Valacyclovir Evidence: Trial Results and Peer-Reviewed Publications

Hipa.ai Research · Source: PubMed & ClinicalTrials.gov / AACT · Last updated:

The clinical evidence base for Valacyclovir comprises 114 peer-reviewed publications across 15 journals, 2 pivotal-trial primary-outcome rows reported to ClinicalTrials.gov, spanning indications including Herpes Simplex, Cytomegalovirus Infections, Prostatic Neoplasms, and Herpes Genitalis. Most recent publication: A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma., Neuro Oncol, 2026.

Top peer-reviewed publications

Curated set of pivotal-trial result papers and recent publications in high-tier journals.

  1. Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
    Wheeler LA, Manzanera AG, Bell SD, et al. · Neuro Oncol · 2017
    PubMed: PMID 26843484 · NCT00589875 (BrTK02) · Glioblastoma
  2. Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
    Predina JD, Haas AR, Martinez M, et al. · Mol Ther · 2021
    PubMed: PMID 33160076 · NCT03131037 · Lung Neoplasms
  3. In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study.
    Leruez-Ville M, Ghout I, Bussières L, et al. · Am J Obstet Gynecol · 2017
    PubMed: PMID 27083761 · NCT01651585 (CYMEVAL2) · Cytomegalovirus Infections
  4. Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma.
    Kieran MW, Goumnerova L, Manley P, et al. · Neuro Oncol · 2020
    PubMed: PMID 30883662 · NCT00634231 · Glioblastoma
  5. Cytokine Profiling of Amniotic Fluid from Congenital Cytomegalovirus Infection.
    Bourgon N, Fitzgerald W, Aschard H, et al. · Viruses · 2022
    PubMed: PMID 36298700 · NCT01651585 (CYMEVAL2) · Cytomegalovirus Infections
  6. In vivo and in vitro palatability testing of a new paediatric formulation of valaciclovir.
    Bastiaans DET, Immohr LI, Zeinstra GG, et al. · Br J Clin Pharmacol · 2018
    PubMed: PMID 28800385 · NCT01682109 (VALID-0) · Herpes Simplex
  7. A new paediatric formulation of valaciclovir: development and bioequivalence assessment.
    Bastiaans DE, Bartels-Wilmer CM, Colbers AP, et al. · Arch Dis Child · 2018
    PubMed: PMID 27162003 · NCT01689285 (VALID-I) · Herpes Simplex
  8. Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion.
    Aggarwal C, Haas AR, Metzger S, et al. · Mol Ther · 2019
    PubMed: PMID 29550074 · NCT01997190 (MpeTK01) · Lung Neoplasms

Primary-outcome results across pivotal trials

Per-arm reported values from Phase 2/3 and Phase 3 trials with results posted to ClinicalTrials.gov.

TrialIndicationPrimary endpointArmValue
NCT00031486Herpes SimplexSurvival With no or Mild Neuropsychological Impairment at 12 Months After Initiation of Study Medication as Measured by the Mattis Dementia Rating Scale (MDRS)
One year post therapy.
Placebo2 Participants
Placebo34 Participants
Total7 Participants
Total62 Participants
Valacyclovir28 Participants
Valacyclovir5 Participants
NCT00306787Herpes SimplexInvestigator-assessed Time to Healing of All Non-aborted Genital Herpes Lesions
72 hours after initiation of study medication up to Day 20
Famciclovir4.25 days
Valacyclovir4.08 days

Publications by year

1968–2026: 114 publications.

1968
1
1970
1
1988
1
1995
2
1996
1
1997
4
1998
4
1999
7
2000
2
2002
3
2003
2
2004
6
2005
5
2006
8
2007
8
2008
6
2009
6
2010
1
2011
5
2012
8
2013
2
2014
4
2015
2
2016
1
2017
4
2018
3
2019
1
2020
4
2021
2
2022
2
2024
2
2025
4
2026
2

Publications by indication

Herpes Simplex (48)

  • In vivo and in vitro palatability testing of a new paediatric formulation of valaciclovir.
    Br J Clin Pharmacol · 2018 · PMID 28800385 · NCT01682109
  • A new paediatric formulation of valaciclovir: development and bioequivalence assessment.
    Arch Dis Child · 2018 · PMID 27162003 · NCT01689285
  • Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy.
    Clin Infect Dis · 2016 · PMID 25956891 · NCT00031486
  • A randomized controlled pilot trial of valacyclovir for attenuating inflammation and immune activation in HIV/herpes simplex virus 2-coinfected adults on suppressive antiretroviral therapy.
    Clin Infect Dis · 2014 · PMID 23946220 · NCT01176409
  • Maternal valacyclovir and infant cytomegalovirus acquisition: a randomized controlled trial among HIV-infected women.
    PLoS One · 2014 · PMID 24504006 · NCT00530777

Cytomegalovirus Infections (14)

  • Valacyclovir for the prevention of cytomegalovirus infection after kidney transplantation.
    BMC Infect Dis · 2025 · PMID 40045190 · NCT07294547
  • Valacyclovir versus valganciclovir for cytomegalovirus prophylaxis in kidney transplant recipients: a systematic review and comparative meta-analysis.
    Clin Transplant Res · 2025 · PMID 39510821 · NCT07294547
  • Cytokine Profiling of Amniotic Fluid from Congenital Cytomegalovirus Infection.
    Viruses · 2022 · PMID 36298700 · NCT01651585
  • Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial.
    Lancet · 2020 · PMID 32919517 · NCT02351102
  • Sequelae of Congenital Cytomegalovirus Following Maternal Primary Infections Are Limited to Those Acquired in the First Trimester of Pregnancy.
    Clin Infect Dis · 2020 · PMID 30596974 · NCT01651585

