Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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Healthy volunteers only

726 clinical trials at Massachusetts General Hospital

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HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

for Cirrhosis

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05205954·Recruiting

Apply to this trial

Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

for Hiv

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06001814·Recruiting

Apply to this trial

A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

14 locations incl. Augusta

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting

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A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

for Systemic Lupus Erythematosus

Drug: Inebilizumab

17 locations incl. Scottsdale

Sponsor: Amgen

Sex: All·Age: 18 - 75

Code: NCT06570798·Phase 2·Recruiting

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Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

for HIV-1-infection

2 locations incl. Aurora

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80

Code: NCT06554717·Phase 2·Recruiting

Apply to this trial

Omalizumab Weight-Based Dosing Efficacy Trial

for Allergies

Drug: Omalizumab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 1 - 55

Code: NCT06943534·Phase 2·Recruiting

Apply to this trial

Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

for Moderate Aortic Valve Stenosis

Drug: Ataciguat

66 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 50+

Code: NCT07001800·Phase 2, Phase 3·Recruiting

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A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

for Pancreatic Ductal Adenocarcinoma

13 locations incl. Los Angeles

Sponsor: Verastem, Inc.

Sex: All·Age: 18+

Code: NCT07020221·Phase 1, Phase 2·Recruiting

Apply to this trial

The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

for Bronchiectasis

80 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT06872892·Phase 3·Recruiting

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The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium

for Delirium, Postoperative

3 locations incl. Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 60+

Code: NCT06721819·Phase 3·Recruiting

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Outpatient Epcoritamab as 2L in NTE R/R DLBCL

for Relapsed Large B-cell Lymphoma

Drug: Epcoritamab

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06811272·Phase 2·Recruiting

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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

for Dravet Syndrome

Drug: zorevunersen

31 locations incl. Phoenix

Sponsor: Stoke Therapeutics, Inc

Sex: All·Age: 2 - 17

Code: NCT06872125·Phase 3·Recruiting

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Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

for Persistent Atrial Fibrillation

32 locations incl. Mobile

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06735534·Recruiting

Apply to this trial

Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance

for Crohn Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07033208·Recruiting

Apply to this trial

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

for Cystic Fibrosis (CF)

13 locations incl. Orange

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18 Months - 11

Code: NCT07048574·Recruiting

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A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE)

for Venous Leg Ulcer (VLU)

14 locations incl. Fresno

Sponsor: MediWound Ltd

Sex: All·Age: 18+

Code: NCT06568627·Phase 3·Recruiting

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Assessing Tenapanor as a Treatment of CF-related Constipation.

for Cystic Fibrosis

Drug: Tenapanor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT06810167·Phase 3·Recruiting

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Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

for PDAC

18 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06922591·Phase 1, Phase 2·Recruiting

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Tolerance Through Mixed Chimerism (Sip-Tego)

for Kidney Failure

1 location in Boston

Sponsor: Tatsuo Kawai, MD, PhD

Sex: All·Age: 18 - 65

Code: NCT06972069·EARLY_Phase 1·Recruiting

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Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

21 locations incl. Birmingham

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06787612·Phase 2·Recruiting

Apply to this trial

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

for Hypertension

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT06557005·Recruiting

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Flotufolastat F 18 PET in Men With Very Low PSA Recurrence

for Prostate Cancer (Adenocarcinoma)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18+

Code: NCT06862856·Recruiting

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Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT

for Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 77

Code: NCT06910956·Recruiting

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Zanubrutinib, Obinutuzumab, and Sonrotoclax in Previously Untreated Patients With CLL or SLL

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06849713·Phase 2·Recruiting

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

14 locations incl. Duarte

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting

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Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

25 locations incl. Birmingham

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting

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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

for Amyloidosis

Drug: Acoramidis

39 locations incl. La Jolla

Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All·Age: 18 - 75

Code: NCT06563895·Phase 3·Recruiting

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Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TGW101 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

7 locations incl. Scottsdale

Sponsor: Tagworks Pharmaceuticals BV

Sex: All·Age: 18+

Code: NCT06959706·Phase 1·Recruiting

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Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

for Intracerebral Hemorrhage

48 locations incl. Birmingham

Sponsor: Joseph Broderick, MD

Sex: All·Age: 18 - 80

Code: NCT07227246·Phase 3·Recruiting

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Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

for Drug Allergy

6 locations incl. Scottsdale

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT06406114·Phase 2·Recruiting

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The BEACON Trial: Diagnostic Tools for Breast Lymphedema After Treatment for Breast Cancer

for Breast Edema

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT06900023·Enrolling By Invitation

Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: Boston Children's Hospital

Sex: All·Age: 6+

Code: NCT06683092·Recruiting

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Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

for Parkinson Disease

1 location in Boston

Sponsor: Jeffrey S. Schweitzer, MD, PhD

Sex: All·Age: 45 - 80

Code: NCT06687837·Phase 1·Recruiting

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Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease

for Peripheral Arterial Disease (PAD)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07613840·Recruiting

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Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

for Peripheral Arterial Diseases

9 locations incl. Phoenix

Sponsor: Angiodynamics, Inc.

Sex: All·Age: All ages

Code: NCT06777901·Phase 4·Recruiting

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Improving Coronary Vascular Health in Women

for HIV-1-infection

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45 - 75

Code: NCT06843902·Phase 2·Recruiting

Apply to this trial

Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

11 locations incl. San Diego

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting

Apply to this trial

CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

21 locations incl. Phoenix

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting

Apply to this trial

TMS for Cognitive Decline in Aging and Preclinical AD

for Prodromal Alzheimer&#39

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06956300·Recruiting

Apply to this trial

FORWARD CAD IDE Study

for Coronary Arterial Disease (CAD)

28 locations incl. La Jolla

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT06662500·Recruiting

Apply to this trial