Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding

Sponsor
French National Agency for Research on AIDS and Viral Hepatitis
Study ID
NCT00158509
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
FEMALE
Age
16 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

Genital herpes is a long-life sexually transmitted diseases which infects a large proportion of women in Africa. Its clinical symptoms are painful sores on the genitals, which heals after a few days. HIV infection can worsen genital herpes. In turn, it is possible that genital herpes increases the quantity of HIV secreted at the genital level in women infected by the 2 viruses. This study is dedicated to verify this hypothesis.

Key Dates

Start date
Aug 31, 2004
Status verified
Jun 2006
Completion
Jul 31, 2005

Study Design

Enrollment
215 participants
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Primary Outcome Measure

To assess the impact of HSV-2 suppressive therapy on HIV shedding among co-infected women taking highly active antiretroviral therapy (HAART) or not needing HAART

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