Prostatic Neoplasms (12)

  • Immunogenic cell death in cancer therapy.
    Annu Rev Immunol · 2013 · PMID 23157435 · NCT03541928
  • The convergence of radiation and immunogenic cell death signaling pathways.
    Front Oncol · 2012 · PMID 22891162 · NCT03541928
  • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
    Int J Cancer · 2011 · PMID 21351269 · NCT03541928
  • Dose escalation and quality of life in patients with localized prostate cancer treated with radiotherapy: long-term results of the Dutch randomized dose-escalation trial (CKTO 96-10 trial).
    Int J Radiat Oncol Biol Phys · 2011 · PMID 20421153 · NCT03541928
  • Final report of multicenter Canadian Phase III randomized trial of 3 versus 8 months of neoadjuvant androgen deprivation therapy before conventional-dose radiotherapy for clinically localized prostate cancer.
    Int J Radiat Oncol Biol Phys · 2009 · PMID 18707821 · NCT03541928

Herpes Genitalis (8)

  • Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
    JAMA · 2017 · PMID 27997653 · NCT01658826
  • Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials.
    Lancet · 2012 · PMID 22225814 · NCT00362297
  • ASP2151 for the treatment of genital herpes: a randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study.
    J Infect Dis · 2012 · PMID 22351940 · NCT00486200
  • Can herpes simplex virus type 2 suppression slow HIV disease progression: a study protocol for the VALacyclovir In Delaying Antiretroviral Treatment Entry (VALIDATE) trial.
    Trials · 2011 · PMID 21106086 · NCT00860977
  • Roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (HIV-1)-induced immunosuppression on genital and plasma HIV-1 levels.
    J Infect Dis · 2008 · PMID 18593294 · NCT00158509

Herpes Zoster (7)

  • Low-Dose Valacyclovir for Postherpetic Neuralgia in the Zoster Eye Disease Study: A Randomized Clinical Trial.
    JAMA Ophthalmol · 2025 · PMID 40048191 · NCT03134196
  • Low-Dose Valacyclovir in Herpes Zoster Ophthalmicus: The Zoster Eye Disease Randomized Clinical Trial.
    JAMA Ophthalmol · 2025 · PMID 40048183 · NCT03134196
  • Baseline Participant Characteristics at Enrollment in the Zoster Eye Disease Study.
    Cornea · 2024 · PMID 38411973 · NCT03134196
  • Zoster Eye Disease Study: Rationale and Design.
    Cornea · 2022 · PMID 35090154 · NCT03134196
  • FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.
    J Med Virol · 2018 · PMID 27943311 · NCT00900783

HIV Infections (5)

  • Valacyclovir therapy does not reverse herpes-associated alterations in cervical immunology: a randomized, placebo-controlled crossover trial.
    J Infect Dis · 2014 · PMID 24664172 · NCT00946556
  • Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract.
    AIDS · 2007 · PMID 17314521 · NCT00946556
  • Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection: relationship to CMV disease.
    J Infect Dis · 2002 · PMID 12085316 · NCT00001038
  • A randomized, double-blind trial of valaciclovir prophylaxis for cytomegalovirus disease in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group.
    J Infect Dis · 1998 · PMID 9419169 · NCT00001038
  • Manifestations resembling thrombotic microangiopathy in patients with advanced human immunodeficiency virus (HIV) disease in a cytomegalovirus prophylaxis trial (ACTG 204).
    Medicine (Baltimore) · 1997 · PMID 9352739 · NCT00001038

Publications by journal

Trial-results highlights

Valacyclovir has been evaluated in clinical trials for its use in treating herpes simplex. One pivotal study, NCT00031486, investigated the drug's effect on herpes simplex and reported on the endpoint of survival with no or mild neuropsychological impairment. This outcome was assessed at 12 months after the start of study medication, using the Mattis Dementia Rating Scale (MDRS). In this trial, the placebo arm reported **2 participants** and **34 participants** for this specific endpoint. The valacyclovir arm reported **28 participants** and **5 participants**. Across the entire study population, **7 participants** and **62 participants** were reported for this measure.

Another key study, NCT00306787, also examined Valacyclovir in individuals with herpes simplex. The primary outcome in this trial was the investigator-assessed time to healing of all non-aborted genital herpes lesions, measured from 72 hours after initiation of study medication up to Day 20. In the valacyclovir arm, the median time to healing was **4.08 days**. For comparison, the famciclovir arm in the same study reported a median time to healing of **4.25 days**.

All values presented here are derived from primary registry reporting. For clinical decisions, individual study papers should be consulted.

