Clinical Trials at Brigham and Women's Hospital

As of June 2026, 366 paid clinical trials are recruiting at Brigham and Women's Hospital, located at 75 FRANCIS ST, BOSTON, MA 02115-6110, phone (617) 525-7104 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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366 clinical trials at Brigham and Women's Hospital

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MRI Guided Prostate Biopsy

for Suspected Prostate Cancer

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 30+

Code: NCT06302595·Recruiting

Apply to this trial

Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

for Hypertrophic Cardiomyopathy

10 locations incl. La Jolla

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 75

Code: NCT05836259·Phase 1, Phase 2·Recruiting

Apply to this trial

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

Apply to this trial

A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

for Non-muscle-invasive Bladder Cancer

20 locations incl. Mesa

Sponsor: SURGE Therapeutics

Sex: All·Age: 18+

Code: NCT05710848·Phase 1, Phase 2·Recruiting

Apply to this trial

Lupus Landmark Study: A Prospective Registry and Biorepository

for Systemic Lupus Erythematosus (SLE)

19 locations incl. Birmingham

Sponsor: Lupus Research Alliance

Sex: All·Age: 18 - 110

Code: NCT05934149·Recruiting

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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

18 locations incl. Gilbert

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT05926765·Phase 2·Recruiting

Apply to this trial

Alzheimer's Disease Neuroimaging Initiative 4

for Mild Cognitive Impairment

59 locations incl. Birmingham

Sponsor: University of Southern California

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05617014·Enrolling By Invitation

From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

for Chronic Pain

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT05661903·Phase 2·Recruiting

Apply to this trial

Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

for Head and Neck Squamous Cell Carcinoma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05726370·Phase 2·Recruiting

Apply to this trial

A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

for Myositis

47 locations incl. Glendale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05895786·Phase 3·Recruiting

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LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

10 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting

Apply to this trial

TRUDI: TDXD+Durva in HER2+/Low IBC

for Invasive Breast Cancer

3 locations incl. Boston

Sponsor: Filipa Lynce, MD

Sex: Female·Age: 18+

Code: NCT05795101·Phase 2·Recruiting

Apply to this trial

An Open-label Study of XEN1101 in Epilepsy

for Focal Epilepsy

53 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05718817·Phase 3·Enrolling By Invitation

NAD Augmentation in Diabetes Kidney Disease

for Type2diabetes

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 30+

Code: NCT05759468·Phase 2·Recruiting

Apply to this trial

Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

for Prostate Cancer

5 locations incl. Duarte

Sponsor: Varian, a Siemens Healthineers Company

Sex: Male·Age: 18+

Code: NCT05804318·Recruiting

Apply to this trial

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

for Mesothelioma

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05730816·Phase 2·Recruiting

Apply to this trial

Dietary Intervention to Mitigate Adverse Consequences of Night Work

for Dietary Habits

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT04868526·Recruiting

Apply to this trial

The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

for Chronic Kidney Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07222683·Recruiting

Apply to this trial

Shingrix in Renal Transplant Recipients

for Kidney Transplant Recipient Response to Shingrix Vaccine

4 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 70

Code: NCT04128189·Phase 3·Recruiting

Apply to this trial

Patient-Centered Surgical Prehabilitation

for Bladder Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05715684·Recruiting

Apply to this trial

Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

for Peripheral Artery Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06300450·Recruiting

Apply to this trial

VS-6766+Abema+Fulv in Met HR+/HER- BC

for Breast Cancer

3 locations incl. Boston

Sponsor: Adrienne G. Waks

Sex: All·Age: 18+

Code: NCT05608252·Phase 1, Phase 2·Recruiting

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Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

313 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

8 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting

Apply to this trial

Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Three-dimensional (3D) Printed Hemodialysis Vascular Model

for Hemodialysis Access Failure

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05096416·Not Yet Recruiting

Biology of Young Lung Cancer Study: The YOUNG LUNG Study

for Non Small Cell Lung Cancer

4 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15+

Code: NCT05265429·Recruiting

Apply to this trial

Testing Effects of Melatonin on Uterine Contractions in Women

for Pregnant Women

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05358834·Recruiting

Apply to this trial

Investigating Hereditary Risk In Thoracic Cancers (INHERIT)

for Lung Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05587439·Recruiting

Apply to this trial

Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

for Primary Aldosteronism

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 85

Code: NCT05030545·Phase 4·Recruiting

Apply to this trial

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

for Melanoma

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 16+

Code: NCT05538130·Phase 1·Recruiting

Apply to this trial

An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

for Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

46 locations incl. Scottsdale

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05667493·Phase 3·Enrolling By Invitation

Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer

for Ovarian Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18+

Code: NCT04701645·Phase 1·Recruiting

Apply to this trial

Menstrual-phase-dependent Differences in Response to Sleep Loss

for Sleep Deprivation

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05381532·Recruiting

Apply to this trial

PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

for Type2Diabetes

36 locations incl. Huntsville

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 80

Code: NCT05390892·Phase 4·Recruiting

Apply to this trial

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

for Subacute Cutaneous Lupus Erythematosus

61 locations incl. Anniston

Sponsor: Biogen

Sex: All·Age: 18+

Code: NCT05531565·Phase 2, Phase 3·Recruiting

Apply to this trial

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

for Idiopathic Pulmonary Fibrosis

86 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 40+

Code: NCT04905693·Phase 3·Enrolling By Invitation

Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

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Pre-emptive Prevention for Patients at High Risk for Hospital-onset Clostridioides Difficile

for C. Difficile

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05389904·Recruiting

Apply to this trial

Endoscopic Metabolic and Bariatric Therapies

for Obesity

1 location in Boston

Sponsor: Christopher C. Thompson, MD, MSc

Sex: All·Age: 18 - 80

Code: NCT05725967·Enrolling By Invitation