The Safety and Effectiveness of Valacyclovir HCl in the Treatment of Herpes Simplex or Varicella/Zoster Infections in HIV-1 Infected Children

Conditions

• Chickenpox
• HIV Infections
• Herpes Simplex

Eligibility Criteria

Sex

ALL

Age

4 Years - 12 Years

Healthy Volunteers

Not accepted

Interventions

• Valacyclovir hydrochloride — DRUG

Study Details

To obtain tolerance, safety, and pharmacokinetic data for oral valacyclovir hydrochloride ( 256U87 ) in HIV-1 infected children with herpes simplex virus infections ( cold sores ) and/or varicella / zoster virus infections ( chicken pox / shingles ). Varicella and zoster are common problems in HIV-infected children. It is believed that chronic oral therapy with acyclovir may result in subtherapeutic concentrations of acyclovir, resulting in resistance to that drug. Valacyclovir hydrochloride, which converts to acyclovir in the body, increases acyclovir bioavailability by 3-5 fold.

Key Dates

Status verified

Oct 2021

Completion

Jan 31, 2001

Study Design

Enrollment

0 participants (actual)

Primary purpose

TREATMENT

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