Oncology Clinical Trials in Boston, MA

As of June 2026, 704 paid clinical trials are recruiting for Oncology in Boston, Massachusetts. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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704 clinical trials for Oncology

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Increasing Resiliency Among Early Post-Treatment Lymphoma Survivors

for Lymphoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07014293·Not Yet Recruiting

ELDORADO: Elranatamab Versus Daratumumab in Combination With RVd Lite for Newly Diagnosed Transplant Ineligible/Deferred Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07247097·Phase 2·Not Yet Recruiting

Remote Monitoring and Symptom Management Digital Application

for Breast Cancer (Locally Advanced or Metastatic)

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT07553572·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

for Ewing Sarcoma

4 locations incl. Los Angeles

Sponsor: Amgen

Sex: All·Age: 2+

Code: NCT07297979·Phase 1·Recruiting

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Wearable Ultrasound Patch for Breast Imaging

for Breast Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07186491·Not Yet Recruiting

GDF-15 and Its Relationship With Treatment-related ADverse Events in Breast Cancer

for Breast Cancer

1 location in Boston

Sponsor: Breast Cancer Trials, Australia and New Zealand

Sex: All·Age: 18+

Code: NCT07465172·Not Yet Recruiting

Study in Advanced Solid Tumor Patients

for Advanced Solid Tumor

5 locations incl. Boston

Sponsor: Callio Therapeutics

Sex: All·Age: 18+

Code: NCT07300943·Phase 1, Phase 2·Recruiting

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A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

for Non-small Cell Lung Cancer (NSCLC)

Drug: Durvalumab

38 locations incl. Daphne

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07361497·Phase 3·Recruiting

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On-Trac: An Online Intervention for Cancer Survivors Managing Anxiety

for Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07305740·Recruiting

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PDT For Induction Therapy For Head And Neck Cancer

for Squamous Cell Carcinoma

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07214987·Phase 2·Not Yet Recruiting

Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC

for Renal Cell Carcinoma

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07397611·Phase 2·Recruiting

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Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for Pancreatic Cancer

Drug: daraxonrasib

5 locations incl. Baltimore

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT07491445·Phase 3·Recruiting

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Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

for Opioid Consumption, Postoperative

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 45+

Code: NCT07427043·Phase 3·Recruiting

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Oncoplastic Surgery Outcomes Database

for Breast Cancer

2 locations incl. Boston

Sponsor: Tufts Medical Center

Sex: Female·Age: 18+

Code: NCT07597837·Recruiting

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Momelotinib During and After HCT in Myelofibrosis

for Myelofibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07104799·Phase 1·Recruiting

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Adoptive T Cell Therapy With DC/AML Fusion Vaccine Plus Decitabine and Venetoclax in AML

for Acute Myeloid Leukemia

Drug: Venetoclax

1 location in Boston

Sponsor: David Avigan

Sex: All·Age: All ages

Code: NCT07374029·Phase 1·Recruiting

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Rituximab Plus Venetoclax in Front Line Marginal Zone Lymphoma

for Lymphoma

Drug: Venetoclax

1 location in Boston

Sponsor: Gottfried von Keudell, MD PhD

Sex: All·Age: 18+

Code: NCT06510309·Phase 2·Recruiting

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Distance-Based Exercise to Preserve Function and Prevent Disability

for Hematopoietic and Lymphatic System Neoplasm

17 locations incl. Dublin

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884·Recruiting

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Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

for Solid Tumor

Drug: Givastomig

3 locations incl. Goodyear

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT07432295·Phase 2·Recruiting

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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

for Carcinoma, Renal Cell

Drug: PF-08634404

101 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227415·Phase 1, Phase 2·Recruiting

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TIL Therapy in cSCC and MCC

for Cutaneous Squamous Cell Carcinoma

1 location in Boston

Sponsor: Karam Khaddour, MD, MS

Sex: All·Age: 18+

Code: NCT07288073·Phase 2·Recruiting

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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

29 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07266441·Phase 2·Recruiting

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A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

for Advanced Solid Tumor

6 locations incl. Boston

Sponsor: Ipsen

Sex: All·Age: 18+

Code: NCT07213830·Phase 1, Phase 2·Recruiting

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SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

11 locations incl. Los Angeles

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

77 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting

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A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax

for Acute Myeloid Leukaemia (AML)

Drug: Venetoclax

2 locations incl. Boston

Sponsor: Jacqueline Garcia, MD

Sex: All·Age: 18+

Code: NCT07148180·Phase 1, Phase 2·Recruiting

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DC/MM Fusion Vaccine With BCMA CAR-T in R/R MM

for Multiple Myeloma

1 location in Boston

Sponsor: David Avigan

Sex: All·Age: 18+

Code: NCT07377435·Phase 1·Recruiting

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Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

for Glioblastoma

9 locations incl. Boston

Sponsor: Alpheus Medical, Inc.