All Valacyclovir publications (114)

2026 (2 papers)

  1. A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma.
    Wen PY, Manzanera A, Duault C, et al. · Neuro Oncol · 2026 · Derived
    PubMed: PMID 40120123 · NCT03576612 (GMCI) · Glioblastoma
  2. Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial.
    Devanand DP, Wisniewski T, Razlighi Q, et al. · JAMA · 2026 · Derived
    PubMed: PMID 41405855 · NCT03282916 · Alzheimer Disease

2025 (4 papers)

  1. Low-Dose Valacyclovir for Postherpetic Neuralgia in the Zoster Eye Disease Study: A Randomized Clinical Trial.
    Warner DB, Jeng BH, Kim J, et al. · JAMA Ophthalmol · 2025 · Derived
    PubMed: PMID 40048191 · NCT03134196 (ZEDS) · Herpes Zoster
  2. Low-Dose Valacyclovir in Herpes Zoster Ophthalmicus: The Zoster Eye Disease Randomized Clinical Trial.
    Cohen EJ, Troxel AB, Liu M, et al. · JAMA Ophthalmol · 2025 · Derived
    PubMed: PMID 40048183 · NCT03134196 (ZEDS) · Herpes Zoster
  3. Valacyclovir for the prevention of cytomegalovirus infection after kidney transplantation.
    Kim JS, Lee NR, Park KI, et al. · BMC Infect Dis · 2025 · Background
    PubMed: PMID 40045190 · NCT07294547 · Cytomegalovirus Infections
  4. Valacyclovir versus valganciclovir for cytomegalovirus prophylaxis in kidney transplant recipients: a systematic review and comparative meta-analysis.
    Cardoso LJC, Martins KAM, Marques PV, et al. · Clin Transplant Res · 2025 · Background
    PubMed: PMID 39510821 · NCT07294547 · Cytomegalovirus Infections

2024 (2 papers)

  1. Baseline Participant Characteristics at Enrollment in the Zoster Eye Disease Study.
    Prescott CR, Cohen EJ, Hochman JS, et al. · Cornea · 2024 · Derived
    PubMed: PMID 38411973 · NCT03134196 (ZEDS) · Herpes Zoster
  2. Urinary Viral Spectrum in Patients with Interstitial Cystitis/Bladder Pain Syndrome and the Clinical Efficacy of Valacyclovir Treatment.
    Kuo HC, Peng CW, Jiang YH, et al. · Biomedicines · 2024 · Derived
    PubMed: PMID 38540138 · NCT05094414 (VARIC) · Chronic Pain

2022 (2 papers)

  1. Cytokine Profiling of Amniotic Fluid from Congenital Cytomegalovirus Infection.
    Bourgon N, Fitzgerald W, Aschard H, et al. · Viruses · 2022 · Trial result
    PubMed: PMID 36298700 · NCT01651585 (CYMEVAL2) · Cytomegalovirus Infections
  2. Zoster Eye Disease Study: Rationale and Design.
    Cohen EJ, Hochman JS, Troxel AB, et al. · Cornea · 2022 · Derived
    PubMed: PMID 35090154 · NCT03134196 (ZEDS) · Herpes Zoster

2021 (2 papers)

  1. Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
    Predina JD, Haas AR, Martinez M, et al. · Mol Ther · 2021 · Trial result
    PubMed: PMID 33160076 · NCT03131037 · Lung Neoplasms
  2. Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial.
    Devanand DP, Andrews H, Kreisl WC, et al. · BMJ Open · 2021 · Derived
    PubMed: PMID 32034019 · NCT03282916 · Alzheimer Disease

2020 (4 papers)

  1. Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma.
    Kieran MW, Goumnerova L, Manley P, et al. · Neuro Oncol · 2020 · Trial result
    PubMed: PMID 30883662 · NCT00634231 · Glioblastoma
  2. Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial.
    Shahar-Nissan K, Pardo J, Peled O, et al. · Lancet · 2020 · Derived
    PubMed: PMID 32919517 · NCT02351102 · Cytomegalovirus Infections
  3. Sequelae of Congenital Cytomegalovirus Following Maternal Primary Infections Are Limited to Those Acquired in the First Trimester of Pregnancy.
    Faure-Bardon V, Magny JF, Parodi M, et al. · Clin Infect Dis · 2020 · Derived
    PubMed: PMID 30596974 · NCT01651585 (CYMEVAL2) · Cytomegalovirus Infections
  4. Herpes simplex virus 1 infection and valacyclovir treatment in schizophrenia: Results from the VISTA study.
    Breier A, Buchanan RW, D'Souza D, et al. · Schizophr Res · 2020 · Derived
    PubMed: PMID 30478008 · NCT02008773 (VISTA) · Psychotic Disorders

2019 (1 paper)

  1. Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion.
    Aggarwal C, Haas AR, Metzger S, et al. · Mol Ther · 2019 · Trial result
    PubMed: PMID 29550074 · NCT01997190 (MpeTK01) · Lung Neoplasms

2018 (3 papers)

  1. In vivo and in vitro palatability testing of a new paediatric formulation of valaciclovir.
    Bastiaans DET, Immohr LI, Zeinstra GG, et al. · Br J Clin Pharmacol · 2018 · Trial result
    PubMed: PMID 28800385 · NCT01682109 (VALID-0) · Herpes Simplex
  2. A new paediatric formulation of valaciclovir: development and bioequivalence assessment.
    Bastiaans DE, Bartels-Wilmer CM, Colbers AP, et al. · Arch Dis Child · 2018 · Trial result
    PubMed: PMID 27162003 · NCT01689285 (VALID-I) · Herpes Simplex
  3. FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.
    Tyring SK, Lee P, Hill GT, et al. · J Med Virol · 2018 · Derived
    PubMed: PMID 27943311 · NCT00900783 · Herpes Zoster

