Iron Absorption in The Low Oxygen Exposure and Weight Status (LOWS) Study

Part of paid clinical trials in Baton Rouge, Louisiana.

Sponsor
Pennington Biomedical Research Center
Study ID
NCT07542873
Status
Recruiting
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Conditions

  • Obesity (Disorder)

Eligibility Criteria

Sex
ALL
Age
22 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Normobaric hypoxia (NH) — OTHER
    Low oxygen exposure to mimic \~8500 feet elevation (experimental)
  • Normobaric normoxia (NN) — OTHER
    Normal oxygen exposure to mimic sea level conditions (sham comparator).

Study Details

Declines in iron status are common in those with obesity and may be due to obesity-related chronic inflammation; however, the effects of reducing inflammation following diet-induced weight loss on iron metabolism are poorly understood. Low environmental oxygen exposure increases dietary iron absorption and availability to supply iron for erythropoiesis but has not yet been tested in the context of weight loss. This study is designed to investigate diet-induced weight loss (inflammation reduction) and overnight low oxygen exposure (erythropoiesis stimulating agent) as strategies to improve dietary iron absorption in obesity.

Key Dates

Start date
Apr 21, 2025
Status verified
Apr 2026
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Normobaric hypoxia (NH)
    8 weeks of overnight exposure (8 hrs/night) to NH conditions (\~15% oxygen; achieved with nitrogen dilution, equivalent to \~8500 feet elevation) using a commercially available tent and generator system (Hypoxico, Inc., New York, NY).
  • Sham Comparator: Normobaric normoxia (NN)
    8 weeks of overnight exposure (8 hrs/night) to NN conditions (\~21% oxygen; sea level) using a commercially available tent and generator system (Hypoxico, Inc., New York, NY).

Primary Outcome Measure

Change in iron absorption [ Time Frame: 7 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Pennington Biomedical Research CenterBaton RougeLouisiana70808
Recruitment Core
[email protected]
225-763-3000

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Pennington Biomedical Research Center· Baton Rouge, LA

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