Psychiatry Clinical Trials in Boston, MA

As of June 2026, 106 paid clinical trials are recruiting for Psychiatry in Boston, Massachusetts. Psychiatry trials evaluate new antidepressants, psychedelic-assisted therapies, novel antipsychotics, ADHD treatments, and digital therapeutics across depression, anxiety, PTSD, and schizophrenia. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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106 clinical trials for Psychiatry

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NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

10 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06911112·Phase 3·Recruiting

Apply to this trial

Project EMPOWER-OCD

for Obsessive-Compulsive Disorder

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07158801·Recruiting

Apply to this trial

An Open-Label Study of Azetukalner in Major Depressive Disorder

for Major Depressive Disorder

63 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06922110·Phase 3·Enrolling By Invitation

Suicide Risk Interventions

for Suicide

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05931289·Phase 2·Recruiting

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Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors

for Suicide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05671133·Recruiting

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Cannabis, Linked Emotions, and Adolescent Risk Study

for Cannabis Use

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 18

Code: NCT06576076·Recruiting

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Evaluation of a Trauma-Informed Partner Violence Intervention Program

for Domestic Violence

2 locations incl. Boston

Sponsor: Boston University

Sex: Male·Age: 18+

Code: NCT06803043·Enrolling By Invitation

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

for Major Depressive Disorder

34 locations incl. Birmingham

Sponsor: Syndeio Biosciences, Inc

Sex: All·Age: 18 - 64

Code: NCT06547489·Phase 2·Recruiting

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Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting

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Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

for Major Depressive Disorder

2 locations incl. Sunnyvale

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06376734·Phase 2·Recruiting

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Diabetes Body Project 2

for Eating Disorders

1 location in Boston

Sponsor: Joslin Diabetes Center

Sex: Female·Age: 18 - 40

Code: NCT07468188·Recruiting

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Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

18 locations incl. Little Rock

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06786624·Phase 3·Recruiting

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Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

for Stress Disorders, Post-Traumatic

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT06088303·Recruiting

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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

for Major Depressive Disorder

46 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT06775379·Phase 3·Recruiting

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"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

for Major Depressive Disorder

46 locations incl. Phoenix

Sponsor: Cybin IRL Limited

Sex: All·Age: 18 - 85

Code: NCT06564818·Phase 3·Recruiting

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Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

30 locations incl. Birmingham

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18+

Code: NCT06701903·Phase 2·Recruiting

Apply to this trial

Just-in-time Interventions for Reducing Short-term Suicide Risk

for Suicide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05793541·Recruiting

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Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

for Major Depressive Disorder

50 locations incl. Birmingham

Sponsor: Autobahn Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06633016·Phase 2·Recruiting

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

34 locations incl. Chandler

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18+

Code: NCT06480383·Phase 2·Recruiting

Apply to this trial

Connectomic Targeted TMS Target for Refractory Anxiety

for Anxiety Disorders

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT06376877·Phase 2·Not Yet Recruiting

Cerebellar Modulation of Cognition in Psychosis

for Schizophrenia

2 locations incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 55

Code: NCT06107764·Recruiting

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A Multicenter Pediatric Deep Brain Stimulation Registry

for Dystonia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 18

Code: NCT06585618·Recruiting

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Study on Allopregnanolone and Depression in Women Across the Menopause Transition

for Depression

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: Female·Age: 40 - 60

Code: NCT06238700·Recruiting

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Evaluation of a Twenty-session Cognitive-behavioral Therapy With Anorexia Nervosa (CBT-20-AN) Among Adults (18+)

for Anorexia Nervosa

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06597305·Enrolling By Invitation

Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

for Anxiety Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 19

Code: NCT05962879·Recruiting

Apply to this trial

Expressive Writing on Minority Stressors Among Sexual Minority Veterans

for Depressive Symptoms

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05897021·Recruiting

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Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05523817·Recruiting

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A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans

for TBI

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05995678·Recruiting

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Enhanced Coordinated Specialty Care for Early Psychosis

for Psychosis

5 locations incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: All ages

Code: NCT06071858·Recruiting

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Mechanisms Underlying the Efficacy of Prolonged Exposure

for Posttraumatic Stress Disorder

1 location in Boston

Sponsor: VA Boston Healthcare System

Sex: All·Age: 18 - 90

Code: NCT05663151·Recruiting

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A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

for Major Depressive Disorder

40 locations incl. Bellflower

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06223880·Phase 4·Recruiting

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Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

for Major Depressive Episode

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT04130958·Recruiting

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Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer

for Stress

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 12 - 25·Accepts healthy volunteers

Code: NCT06038318·Recruiting

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AWARE: Management of ADHD in Autism Spectrum Disorder

for ADHD

10 locations incl. Irvine

Sponsor: Daniel Coury

Sex: All·Age: 4 - 17

Code: NCT05916339·Phase 4·Recruiting

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Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

for Posttraumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT06429293·Recruiting

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Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II

for Depression

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT05555875·Recruiting

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Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

for Major Depressive Disorder

3 locations incl. Boston

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 65

Code: NCT05573074·Recruiting

Apply to this trial

Mechanisms Underlying Efficacy of Prolonged Exposure

for Post Traumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05788302·Recruiting

Apply to this trial

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05570812·Phase 2·Recruiting

Apply to this trial

Conditions in Psychiatry (Boston, MA)

Depression· 55 Anxiety· 20 PTSD (post-traumatic stress disorder)· 16 Schizophrenia· 13 Suicidal ideation / suicide· 10 Obsessive-compulsive disorder (OCD)· 5 ADHD· 4 Bipolar disorder· 3 Eating disorders· 2 Mood disorders· 1