2017 (4 papers)

  1. Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
    Wheeler LA, Manzanera AG, Bell SD, et al. · Neuro Oncol · 2017 · Trial result
    PubMed: PMID 26843484 · NCT00589875 (BrTK02) · Glioblastoma
  2. In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study.
    Leruez-Ville M, Ghout I, Bussières L, et al. · Am J Obstet Gynecol · 2017 · Trial result
    PubMed: PMID 27083761 · NCT01651585 (CYMEVAL2) · Cytomegalovirus Infections
  3. Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
    Wald A, Timmler B, Magaret A, et al. · JAMA · 2017 · Derived
    PubMed: PMID 27997653 · NCT01658826 · Herpes Genitalis
  4. Valganciclovir versus valacyclovir prophylaxis for prevention of cytomegalovirus: an economic perspective.
    Kacer M, Kielberger L, Bouda M, et al. · Transpl Infect Dis · 2017 · Background
    PubMed: PMID 25824586 · NCT01972035 · Cytomegalovirus Infections

2016 (1 paper)

  1. Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy.
    Gnann JW, Sköldenberg B, Hart J, et al. · Clin Infect Dis · 2016 · Derived
    PubMed: PMID 25956891 · NCT00031486 · Herpes Simplex

2015 (2 papers)

  1. Gene-mediated cytotoxic immunotherapy as adjuvant to surgery or chemoradiation for pancreatic adenocarcinoma.
    Aguilar LK, Shirley LA, Chung VM, et al. · Cancer Immunol Immunother · 2015 · Trial result
    PubMed: PMID 25795132 · NCT00638612 (PaTK01) · Pancreatic Neoplasms
  2. Randomized trial of valganciclovir versus valacyclovir prophylaxis for prevention of cytomegalovirus in renal transplantation.
    Reischig T, Kacer M, Jindra P, et al. · Clin J Am Soc Nephrol · 2015 · Background
    PubMed: PMID 25424991 · NCT01972035 · Cytomegalovirus Infections

2014 (4 papers)

  1. A randomized controlled pilot trial of valacyclovir for attenuating inflammation and immune activation in HIV/herpes simplex virus 2-coinfected adults on suppressive antiretroviral therapy.
    Yi TJ, Walmsley S, Szadkowski L, et al. · Clin Infect Dis · 2014 · Trial result
    PubMed: PMID 23946220 · NCT01176409 (VALIANT Pilot) · Herpes Simplex
  2. Valacyclovir therapy does not reverse herpes-associated alterations in cervical immunology: a randomized, placebo-controlled crossover trial.
    Yi TJ, Shannon B, Chieza L, et al. · J Infect Dis · 2014 · Derived
    PubMed: PMID 24664172 · NCT00946556 · HIV Infections
  3. Maternal valacyclovir and infant cytomegalovirus acquisition: a randomized controlled trial among HIV-infected women.
    Roxby AC, Atkinson C, Asbjörnsdóttir K, et al. · PLoS One · 2014 · Derived
    PubMed: PMID 24504006 · NCT00530777 (VIP) · Herpes Simplex
  4. Antiherpes virus-specific treatment and cognition in schizophrenia: a test-of-concept randomized double-blind placebo-controlled trial.
    Prasad KM, Eack SM, Keshavan MS, et al. · Schizophr Bull · 2014 · Derived
    PubMed: PMID 22446565 · NCT00514449 (SEAMS) · Psychotic Disorders

2013 (2 papers)

  1. Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir.
    Roxby AC, Liu AY, Drake AL, et al. · AIDS Res Hum Retroviruses · 2013 · Derived
    PubMed: PMID 22852760 · NCT00530777 (VIP) · Herpes Simplex
  2. Immunogenic cell death in cancer therapy.
    Kroemer G, Galluzzi L, Kepp O, et al. · Annu Rev Immunol · 2013 · Background
    PubMed: PMID 23157435 · NCT03541928 · Prostatic Neoplasms

2012 (8 papers)

  1. Valomaciclovir versus valacyclovir for the treatment of acute herpes zoster in immunocompetent adults: a randomized, double-blind, active-controlled trial.
    Tyring SK, Plunkett S, Scribner AR, et al. · J Med Virol · 2012 · Trial result
    PubMed: PMID 22711350 · NCT00831103 · Herpes Zoster
  2. High-dose valacyclovir HSV-2 suppression results in greater reduction in plasma HIV-1 levels compared with standard dose acyclovir among HIV-1/HSV-2 coinfected persons: a randomized, crossover trial.
    Mugwanya K, Baeten JM, Mugo NR, et al. · J Infect Dis · 2012 · Derived
    PubMed: PMID 21998479 · NCT01026454 (ACV-VAL) · Herpes Simplex
  3. Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials.
    Johnston C, Saracino M, Kuntz S, et al. · Lancet · 2012 · Derived
    PubMed: PMID 22225814 · NCT00362297 · Herpes Genitalis
  4. Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial.
    Drake AL, Roxby AC, Ongecha-Owuor F, et al. · J Infect Dis · 2012 · Derived
    PubMed: PMID 22147786 · NCT00530777 (VIP) · Herpes Simplex
  5. Infant safety during and after maternal valacyclovir therapy in conjunction with antiretroviral HIV-1 prophylaxis in a randomized clinical trial.
    Drake AL, Roxby AC, Kiarie J, et al. · PLoS One · 2012 · Derived
    PubMed: PMID 22509337 · NCT00530777 (VIP) · Herpes Simplex
  6. ASP2151 for the treatment of genital herpes: a randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study.
    Tyring S, Wald A, Zadeikis N, et al. · J Infect Dis · 2012 · Background
    PubMed: PMID 22351940 · NCT00486200 · Herpes Genitalis
  7. The convergence of radiation and immunogenic cell death signaling pathways.
    Golden EB, Pellicciotta I, Demaria S, et al. · Front Oncol · 2012 · Background
    PubMed: PMID 22891162 · NCT03541928 · Prostatic Neoplasms
  8. Congenital cytomegalovirus infection: current strategies and future perspectives.
    Buonsenso D, Serranti D, Gargiullo L, et al. · Eur Rev Med Pharmacol Sci · 2012 · Background
    PubMed: PMID 22953641 · NCT02351102 · Cytomegalovirus Infections

