Clinical Trials at Brigham and Women's Hospital

As of June 2026, 366 paid clinical trials are recruiting at Brigham and Women's Hospital, located at 75 FRANCIS ST, BOSTON, MA 02115-6110, phone (617) 525-7104 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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366 clinical trials at Brigham and Women's Hospital

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Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC

for Head and Neck Squamous Cell Carcinoma (HNSCC)

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07465276·Phase 2·Recruiting

Apply to this trial

Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

for Hypertension

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 65

Code: NCT07238400·Phase 2·Recruiting

Apply to this trial

Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC

for Renal Cell Carcinoma

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07397611·Phase 2·Recruiting

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Finding Links Between Hot flASHes and CardioVascular Disease

for Menopause-related Hot Flashes

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 40 - 65

Code: NCT07077395·Phase 2·Recruiting

Apply to this trial

Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

for Opioid Consumption, Postoperative

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 45+

Code: NCT07427043·Phase 3·Recruiting

Apply to this trial

Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD

for Lung Transplant Failure and Rejection

3 locations incl. Boston

Sponsor: Brian Keller

Sex: All·Age: 7+

Code: NCT07434869·Not Yet Recruiting

Mindfulness Meditation for Insomnia

for Sleep Initiation and Maintenance Disorders

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06972303·Phase 1, Phase 2·Recruiting

Apply to this trial

SARC046: A Phase II Trial of Nab-Sirolimus in Patients With Progressing or Symptomatic Epithelioid Hemangioendothelioma

for Epithelioid Hemangioendothelioma (EHE)

6 locations incl. Stanford

Sponsor: Sarcoma Alliance for Research through Collaboration

Sex: All·Age: 18+

Code: NCT07104331·Phase 2·Recruiting

Apply to this trial

Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy

for Head Neck Cancer

6 locations incl. Boston

Sponsor: University of Virginia

Sex: All·Age: 18 - 85

Code: NCT07405645·Recruiting

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Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms

for Menopausal Women

Drug: Daridorexant

5 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 40 - 62

Code: NCT07136415·Phase 4·Recruiting

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

18 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting

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A Study of Brenipatide in Participants With Opioid Use Disorder

for Opioid Use Disorder

Drug: Brenipatide

38 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07420283·Phase 2·Recruiting

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A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

13 locations incl. Los Angeles

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting

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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

for Carcinoma, Renal Cell

Drug: PF-08634404

101 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227415·Phase 1, Phase 2·Recruiting

Apply to this trial

SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

11 locations incl. Los Angeles

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting

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A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax

for Acute Myeloid Leukaemia (AML)

Drug: Venetoclax

2 locations incl. Boston

Sponsor: Jacqueline Garcia, MD

Sex: All·Age: 18+

Code: NCT07148180·Phase 1, Phase 2·Recruiting

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OsteoPorotic fracTure preventION System (OPTIONS) Research Study

for Osteoporosis

2 locations incl. Baltimore

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06731608·Recruiting

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Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

for Prostate Cancer

1 location in Boston

Sponsor: Shehzad Basaria, M.D.

Sex: Male·Age: 40+

Code: NCT06957691·Phase 2·Recruiting

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Efficacy of Routine Saline Flushing in the Prevention of Nephrostomy Tube Obstructions: A Pilot Study

for Nephrostomy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 80

Code: NCT06987877·Recruiting

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Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

for Seizures

1 location in Boston

Sponsor: Ayal A. Aizer, MD

Sex: All·Age: 18+

Code: NCT07130786·Phase 2·Recruiting

Apply to this trial

Targeted Accelerated TMS for Post-Traumatic Stress Disorder

for Post Traumatic Stress Disorder (PTSD)

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT07245641·Recruiting

Apply to this trial

A Study of Sasanlimab, Palbociclib and Axitinib in Metastatic Renal Cell Carcinoma

for Metastatic Renal Cell Carcinoma

2 locations incl. Boston

Sponsor: Stephanie Berg

Sex: All·Age: 18+

Code: NCT07123090·Phase 2·Recruiting

Apply to this trial

Zymfentra (Infliximab-dyyb) REal World Cohort STudy

for Ulcerative Colitis (UC)

9 locations incl. New Haven

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07237516·Recruiting

Apply to this trial

Endovascular Repair With Fenestrated TREO Stent-Graft System in AAA

for Abdominal Aortic Aneurysms (AAA)

7 locations incl. Colorado Springs

Sponsor: Bolton Medical

Sex: All·Age: 18+

Code: NCT07026877·Recruiting

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LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

for Ulcerative Colitis

Drug: LY4268989

41 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07186101·Phase 2·Recruiting

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REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study

for Disorders of Consciousness

1 location in Boston

Sponsor: Samuel Snider, MD

Sex: All·Age: 18 - 55

Code: NCT07228286·EARLY_Phase 1·Recruiting

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Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial

for Critical Illness

1 location in Boston

Sponsor: Wandercraft

Sex: All·Age: 18+

Code: NCT07220733·Phase 1, Phase 2·Recruiting

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A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

for Eosinophilic Esophagitis

41 locations incl. Little Rock

Sponsor: Phathom Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06851559·Phase 2·Recruiting

Apply to this trial

Extended-release Buprenorphine as a Novel Low-dose Induction Strategy

for Opioid Use Disorder

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06441604·Phase 2·Recruiting

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Microbial Cell-free Metagenomic Sequencing for Suspected Infections in Adult Immunocompromised Outpatients

for Infection

6 locations incl. San Francisco

Sponsor: Karius, Inc.

Sex: All·Age: 18+

Code: NCT07110636·Recruiting

Apply to this trial

A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

for Asthma

Drug: Brenipatide

17 locations incl. Tempe

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07219173·Phase 2·Recruiting

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A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy

for Vasectomy

1 location in Boston

Sponsor: Alexandra J. Berger Eberhardt, MD

Sex: Male·Age: 18 - 85

Code: NCT07245628·EARLY_Phase 1·Recruiting

Apply to this trial

Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

for Preeclampsia

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07041281·Phase 2·Recruiting

Apply to this trial

Open Label Treprostinil Raynaud's Study

for Raynaud's Disease

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07112183·Phase 4·Recruiting

Apply to this trial

Improving Lipid Optimization Quality and Treatment Options in ASCVD

for Hypercholesterolemia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 95

Code: NCT06960655·Enrolling By Invitation

DT2216 + Paclitaxel in Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

3 locations incl. Boston

Sponsor: Elizabeth Stover, MD, PhD

Sex: Female·Age: 18+

Code: NCT06964009·Phase 1·Recruiting

Apply to this trial

US Benchmarking Clinical Study

for HFpEF - Heart Failure With Preserved Ejection Fraction

3 locations incl. Boston

Sponsor: eMyosound SAS

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07215715·Recruiting

Apply to this trial

Study of Tirzepatide for Recovery and Alcohol Use Management

for Alcohol Use Disorder (AUD)

Drug: Tirzepatide

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06727331·Phase 2·Recruiting

Apply to this trial

A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

for Interstitial Lung Diseases

Drug: Nerandomilast

33 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06806592·Phase 3·Recruiting

Apply to this trial

Feasibility Study Evaluating the Safety and Effectiveness of Magnetic Bead Tracking System When Used With a Bionic External Prosthesis

for Transtibial Amputee

1 location in Boston

Sponsor: MuscleMetrix, LLC

Sex: All·Age: 22 - 65

Code: NCT07195461·EARLY_Phase 1·Recruiting

Apply to this trial