A Study of Isoquercetin in People With Ovarian Cancer

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07303894
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Isoquercetin — DRUG
    Cohort B and Cohort C will take isoquercetin
  • Placebo — OTHER
    Placebo

Study Details

The purpose of this study is to test whether isoquercetin can reduce markers in the blood that may indicate the risk of blood clots in people with ovarian cancer. The effects of isoquercetin will be compared with those of a placebo.

Key Dates

Start date
Jan 22, 2026
Status verified
Apr 2026
Primary completion
Jan 31, 2032
Completion
Jan 31, 2032

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Cohort A: Placebo
  • Experimental: Cohort B: Isoquercetin daily
  • Experimental: Cohort C: Isoquercetin twice daily

Primary Outcome Measure

Level of PDI-sensitive, platelet-dependent thrombin generation measured as compared to baseline [ Time Frame: up to 6 weeks from baseline ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
Beth Israel Deaconess Medical Center (Data Collection Only)BostonMassachusetts02215
Robert Flaumenhaft, MD, PhD
617-735-4005
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)Basking RidgeNew Jersey07920
Jeffrey A Zwicker, MD
646-608-3723
Memorial Sloan Kettering Monmouth (All Protocol Activities)MiddletownNew Jersey07748
Jeffrey Zwicker, MD
646-608-3723
Memorial Sloan Kettering Bergen (All Protocol Activities)MontvaleNew Jersey07645
Jeffrey Zwicker, MD
646-608-3723
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities )CommackNew York11725
Jeffrey Zwicker, MD
646-608-3723
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604
Jeffrey Zwicker, MD
646-608-3723
Memorial Sloan Kettering Cancer Center (All Protocol Activites)New YorkNew York10065
Jeffrey Zwicker, MD
646-608-3723
Memorial Sloan Kettering Nassau (All protocol activities)Rockville CentreNew York11553
Jeffrey Zwicker, MD
646-608-3723

Find similar trials in Boston, MA

By condition
Ovarian cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Beth Israel Deaconess Medical Center (Data Collection Only)· Boston, MAMemorial Sloan Kettering Basking Ridge (All Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (All Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk-Commack (All Protocol Activities )· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NY

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