2011 (5 papers)

  1. Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma.
    Chiocca EA, Aguilar LK, Bell SD, et al. · J Clin Oncol · 2011 · Trial result
    PubMed: PMID 21844505 · NCT00751270 (BrTK01) · Glioblastoma
  2. Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study.
    Lapolla W, Digiorgio C, Haitz K, et al. · Arch Dermatol · 2011 · Derived
    PubMed: PMID 21482862 · NCT01250561 · Herpes Zoster
  3. Can herpes simplex virus type 2 suppression slow HIV disease progression: a study protocol for the VALacyclovir In Delaying Antiretroviral Treatment Entry (VALIDATE) trial.
    Tan DH, Raboud JM, Kaul R, et al. · Trials · 2011 · Background
    PubMed: PMID 21106086 · NCT00860977 (VALIDATE) · Herpes Genitalis
  4. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
    Ferlay J, Shin HR, Bray F, et al. · Int J Cancer · 2011 · Background
    PubMed: PMID 21351269 · NCT03541928 · Prostatic Neoplasms
  5. Dose escalation and quality of life in patients with localized prostate cancer treated with radiotherapy: long-term results of the Dutch randomized dose-escalation trial (CKTO 96-10 trial).
    Al-Mamgani A, van Putten WL, van der Wielen GJ, et al. · Int J Radiat Oncol Biol Phys · 2011 · Background
    PubMed: PMID 20421153 · NCT03541928 · Prostatic Neoplasms

2010 (1 paper)

  1. Human cytomegalovirus in utero transmission: follow-up of 524 maternal seroconversions.
    Bodéus M, Kabamba-Mukadi B, Zech F, et al. · J Clin Virol · 2010 · Background
    PubMed: PMID 20006542 · NCT02351102 · Cytomegalovirus Infections

2009 (6 papers)

  1. HSV suppression reduces seminal HIV-1 levels in HIV-1/HSV-2 co-infected men who have sex with men.
    Zuckerman RA, Lucchetti A, Whittington WL, et al. · AIDS · 2009 · Derived
    PubMed: PMID 19169140 · NCT00378976 · Herpes Simplex
  2. Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial.
    Hull C, McKeough M, Sebastian K, et al. · J Eur Acad Dermatol Venereol · 2009 · Derived
    PubMed: PMID 19143902 · NCT00297011 · Herpes Labialis
  3. Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance.
    Bodsworth N, Fife K, Koltun W, et al. · Curr Med Res Opin · 2009 · Derived
    PubMed: PMID 19192993 · NCT00306787 · Herpes Simplex
  4. Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial.
    Baeten JM, Strick LB, Lucchetti A, et al. · J Infect Dis · 2009 · Derived
    PubMed: PMID 18928378 · NCT00465205 · Herpes Simplex
  5. Long-term administration of valacyclovir reduces the number of Epstein-Barr virus (EBV)-infected B cells but not the number of EBV DNA copies per B cell in healthy volunteers.
    Hoshino Y, Katano H, Zou P, et al. · J Virol · 2009 · Background
    PubMed: PMID 19740997 · NCT07294547 · Cytomegalovirus Infections
  6. Final report of multicenter Canadian Phase III randomized trial of 3 versus 8 months of neoadjuvant androgen deprivation therapy before conventional-dose radiotherapy for clinically localized prostate cancer.
    Crook J, Ludgate C, Malone S, et al. · Int J Radiat Oncol Biol Phys · 2009 · Background
    PubMed: PMID 18707821 · NCT03541928 · Prostatic Neoplasms

2008 (6 papers)

  1. Management of peripheral facial nerve palsy.
    Finsterer J · Eur Arch Otorhinolaryngol · 2008 · Trial result
    PubMed: PMID 18368417 · NCT01686464 · Bell Palsy
  2. Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial.
    Zuckerman RA, Lucchetti A, Whittington WL, et al. · J Infect Dis · 2008 · Derived
    PubMed: PMID 18008230 · NCT00378976 · Herpes Simplex
  3. Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy.
    O'Brien S, Ravandi F, Riehl T, et al. · Blood · 2008 · Derived
    PubMed: PMID 18039954 · NCT00562770 · Leukemia
  4. Roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (HIV-1)-induced immunosuppression on genital and plasma HIV-1 levels.
    Nagot N, Ouedraogo A, Konate I, et al. · J Infect Dis · 2008 · Derived
    PubMed: PMID 18593294 · NCT00158509 · Herpes Genitalis
  5. Effect of HIV-1 and antiretroviral therapy on herpes simplex virus type 2: a prospective study in African women.
    Mayaud P, Nagot N, Konaté I, et al. · Sex Transm Infect · 2008 · Derived
    PubMed: PMID 18596069 · NCT00158509 · Herpes Genitalis
  6. The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.
    Dickerson FB, Boronow JJ, Stallings C, et al. · Schizophr Res · 2008 · Background
    PubMed: PMID 17601704 · NCT00428298 · Bipolar Disorder

