AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Part of paid clinical trials in Anniston, Alabama.

Sponsor
Novo Nordisk A/S
Study ID
NCT07503210
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Key Dates

Start date
Apr 21, 2026
Status verified
Jun 2026
Primary completion
Jun 6, 2028
Completion
Jul 4, 2028

Study Design

Enrollment
600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: NNC0487-0111
    Participants will receive subcutaneous injection of NNC0487-0111 once weekly as an adjunct to a reduced-calorie diet and increased physical activity.
  • Placebo Comparator: Placebo
    Participants will receive subcutaneous injection of placebo matched to NNC0487-0111 once weekly as an adjunct to a reduced-calorie diet and increased physical activity.

Primary Outcome Measure

Relative change in body weight [ Time Frame: From week 40 to week 92 ]

Central Contacts

Locations (13)

FacilityCityStateZIPSite coordinators
Pinnacle Research Group LLCAnnistonAlabama36207-
Diablo Clinical Research, Inc.Walnut CreekCalifornia94598-
Florida Inst For Clin Res LLCOrlandoFlorida32825-
Endeavor HealthSkokieIllinois60077-
Midwest Inst For Clin ResIndianapolisIndiana46260-
Medication Mgmnt, LLC_GrnsboroGreensboroNorth Carolina27405-
PMG Research of Wilmington LLCWilmingtonNorth Carolina28401-
UPA Ctr Weight and Eating DisPhiladelphiaPennsylvania19104-
Clinical Res CollaborativeCumberlandRhode Island02864-
North Texas Endocrine CenterDallasTexas75231-
UT Southwestern Med CntrDallasTexas75390-9302-
Selma Medical AssociatesWinchesterVirginia22601-3834-
Rainier Clin Res Ctr IncRentonWashington98057-

Find similar trials in Anniston, AL

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Pinnacle Research Group LLC· Anniston, ALDiablo Clinical Research, Inc.· Walnut Creek, CAFlorida Inst For Clin Res LLC· Orlando, FLEndeavor Health· Skokie, ILMidwest Inst For Clin Res· Indianapolis, INMedication Mgmnt, LLC_Grnsboro· Greensboro, NC

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