The Effects of Acute Erythropoietin on Hepcidin and Dietary Iron Absorption Following Military-relevant Exercise in Energy Deficit: Pilot Study

Part of paid clinical trials in Baton Rouge, Louisiana.

Sponsor
Pennington Biomedical Research Center
Study ID
NCT07517562
Status
Active Not Recruiting

Conditions

  • Iron Absorption

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise test — OTHER
    90-minute load carriage exercise test on a treadmill

Study Details

Military personnel frequently experience declines in iron status during training and when in the field, which may compromise performance. The overall purpose of this study is to determine why the decline in iron status occurs and potential countermeasures. Participants will be given an acute dose of erythropoietin (EPO) or placebo and will complete a 90-minute load carriage exercise test. Prior to the main trial, this pilot study will determine the optimal approach to assess iron absorption following exercise (red blood cell incorporation or plasma isotope appearance), the percentage of iron incorporated into red blood cells with EPO compared to placebo, and the timing of the intervention.

Key Dates

Start date
Sep 1, 2025
Status verified
Jun 2025
Primary completion
Dec 31, 2025
Completion
May 1, 2026

Study Design

Enrollment
6 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: EPO
    Recombinant human erythropoietin (EPO)
  • Placebo Comparator: Placebo
    Saline placebo

Primary Outcome Measure

Fractional iron absorption [ Time Frame: 14 days post-exercise ]

Locations (1)

FacilityCityStateZIPSite coordinators
LSU Pennington Biomedical Research CenterBaton RougeLouisiana70808-

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LSU Pennington Biomedical Research Center· Baton Rouge, LA

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