2007 (8 papers)

  1. Maternal administration of valaciclovir in symptomatic intrauterine cytomegalovirus infection.
    Jacquemard F, Yamamoto M, Costa JM, et al. · BJOG · 2007 · Trial result
    PubMed: PMID 17617198 · NCT02351102 · Cytomegalovirus Infections
  2. Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus.
    Nagot N, Ouédraogo A, Foulongne V, et al. · N Engl J Med · 2007 · Derived
    PubMed: PMID 17314338 · NCT00158509 · Herpes Genitalis
  3. Radical prostatectomy for clinically localized, high risk prostate cancer: critical analysis of risk assessment methods.
    Yossepowitch O, Eggener SE, Bianco FJ, et al. · J Urol · 2007 · Background
    PubMed: PMID 17561152 · NCT03541928 · Prostatic Neoplasms
  4. Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines.
    Workowski KA, Berman SM · Clin Infect Dis · 2007 · Background
    PubMed: PMID 17342670 · NCT00530777 (VIP) · Herpes Simplex
  5. Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract.
    Rebbapragada A, Wachihi C, Pettengell C, et al. · AIDS · 2007 · Background
    PubMed: PMID 17314521 · NCT00946556 · HIV Infections
  6. Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia.
    Prasad KM, Shirts BH, Yolken RH, et al. · Mol Psychiatry · 2007 · Background
    PubMed: PMID 17033628 · NCT00514449 (SEAMS) · Psychotic Disorders
  7. Phase I trial of replication-competent adenovirus-mediated suicide gene therapy combined with IMRT for prostate cancer.
    Freytag SO, Movsas B, Aref I, et al. · Mol Ther · 2007 · Background
    PubMed: PMID 17375076 · NCT03541928 · Prostatic Neoplasms
  8. Herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission.
    Drake AL, John-Stewart GC, Wald A, et al. · Obstet Gynecol · 2007 · Background
    PubMed: PMID 17267842 · NCT00530777 (VIP) · Herpes Simplex

2006 (8 papers)

  1. Valacyclovir prophylaxis to prevent recurrent herpes at delivery: a randomized clinical trial.
    Sheffield JS, Hill JB, Hollier LM, et al. · Obstet Gynecol · 2006 · Background
    PubMed: PMID 16816068 · NCT00530777 (VIP) · Herpes Simplex
  2. Genital shedding of herpes simplex virus type 2 in childbearing-aged and pregnant women living in Gabon.
    Ozouaki F, Ndjoyi-Mbiguino A, Legoff J, et al. · Int J STD AIDS · 2006 · Background
    PubMed: PMID 16464276 · NCT00530777 (VIP) · Herpes Simplex
  3. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy.
    Ornoy A, Diav-Citrin O · Reprod Toxicol · 2006 · Background
    PubMed: PMID 16580941 · NCT02351102 · Cytomegalovirus Infections
  4. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies.
    Freeman EE, Weiss HA, Glynn JR, et al. · AIDS · 2006 · Background
    PubMed: PMID 16327322 · NCT01026454 (ACV-VAL) · Herpes Simplex
  5. Chronic herpes simplex virus type-2 infection and HIV viral load.
    Duffus WA, Mermin J, Bunnell R, et al. · Int J STD AIDS · 2006 · Background
    PubMed: PMID 16303067 · NCT00530777 (VIP) · Herpes Simplex
  6. Genital herpes simplex virus infection and perinatal transmission of human immunodeficiency virus.
    Chen KT, Segú M, Lumey LH, et al. · Obstet Gynecol · 2006 · Background
    PubMed: PMID 16319261 · NCT00530777 (VIP) · Herpes Simplex
  7. High risk of human immunodeficiency virus in men who have sex with men with herpes simplex virus type 2 in the EXPLORE study.
    Brown EL, Wald A, Hughes JP, et al. · Am J Epidemiol · 2006 · Background
    PubMed: PMID 16896053 · NCT01026454 (ACV-VAL) · Herpes Simplex
  8. Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.
    Andrews WW, Kimberlin DF, Whitley R, et al. · Am J Obstet Gynecol · 2006 · Background
    PubMed: PMID 16522412 · NCT00530777 (VIP) · Herpes Simplex

2005 (5 papers)

