Paid Clinical Trials in Boston, MA

As of June 2026, 3,013 paid clinical trials are recruiting in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,009 clinical trials

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Preoperative Fasting vs. Not Fasting in Critically Ill Patients

for Critical Illness

19 locations incl. Palo Alto

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06751043·Recruiting

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Tracing the Metabolic Flux of Orally Administered NAD+ Precursors

for Healthy Adults

1 location in Boston

Sponsor: Metro International Biotech, LLC

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06882096·Phase 1·Recruiting

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Ultrasound Stimulation for Patients in a Disorder of Consciousness

for Consciousness Disorders

4 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 79

Code: NCT06939348·Recruiting

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T1D Pregnancy & Me

for Diabetes Mellitus, Type 1

10 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+

Code: NCT06959316·Recruiting

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Telehealth Exercise and Mindfulness for Pain in Osteoarthritis - Stage 1B

for Knee Osteoarthritis

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50+

Code: NCT06684587·Recruiting

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A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

for Metastatic Colorectal Cancer

Drug: Bevacizumab

12 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06820463·Phase 2·Recruiting

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A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

for Carcinoma, Non-Small-Cell Lung

Drug: Adagrasib

54 locations incl. Birmingham

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06875310·Phase 3·Recruiting

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Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

for Metastatic Hepatocellular Carcinoma

9 locations incl. Los Angeles

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06915753·Phase 1·Recruiting

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Access Cannulation Trial II

for Dialysis

8 locations incl. Dothan

Sponsor: Voyager Biomedical

Sex: All·Age: 18+

Code: NCT05490225·Recruiting

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TransHealthGUIDE: Transforming Health for Gender-Diverse Young Adults

for Transgender Persons

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 18 - 29·Accepts healthy volunteers

Code: NCT06177600·Recruiting

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Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myeloma

for Recurrent Multiple Myeloma

40 locations incl. Ames

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06232044·Phase 1, Phase 2·Recruiting

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BRAZAN: A Randomized Phase 2 Study of Bendamustine, Rituximab, Cytarabine (AraC) Induction With Zanubrutinib (BRAZAN) Followed by Zanubrutinib/Rituximab +/- Sonrotoclax Maintenance in Treatment-Naïve Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Sonrotoclax

7 locations incl. Phoenix

Sponsor: Christine Ryan

Sex: All·Age: 18+

Code: NCT06854003·Phase 2·Recruiting

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Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

for Peripheral Arterial Diseases

9 locations incl. Phoenix

Sponsor: Angiodynamics, Inc.

Sex: All·Age: All ages

Code: NCT06777901·Phase 4·Recruiting

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Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine

for Chronic Migraine

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06795867·Recruiting

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A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

for Lupus Erythematosus, Systemic

15 locations incl. San Francisco

Sponsor: AstraZeneca

Sex: All·Age: 18 - 70

Code: NCT06897930·Phase 1, Phase 2·Recruiting

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Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

for Depression

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: Female·Age: 15+·Accepts healthy volunteers

Code: NCT05624931·Recruiting

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Improving Coronary Vascular Health in Women

for HIV-1-infection

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45 - 75

Code: NCT06843902·Phase 2·Recruiting

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A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

for Multiple Sclerosis

8 locations incl. Boston

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18 - 55

Code: NCT06735248·Phase 2·Recruiting

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A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

for RSV Infection

81 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT06866405·Phase 3·Recruiting

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A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

for Tumor Hyperinsulinism (Tumor HI)

8 locations incl. Chicago

Sponsor: Rezolute

Sex: All·Age: 18+

Code: NCT06881992·Phase 3·Recruiting

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Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation

for Healthy Volunteer Study

1 location in Boston

Sponsor: General Biophysics LLC

Sex: All·Age: 55 - 75·Accepts healthy volunteers

Code: NCT06945614·Phase 1·Recruiting

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Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

40 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06966401·Phase 3·Recruiting

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A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

146 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting

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Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

for Multiple Sclerosis

1 location in Boston

Sponsor: University of Massachusetts, Boston

Sex: All·Age: 18+

Code: NCT06554340·Recruiting

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Precision Medicine in the CICU: Identifying Proteomic Biomarkers

for Congenital Heart Disease

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 2 Days - 5

Code: NCT06642662·Enrolling By Invitation

Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

11 locations incl. San Diego

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting

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A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

for Ovarian Cancer Recurrent

8 locations incl. New Haven

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT06843447·Phase 1, Phase 2·Recruiting

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Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

for Glioblastoma (GBM)

3 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06835803·Phase 2·Recruiting

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A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

for Lymphoma, Large B-Cell, Diffuse

Drug: Polatuzumab Vedotin

70 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06890884·Phase 2·Recruiting

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Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]

for Pleural Effusion Associated With Pulmonary Infection

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06713382·Phase 2·Recruiting

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The DIAGNOSE CTE Research Project-II

for Chronic Traumatic Encephalopathy (CTE)

5 locations incl. Phoenix

Sponsor: Boston University

Sex: Male·Age: 50+·Accepts healthy volunteers

Code: NCT06860828·Enrolling By Invitation

Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS

for Unstable Blood Pressure

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 24 Weeks - 44 Weeks

Code: NCT06994494·Recruiting

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Muscle Health Measurements Using Electrical Impedance Myography

for Myopathy

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT07502989·Recruiting

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Assessing the Efficacy of Repeat, Monthly Treatments of Deoxycholate for NF1 Associated Cutaneous Neurofibromas (cNFs)

for Neurofibromas, Cutaneous

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT06300502·Phase 1·Enrolling By Invitation

Remote Tai Chi for Knee Osteoarthritis

for Knee Osteoarthritis

1 location in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 50 - 100

Code: NCT06384898·Recruiting

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Proof-of-Concept Testing of the Cardiovascular Health Equity Through Food (CHEF) Intervention in Childhood Cancer Survivors

for Childhood Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: Up to 18

Code: NCT06609473·Recruiting

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AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

for ALS

10 locations incl. La Jolla

Sponsor: Amylyx Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06665165·Phase 1·Recruiting

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CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

21 locations incl. Phoenix

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting

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TMS for Cognitive Decline in Aging and Preclinical AD

for Prodromal Alzheimer&#39

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06956300·Recruiting

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Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age

for Hyperkalemia

Drug: patiromer

13 locations incl. Aurora

Sponsor: Vifor Pharma, Inc.

Sex: All·Age: 0 - 11

Code: NCT05766839·Phase 2·Recruiting

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