Sex: All·Age: 18 - 80

Code: NCT07225621·Phase 2·Recruiting

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A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs

for Prostate Cancer

8 locations incl. Duarte

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT07336446·Phase 1, Phase 2·Recruiting

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A Study of Isoquercetin in People With Ovarian Cancer

for Ovarian Cancer

8 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07303894·Phase 2·Recruiting

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Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

for Non-small Cell Lung Cancer

29 locations incl. Fresno

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07195695·Phase 3·Recruiting

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PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

for Estrogen-receptor-positive Breast Cancer

1 location in Boston

Sponsor: Kristina A. Fanucci

Sex: All·Age: 18+

Code: NCT07222215·Phase 2·Recruiting

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A First-in-Human Study of BMS-986506 in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

for Renal Cell Carcinoma

Drug: BMS-986506

5 locations incl. Boston

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07195682·Phase 1·Recruiting

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Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

for Prostate Cancer

1 location in Boston

Sponsor: Shehzad Basaria, M.D.

Sex: Male·Age: 40+

Code: NCT06957691·Phase 2·Recruiting

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SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study

for Colorectal Cancer

12 locations incl. Los Angeles

Sponsor: SafeHeal Inc

Sex: All·Age: 22+

Code: NCT07116668·Enrolling By Invitation

Feasibility and Acceptability of Primary Palliative Care Intervention in Patients Undergoing Hematopoietic Stem Cell Transplantation

for Hematopoietic Cell Transplant

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06676852·Recruiting

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A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

for Breast Neoplasms

117 locations incl. Anchorage

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07174336·Phase 3·Recruiting

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A Study of [18F]LY4214835 in Healthy Volunteers and Participants With Cancer

for Neoplasms

6 locations incl. New Haven

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07258836·Phase 1·Recruiting

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A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients With Advanced Solid Tumors

for Advanced Solid Tumors

4 locations incl. Boston

Sponsor: Ottimo Pharma Limited

Sex: All·Age: 18+

Code: NCT07266428·Phase 1, Phase 2·Recruiting

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Conditions in Oncology (Boston, MA)

Solid tumor· 120 Breast cancer· 81 Non-small cell lung cancer (NSCLC)· 73 Prostate cancer· 48 Cancer (any)· 47 Colorectal cancer· 40 Ovarian cancer· 38 Acute myeloid leukemia (AML)· 36 Metastatic breast cancer· 34 Pancreatic cancer· 34 Multiple myeloma· 34 Non-Hodgkin lymphoma· 33 Endometrial cancer· 31 Lung cancer· 28 Head and neck cancer· 26 Gastric cancer· 24 Myelodysplastic syndromes (MDS)· 24 Glioblastoma· 22 Chronic lymphocytic leukemia (CLL)· 21 Leukemia (other)· 21 Esophageal cancer· 20 Hematologic malignancy· 19 Triple-negative breast cancer· 18 Bladder cancer· 16 Melanoma· 14 Metastatic prostate cancer· 13 Kidney cancer· 13 Neuroblastoma· 13 Biliary tract cancer· 12 Glioma· 12 Follicular lymphoma· 12 Small lymphocytic lymphoma· 12 HER2-negative breast cancer· 10 Small cell lung cancer· 10 Diffuse large B-cell lymphoma (DLBCL)· 10 Skin cancer· 10 Gastroesophageal junction cancer· 9 Cervical cancer· 9 Fallopian tube cancer· 9 Brain cancer· 9 Myelofibrosis· 9 Mantle cell lymphoma· 9 HER2-positive breast cancer· 8 Thyroid cancer· 8 Liver cancer· 7 Myeloproliferative neoplasm· 7 Mesothelioma· 7 Metastatic colorectal cancer· 6 Rectal cancer· 6 Acute lymphoblastic leukemia· 6 Hodgkin lymphoma· 6 Sarcoma· 6 Pediatric cancer· 6 Colon cancer· 5 Marginal zone lymphoma· 5 Osteosarcoma· 5 Ewing sarcoma· 5 Gastrointestinal cancer· 4 Brain metastases· 4 Chronic myelomonocytic leukemia· 4 Uterine cancer· 3 Gynecologic cancer· 3 Rhabdomyosarcoma· 3 Burkitt lymphoma· 2 Soft tissue sarcoma· 2 Neuroendocrine tumors· 2