  1. Longitudinal assessment of HIV-1 and HSV-2 shedding in the genital tract of West African women.
    Nagot N, Foulongne V, Becquart P, et al. · J Acquir Immune Defic Syndr · 2005 · Trial result
    PubMed: PMID 16044019 · NCT00158509 · Herpes Genitalis
  2. HSV-1 DNA in tears and saliva of normal adults.
    Kaufman HE, Azcuy AM, Varnell ED, et al. · Invest Ophthalmol Vis Sci · 2005 · Background
    PubMed: PMID 15623779 · NCT00587496 · Herpes Simplex
  3. Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival.
    Iliff PJ, Piwoz EG, Tavengwa NV, et al. · AIDS · 2005 · Background
    PubMed: PMID 15821396 · NCT00530777 (VIP) · Herpes Simplex
  4. Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer.
    Gulley JL, Arlen PM, Bastian A, et al. · Clin Cancer Res · 2005 · Background
    PubMed: PMID 15867235 · NCT03541928 · Prostatic Neoplasms
  5. Acetylsalicylic acid reduces viral shedding induced by thermal stress.
    Gebhardt BM, Varnell ED, Kaufman HE, et al. · Curr Eye Res · 2005 · Background
    PubMed: PMID 15512958 · NCT00587496 · Herpes Simplex

2004 (6 papers)

  1. Phase I-II trial evaluating combined intensity-modulated radiotherapy and in situ gene therapy with or without hormonal therapy in treatment of prostate cancer-interim report on PSA response and biopsy data.
    Teh BS, Ayala G, Aguilar L, et al. · Int J Radiat Oncol Biol Phys · 2004 · Background
    PubMed: PMID 15050332 · NCT03541928 · Prostatic Neoplasms
  2. Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer.
    Freytag SO, Stricker H, Pegg J, et al. · Cancer Res · 2004 · Background
    PubMed: PMID 14612551 · NCT03541928 · Prostatic Neoplasms
  3. Reduction of symptoms by valacyclovir in cytomegalovirus-seropositive individuals with schizophrenia.
    Dickerson FB, Boronow JJ, Stallings CR, et al. · Am J Psychiatry · 2004 · Background
    PubMed: PMID 14638597 · NCT00428298 · Bipolar Disorder
  4. Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder.
    Dickerson FB, Boronow JJ, Stallings C, et al. · Biol Psychiatry · 2004 · Background
    PubMed: PMID 15013827 · NCT00428298 · Bipolar Disorder
  5. Use of antiviral drugs to prevent herpesvirus transmission.
    Crumpacker CS · N Engl J Med · 2004 · Background
    PubMed: PMID 14702430 · NCT00587496 · Herpes Simplex
  6. Once-daily valacyclovir to reduce the risk of transmission of genital herpes.
    Corey L, Wald A, Patel R, et al. · N Engl J Med · 2004 · Background
    PubMed: PMID 14702423 · NCT00587496 · Herpes Simplex

2003 (2 papers)

  1. Combining radiotherapy with gene therapy (from the bench to the bedside): a novel treatment strategy for prostate cancer.
    Teh BS, Aguilar-Cordova E, Vlachaki MT, et al. · Oncologist · 2003 · Background
    PubMed: PMID 12401909 · NCT03541928 · Prostatic Neoplasms
  2. Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression.
    Schacker T, Zeh J, Hu H, et al. · J Infect Dis · 2003 · Background
    PubMed: PMID 12447756 · NCT01026454 (ACV-VAL) · Herpes Simplex

2002 (3 papers)

  1. Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection: relationship to CMV disease.
    Nokta MA, Holland F, De Gruttola V, et al. · J Infect Dis · 2002 · Background
    PubMed: PMID 12085316 · NCT00001038 · HIV Infections
  2. Congenital cytomegalovirus infection: review of the epidemiology and outcome.
    Gaytant MA, Steegers EA, Semmekrot BA, et al. · Obstet Gynecol Surv · 2002 · Background
    PubMed: PMID 11961482 · NCT02351102 · Cytomegalovirus Infections
  3. Valaciclovir versus aciclovir for herpes simplex virus infection in HIV-infected individuals: two randomized trials.
    Conant MA, Schacker TW, Murphy RL, et al. · Int J STD AIDS · 2002 · Background
    PubMed: PMID 11802924 · NCT00530777 (VIP) · Herpes Simplex

2000 (2 papers)

  1. Detection of Herpes simplex virus DNA by real-time PCR.
    Kessler HH, Mühlbauer G, Rinner B, et al. · J Clin Microbiol · 2000 · Background
    PubMed: PMID 10878056 · NCT00587496 · Herpes Simplex
  2. Short-course antenatal zidovudine reduces both cervicovaginal human immunodeficiency virus type 1 RNA levels and risk of perinatal transmission. Bangkok Collaborative Perinatal HIV Transmission Study Group.
    Chuachoowong R, Shaffer N, Siriwasin W, et al. · J Infect Dis · 2000 · Background
    PubMed: PMID 10608756 · NCT00530777 (VIP) · Herpes Simplex

1999 (7 papers)

