Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Brigham and Women's Hospital
Study ID
NCT06300450
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Computer Alert — BEHAVIORAL
    On-screen alert-based decision support raising awareness of need for lipid-lowering therapy in patients with peripheral artery disease

Study Details

This single-center, 400-patient, randomized controlled trial assesses the impact of a patient- and provider-facing EPIC Best Practice Advisory (BPA; alert-based computerized decision support tool) to increase guideline-directed utilization of statin and statin-alternative oral LDL-C lowering therapies in patients with PAD who are not being prescribed LDL-C-lowering therapy.

Key Dates

Start date
Mar 1, 2023
Status verified
Sep 2025
Primary completion
Feb 28, 2026
Completion
Jul 30, 2026

Study Design

Enrollment
400 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Alert
    Alert-based CDS will consist of an on-screen electronic alert that will notify the clinician that the patient has an indication for LDL-C-lowering therapy but is not prescribed any. The clinician will have the opportunity to proceed to an order template through which appropriate lipid-lowering can be prescribed. The clinician could also elect to learn more about current evidence-based recommendations for LDL-C lowering in the PAD population. Finally, the clinician could elect to proceed without ordering oral LDL-C-lowering therapy or reading evidence-based recommendations for LDL-C lowering but would have to provide a rationale for not doing so.
  • No Intervention: No Alert
    No on-screen notification will be issued to the clinician

Primary Outcome Measure

Frequency of prescription of oral LDL-C-lowering therapy [ Time Frame: 90 days ]

Central Contacts

  • Gregory Piazza
    6177326984
    [email protected]
  • Candrika D Kharaini
    6177326984
    cdkhairani@@bwh.harvard.edu

Locations (1)

FacilityCityStateZIPSite coordinators
Brigham and Women's HospitalBostonMassachusetts02115
Gregory Piazza, MD, MS
[email protected]
617-732-6984
[email protected]
Gregory Piazza, MD, MS (PRINCIPAL_INVESTIGATOR)
Samuel Goldhaber, MD (SUB_INVESTIGATOR)
Ron Blankstein, MD (SUB_INVESTIGATOR)
Jorge Plutzky, MD (SUB_INVESTIGATOR)

Find similar trials in Boston, MA

By condition
Peripheral artery disease
By specialty
CardiologyVascular medicine
By research site
Brigham and Women's Hospital· Boston, MA

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