The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection

Part of paid clinical trials in New York, New York.

Sponsor
Icahn School of Medicine at Mount Sinai
Study ID
NCT05652088
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Colonoscopy — PROCEDURE
    Colonoscopy is a procedure where an instrument called colonoscope is inserted through the rectum to look at the entire internal surface of the intestine. Participants will be placed on a stretcher on the left side. A colonoscope will be advanced into the colon and into the terminal ileum. The entire procedure should take approximately 40 minutes

Study Details

The objective of this study is to understand the effects of HIV cure strategies on the virus and immune cells that reside within the gastrointestinal tract. Subjects receiving therapies with the potential for HIV cure will undergo a colonoscopy to obtain gastrointestinal tissue for research assays. This study will test whether receiving these therapies will induce changes in the immune cells in the gastrointestinal tract and reduce the tissue-associated HIV viral levels.

Key Dates

Start date
Jun 30, 2023
Status verified
Jul 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Patients with HIV Therapy
    Subjects receiving therapies with the potential for HIV cure

Primary Outcome Measure

Change in HIV tissue viral load [ Time Frame: End of the study (at month one) compared to baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Icahn School of Medicine at Mount SinaiNew YorkNew York10029
Francesca Cossarini, MD
[email protected]
212-659-9269
Saurabh Mehandru, MD
[email protected]
212-659-9206
Francesca Cossarini (PRINCIPAL_INVESTIGATOR)

Find similar trials in New York, NY

By condition
HIV
By specialty
Infectious disease
By research site
Icahn School of Medicine at Mount Sinai· New York, NY

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