Cardiology Clinical Trials in Chicago, IL

As of June 2026, 93 paid clinical trials are recruiting for Cardiology in Chicago, Illinois. Cardiology trials investigate SGLT-2 inhibitors, myosin modulators, lipid-lowering therapies, anti-inflammatory agents, and device-based interventions across heart failure, hypertension, AFib, and coronary artery disease. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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93 clinical trials for Cardiology

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Intensive Patient Referral and Education Program Prior to Renal Replacement Therapy

for Chronic Kidney Disease

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT06397456·Recruiting

Apply to this trial

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

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ENhancing Exercise With LIGHT to Improve Functioning in PAD

for Peripheral Artery Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06399900·Recruiting

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MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

for Hypertension

1 location in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 40 - 60

Code: NCT06555952·Recruiting

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NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

for Atrial Fibrillation

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40+

Code: NCT06511505·Not Yet Recruiting

UIC Multi-Ethnic DCM Registry

for Heart Failure

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07145138·Recruiting

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A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

for Heart Failure

Drug: Empagliflozin

95 locations incl. Mobile

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06424288·Phase 3·Recruiting

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Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

for Group 2 Pulmonary Hypertension

8 locations incl. Chicago

Sponsor: Gradient Denervation Technologies

Sex: All·Age: 22 - 85

Code: NCT06052072·Enrolling By Invitation

Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone

for Atrial Fibrillation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 20 - 85

Code: NCT06063538·EARLY_Phase 1·Recruiting

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Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors

for Hypertension

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18 - 99

Code: NCT06504914·Recruiting

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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

for Heart Failure

Drug: Finerenone

77 locations incl. Birmingham

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06008197·Phase 3·Recruiting

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Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease

for Chronic Kidney Diseases

Drug: Dapagliflozin

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT05719714·Phase 1, Phase 2·Recruiting

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LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

for Pulmonary Hypertension

41 locations incl. Tucson

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT05983250·Phase 3·Recruiting

Apply to this trial

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

for Hypertension

70 locations incl. Scottsdale

Sponsor: Orchestra BioMed, Inc

Sex: All·Age: 18+

Code: NCT06059638·Recruiting

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Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart Failure

31 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 40 - 85

Code: NCT06122779·Phase 2·Recruiting

Apply to this trial

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

for LVAD

7 locations incl. San Francisco

Sponsor: International Consortium of Circulatory Assist Clinicians

Sex: All·Age: 18 - 100

Code: NCT06039176·Recruiting

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

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SMART Exercise for PAD

for Peripheral Arterial Disease

3 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06032065·Phase 3·Recruiting

Apply to this trial

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

for Heart Failure

47 locations incl. Phoenix

Sponsor: Procyrion

Sex: All·Age: 21+

Code: NCT05677100·Recruiting

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The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

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Cardiac Power Output in Cardiogenic Shock Patients

for Heart Failure

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05700617·EARLY_Phase 1·Recruiting

Apply to this trial

Interactive Computer-adaptive Chronic Kidney Disease Education Program

for Chronic Kidney Diseases

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT06364358·Recruiting

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

Apply to this trial

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

6 locations incl. Sacramento

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting

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BEETroot Juice to Reverse Functional Impairment in PAD

for Peripheral Artery Disease

4 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT05624125·Recruiting

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Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

for Critical Limb Ischemia

30 locations incl. La Jolla

Sponsor: LimFlow, Inc.

Sex: All·Age: 18 - 95

Code: NCT05313165·Recruiting

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His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

14 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting

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Continuation of the nuMoM2b Heart Health Study

for Cardiovascular Diseases

14 locations incl. Orange

Sponsor: RTI International

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05472597·Enrolling By Invitation

EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

for Heart Failure

15 locations incl. Los Angeles

Sponsor: Berlin Heart, Inc

Sex: All·Age: Up to 21

Code: NCT05610787·Enrolling By Invitation

KardiaMobile ECG Monitoring Effects on Health Care Utilization and Patient Experience With Atrial Fibrillation

for Atrial Fibrillation (AF)

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT05407415·Enrolling By Invitation

SELUTION4BTK Trial

for Peripheral Arterial Disease

30 locations incl. Chandler

Sponsor: M.A. Med Alliance S.A.

Sex: All·Age: 18+

Code: NCT05055297·Recruiting

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Role of Adiposomes in Endothelial Dysfunction

for Obesity

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 50

Code: NCT05199454·Recruiting

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Church-based Intervention to Improve Blood Pressure in African Americans

for Hypertension

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT05220332·Recruiting

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

37 locations incl. Fairhope

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting

Apply to this trial

Diabetic Neuropathy in Spinal Cord Stimulator Patients

for Diabetes Mellitus

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04687215·Recruiting

Apply to this trial

The COCOA-PAD II Trial

for Peripheral Artery Disease

3 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 55+

Code: NCT04794530·Phase 3·Recruiting

Apply to this trial

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

19 locations incl. New Haven

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting

Apply to this trial

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

for Atrial Fibrillation

4 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 100

Code: NCT02347111·Phase 4·Recruiting

Apply to this trial

Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

for Aortic Stenosis

55 locations incl. Huntsville

Sponsor: University of British Columbia

Sex: All·Age: All ages

Code: NCT04634240·Recruiting

Apply to this trial

Conditions in Cardiology (Chicago, IL)

Heart failure· 32 Hypertension (high blood pressure)· 22 Cardiovascular disease (general)· 17 Peripheral artery disease· 12 Atrial fibrillation· 11 Pulmonary hypertension· 7 Coronary artery disease· 4 Congenital heart disease· 2