AskBio Inc

Sex: All·Age: 45 - 75

Code: NCT06285643·Phase 2·Recruiting

Apply to this trial

Study of ALTO-101 in Patients With Schizophrenia

for Schizophrenia

14 locations incl. Garden Grove

Sponsor: Alto Neuroscience

Sex: All·Age: 21 - 55

Code: NCT06502964·Phase 2·Recruiting

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Neuronal and Network Mechanisms of Electrocortical Stimulation

for Epilepsy

3 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT06391294·Enrolling By Invitation

Intermittent Hypoxia in Persons With Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06276634·Recruiting

Apply to this trial

Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device

for Multiple Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06410261·Recruiting

Apply to this trial

Characterization and Clinical Trial of a Variable Friction Shoe

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT06234124·Recruiting

Apply to this trial

Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury

for Spinal Cord Injuries

2 locations incl. Chicago

Sponsor: Milap Sandhu

Sex: All·Age: 16 - 75

Code: NCT06176833·Recruiting

Apply to this trial

Strategy for Improving Stroke Treatment Response

for Ischemic Stroke

52 locations incl. Birmingham

Sponsor: Translational Sciences, Inc.

Sex: All·Age: 18+

Code: NCT05948566·Phase 2·Recruiting

Apply to this trial

Nomad P-KAFO Study

for Cerebrovascular Accident

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 89

Code: NCT05644522·Recruiting

Apply to this trial

Exercise Strategies in Parkinson's Disease

for Parkinson Disease

7 locations incl. Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 89

Code: NCT06104397·Enrolling By Invitation

The REACTplusNMES Trial: A Double-blinded RCT

for Stroke, Ischemic

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90

Code: NCT06127602·Recruiting

Apply to this trial

Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015)

for Alzheimer Disease

53 locations incl. Phoenix

Sponsor: Cognito Therapeutics, Inc.

Sex: All·Age: 50 - 92

Code: NCT06245031·Enrolling By Invitation

Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial

for Dementia

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 45+

Code: NCT05607732·Recruiting

Apply to this trial

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

25 locations incl. Phoenix

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting

Apply to this trial

MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)

for Stress, Psychological

8 locations incl. Bolingbrook

Sponsor: University of Illinois at Chicago

Sex: All·Age: 45+

Code: NCT06002919·Recruiting

Apply to this trial

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

for LVAD

7 locations incl. San Francisco

Sponsor: International Consortium of Circulatory Assist Clinicians

Sex: All·Age: 18 - 100

Code: NCT06039176·Recruiting

Apply to this trial

Alzheimer's Disease Neuroimaging Initiative 4

for Mild Cognitive Impairment

59 locations incl. Birmingham

Sponsor: University of Southern California

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05617014·Enrolling By Invitation

REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study

for Intra Cerebral Hemorrhage

26 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: All ages

Code: NCT05611918·Enrolling By Invitation

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06598150·Recruiting

Apply to this trial

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 64

Code: NCT05051618·Recruiting

Apply to this trial

Error-enhanced Learning & Recovery in 2 & 3 Dimensions

for Stroke

3 locations incl. Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05180786·Recruiting

Apply to this trial

Neurostimulation for Respiratory Function After Spinal Cord Injury

for Spinal Cord Injuries

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 85

Code: NCT05756894·Recruiting

Apply to this trial

Predict Severe Traumatic Brain Injury

for Traumatic Brain Injury

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06966713·Recruiting

Apply to this trial

Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

for Spinal Cord Injury

2 locations incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05157282·Recruiting

Apply to this trial

Combination Therapy to Improve SCI Recovery.

for Spinal Cord Injuries

2 locations incl. Chicago

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 70

Code: NCT05563103·Recruiting

Apply to this trial

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

for Multiple Sclerosis

12 locations incl. New Haven

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT05285891·Phase 4·Recruiting

Apply to this trial

The Diabetes Prevention Program Outcomes Study AD/ADRD Project

for Diabetes

27 locations incl. Phoenix

Sponsor: Marinella Temprosa

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05704309·Enrolling By Invitation

Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching

for Spinal Cord Injuries

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 80

Code: NCT05424172·Recruiting

Apply to this trial

Alzheimer's National Registry for Treatment and Diagnostics(ALZ-NET)

for Alzheimer Disease

1 location in Chicago

Sponsor: Alzheimer's Disease and Related Disorders Association, Inc

Sex: All·Age: 18+

Code: NCT06170268·Recruiting

Apply to this trial

Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

3 locations incl. Chicago

Sponsor: argenx

Sex: All·Age: 2 - 18

Code: NCT05374590·Phase 2, Phase 3·Enrolling By Invitation

Conditions in Neurology (Chicago, IL)

Stroke· 38 Parkinson's disease· 14 Multiple sclerosis· 14 Alzheimer's disease· 12 Spinal cord injury· 12 Mild cognitive impairment (MCI)· 10 ALS (amyotrophic lateral sclerosis)· 7 Cognitive impairment / decline· 7 Dementia· 6 Myasthenia gravis· 6 Traumatic brain injury (TBI)· 5 Migraine· 4 Epilepsy· 3 Essential tremor· 2 Movement disorders· 2 Huntington disease· 1 Multiple system atrophy· 1