  1. Maternal virus load and perinatal human immunodeficiency virus type 1 subtype E transmission, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group.
    Shaffer N, Roongpisuthipong A, Siriwasin W, et al. · J Infect Dis · 1999 · Background
    PubMed: PMID 9952365 · NCT00530777 (VIP) · Herpes Simplex
  2. Development of a high-throughput quantitative assay for detecting herpes simplex virus DNA in clinical samples.
    Ryncarz AJ, Goddard J, Wald A, et al. · J Clin Microbiol · 1999 · Background
    PubMed: PMID 10325351 · NCT00587496 · Herpes Simplex
  3. Rapid method for screening dried blood samples on filter paper for human immunodeficiency virus type 1 DNA.
    Panteleeff DD, John G, Nduati R, et al. · J Clin Microbiol · 1999 · Background
    PubMed: PMID 9889216 · NCT00530777 (VIP) · Herpes Simplex
  4. Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team.
    Mofenson LM, Lambert JS, Stiehm ER, et al. · N Engl J Med · 1999 · Background
    PubMed: PMID 10432323 · NCT00530777 (VIP) · Herpes Simplex
  5. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group.
    Garcia PM, Kalish LA, Pitt J, et al. · N Engl J Med · 1999 · Background
    PubMed: PMID 10432324 · NCT00530777 (VIP) · Herpes Simplex
  6. 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Côte d'Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial. DITRAME Study Group. DIminution de la Transmission Mère-Enfant.
    Dabis F, Msellati P, Meda N, et al. · Lancet · 1999 · Background
    PubMed: PMID 10459959 · NCT00530777 (VIP) · Herpes Simplex
  7. Recent advances in varicella-zoster virus infection.
    Cohen JI, Brunell PA, Straus SE, et al. · Ann Intern Med · 1999 · Background
    PubMed: PMID 10375341 · NCT00001054 · Herpes Simplex

1998 (4 papers)

  1. Mechanisms and timing of mother-to-child transmission of HIV-1.
    Newell ML · AIDS · 1998 · Background
    PubMed: PMID 9631135 · NCT00530777 (VIP) · Herpes Simplex
  2. Pharmacokinetics of oral valacyclovir and acyclovir in late pregnancy.
    Kimberlin DF, Weller S, Whitley RJ, et al. · Am J Obstet Gynecol · 1998 · Background
    PubMed: PMID 9790357 · NCT00530777 (VIP) · Herpes Simplex
  3. A randomized, double-blind trial of valaciclovir prophylaxis for cytomegalovirus disease in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group.
    Feinberg JE, Hurwitz S, Cooper D, et al. · J Infect Dis · 1998 · Background
    PubMed: PMID 9419169 · NCT00001038 · HIV Infections
  4. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group.
    N Engl J Med · 1998 · Background
    PubMed: PMID 9696640 · NCT00587496 · Herpes Simplex

1997 (4 papers)

  1. Detection of herpes simplex virus type 1 shedding in the oral cavity by polymerase chain reaction and enzyme-linked immunosorbent assay at the prodromal stage of recrudescent herpes labialis.
    Scott DA, Coulter WA, Biagioni PA, et al. · J Oral Pathol Med · 1997 · Background
    PubMed: PMID 9250929 · NCT00587496 · Herpes Simplex
  2. The impact of active herpes simplex virus infection on human immunodeficiency virus load.
    Mole L, Ripich S, Margolis D, et al. · J Infect Dis · 1997 · Background
    PubMed: PMID 9291329 · NCT00530777 (VIP) · Herpes Simplex
  3. Evaluation of a quantitative competitive PCR assay for measuring herpes simplex virus DNA content in genital tract secretions.
    Hobson A, Wald A, Wright N, et al. · J Clin Microbiol · 1997 · Background
    PubMed: PMID 9041386 · NCT00587496 · Herpes Simplex
  4. Manifestations resembling thrombotic microangiopathy in patients with advanced human immunodeficiency virus (HIV) disease in a cytomegalovirus prophylaxis trial (ACTG 204).
    Bell WR, Chulay JD, Feinberg JE, et al. · Medicine (Baltimore) · 1997 · Background
    PubMed: PMID 9352739 · NCT00001038 · HIV Infections

1996 (1 paper)

  1. Frequent recurrence and persistence of varicella-zoster virus infections in children infected with human immunodeficiency virus type 1.
    von Seidlein L, Gillette SG, Bryson Y, et al. · J Pediatr · 1996 · Background
    PubMed: PMID 8551421 · NCT00001054 · Herpes Simplex

1995 (2 papers)

  1. The possible contributing factors for the success of steroid therapy in Bell's palsy: a clinical and electrophysiological study.
    Shafshak TS, Essa AY, Bakey FA, et al. · J Laryngol Otol · 1995 · Trial result
    PubMed: PMID 7829945 · NCT01686464 · Bell Palsy
  2. Prostate-specific antigen and radiation therapy for clinically localized prostate cancer.
    Zagars GK, Pollack A, Kavadi VS, et al. · Int J Radiat Oncol Biol Phys · 1995 · Background
    PubMed: PMID 7538498 · NCT03541928 · Prostatic Neoplasms

1988 (1 paper)

  1. Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera.
    Ashley RL, Militoni J, Lee F, et al. · J Clin Microbiol · 1988 · Background
    PubMed: PMID 2835389 · NCT00530777 (VIP) · Herpes Simplex

1970 (1 paper)

  1. A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans.
    Douglas RG, Couch RB · J Immunol · 1970 · Background
    PubMed: PMID 4312871 · NCT00587496 · Herpes Simplex

1968 (1 paper)

  1. Significance of Herpesvirus hominis in respiratory secretions of man.
    Lindgren KM, Douglas RG, Couch RB, et al. · N Engl J Med · 1968 · Background
    PubMed: PMID 4295319 · NCT00587496 · Herpes Simplex

Sources and methodology

This page summarizes published evidence for general reference and does not constitute medical advice. For clinical decisions, consult the linked primary publications and your healthcare provider. Data sourced from PubMed and the ClinicalTrials.gov / AACT database maintained by the Clinical Trials Transformation Initiative (CTTI).