Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Nationwide Children's Hospital
Study ID
NCT03622359
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • SPECT/CT perfusion imaging — DIAGNOSTIC_TEST
    Subjects will receive a standard clinical dose of a radionuclide for perfusion imaging of the lower extremities before and after revascularization procedures.
  • PET/CT perfusion imaging — DIAGNOSTIC_TEST
    Subjects will receive a standard clinical dose of a radionuclide for perfusion imaging of the lower extremities before and after revascularization procedures.

Study Details

The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging tool for quantifying regional abnormalities in skeletal muscle perfusion and evaluating responses to medical treatment.

Key Dates

Start date
Feb 17, 2017
Status verified
Mar 2025
Primary completion
Aug 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
192 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: SPECT/CT perfusion imaging
    Patients with peripheral artery disease will have already been scheduled for clinically indicated revascularization procedures of the lower extremity and undergo SPECT/CT imaging as part of the research protocol.
  • Experimental: PET/CT perfusion imaging
    Patients with peripheral artery disease will have already been scheduled for clinically indicated revascularization procedures of the lower extremity and undergo PET/CT imaging as part of the research protocol.

Primary Outcome Measure

Lower extremity perfusion [ Time Frame: 1-2 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Nationwide Children's HospitalColumbusOhio43205
Mitchel R Stacy, Ph.D.
[email protected]
614-355-5836

Find similar trials in Columbus, OH

By condition
Peripheral artery disease
By specialty
CardiologyVascular medicine
By research site
Nationwide Children's Hospital· Columbus, OH

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