Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

for Graft-versus-host Disease (GVHD)

Drug: Ruxolitinib

30 locations incl. Palo Alto

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06615050·Phase 3·Recruiting

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G-CSF After Chemo-radiation in Patients With Glioblastoma

for MGMT-Methylated Glioblastoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06649851·Phase 2·Recruiting

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EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations

for Lung Cancer

6 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT06716580·Recruiting

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Risk Informed Obesity Care Plan Pilot

for Childhood Obesity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 2 - 12

Code: NCT07028814·Enrolling By Invitation

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

for Non-Small Cell Lung Cancer

16 locations incl. Los Angeles

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06917079·Phase 1·Recruiting

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Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients

for Exocrine Pancreatic Insufficiency (EPI)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06691893·Phase 3·Recruiting

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A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

for Gastrointestinal Stromal Tumor (GIST)

32 locations incl. Birmingham

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06655246·Phase 1·Recruiting

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Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea

for FHA (Functional Hypothalamic Amenorrhea)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 14 - 30

Code: NCT06533865·Phase 3·Recruiting

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Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

for Ovarian Cancer

Drug: Bevacizumab

28 locations incl. La Jolla

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT06819007·Phase 3·Recruiting

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Mg OSTEOCRETE Post-Treatment Outcomes

for Cancer of Bone

1 location in Boston

Sponsor: Santiago Lozano-Calderon

Sex: All·Age: 18+

Code: NCT06720142·Recruiting

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Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA

for ANCA Associated Vasculitis (AAV)

11 locations incl. Aurora

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06868290·Phase 2·Recruiting

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EIM Via the Myolex mScan as an ALS Biomarker

for Amyotrophic Lateral Sclerosis

6 locations incl. Phoenix

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06491732·Recruiting

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Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

for Orthopaedic Trauma

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT06201676·Phase 4·Recruiting

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A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

18 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06722235·Phase 3·Recruiting

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Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors

for Suicide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05671133·Recruiting

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A Study of HLD-0915 in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)

for Prostate Cancer Metastatic Disease

10 locations incl. Denver

Sponsor: Halda Therapeutics OpCo, Inc.

Sex: Male·Age: 18+

Code: NCT06800313·Phase 1, Phase 2·Recruiting

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SNV4818 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

5 locations incl. Los Angeles

Sponsor: Pikavation Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06736704·Phase 1, Phase 2·Recruiting

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MB-105 in Patients With CD5 Positive T-cell Lymphoma

for Lymphoma, T-Cell

12 locations incl. San Diego

Sponsor: March Biosciences Inc

Sex: All·Age: 18+

Code: NCT06534060·Phase 2·Recruiting

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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

for Aortic Stenosis

71 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18 - 105

Code: NCT06777368·Recruiting

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AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

for Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF)

25 locations incl. Fairhope

Sponsor: Cytokinetics

Sex: All·Age: 40 - 85

Code: NCT06793371·Phase 2·Recruiting

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Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)

for Systemic Sclerosis (SSc)

6 locations incl. La Jolla

Sponsor: Zura Bio Inc

Sex: All·Age: 18 - 75

Code: NCT06843239·Phase 2·Recruiting

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ARC101 in Advanced Solid Tumors

for Advanced Solid Tumor

3 locations incl. Boston

Sponsor: Third Arc Bio

Sex: All·Age: 18+

Code: NCT06672185·Phase 1·Recruiting

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Combined Anabolic Therapy

for Osteoporosis, Postmenopausal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45+·Accepts healthy volunteers

Code: NCT06558188·Phase 4·Recruiting

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Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting

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A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

for NonSegmental Vitiligo

Drug: Ruxolitinib

80 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 11

Code: NCT06548360·Phase 3·Recruiting

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Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

for Depressive Disorder, Major

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 25 - 50

Code: NCT06136546·Phase 2·Recruiting

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Advanced Imaging for Pulmonary Fibrosis

for Pulmonary Fibrosis

1 location in Boston

Sponsor: Peter Caravan

Sex: All·Age: 18 - 80

Code: NCT06532071·Phase 2·Recruiting

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A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

for Chronic Graft-versus-host-disease

33 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06585774·Phase 3·Recruiting

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Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

for Insomnia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT06375265·Recruiting

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A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

for Acute Myeloid Leukemia

Drug: Venetoclax

24 locations incl. Los Angeles

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06456463·Phase 2·Recruiting

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SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

for Melanoma, Cutaneous Malignant

40 locations incl. Phoenix

Sponsor: Immatics US, Inc.

Sex: All·Age: 18+

Code: NCT06743126·Phase 3·Recruiting

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Post-Market Clinical Investigation Plan- Collagen Dural Regeneration Matrix (DuraMatrix-Onlay Plus)

for Repair of Dura Mater

2 locations incl. Augusta

Sponsor: Collagen Matrix

Sex: All·Age: 18+

Code: NCT06802133·Recruiting

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Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+

Code: NCT06246929·Recruiting

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A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

for NSCLC (Advanced Non-small Cell Lung Cancer)

23 locations incl. Phoenix

Sponsor: BlossomHill Therapeutics

Sex: All·Age: 18+

Code: NCT06706076·Phase 1, Phase 2·Recruiting

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Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

for Delirium

14 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06192615·Phase 3·Recruiting

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The Effect of Thalamic Stimulation on Sleep Oscillations

for Sleep

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5 - 85

Code: NCT07217080·Enrolling By Invitation

RAPA-501 Therapy for ALS

for Amyotrophic Lateral Sclerosis

1 location in Boston

Sponsor: Rapa Therapeutics LLC

Sex: All·Age: 18+

Code: NCT04220190·Phase 2, Phase 3·Recruiting

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Genetic and Environmental Risk Factors for Hemorrhagic Stroke

for Stroke

7 locations incl. Chicago

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00682695·Recruiting

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Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

for Bipolar Depression

4 locations incl. Boston

Sponsor: Wayne Goodman MD

Sex: All·Age: 22 - 64

Code: NCT06599099·Recruiting

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Efficacy of Synchronous, Virtual Cognitive Behavioral Therapy for Insomnia Across Phases of Cancer Survivorship

for Insomnia Chronic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT06807086·Recruiting

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