DNA Methylation and Vascular Function

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Illinois at Chicago
Study ID
NCT03527420
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise training — OTHER
    Twelve weeks of aerobic exercise training

Study Details

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Key Dates

Start date
Oct 11, 2019
Status verified
Sep 2025
Primary completion
Jun 30, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Exercising
    12 weeks of aerobic exercise training
  • No Intervention: Non-exercising
    standard of care

Primary Outcome Measure

DNA methylation status of adipocytokines in obese individuals [ Time Frame: Month 24-30 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Illinois at ChicagoChicagoIllinois60612
Abeer M Mohamed, MD, PhD
[email protected]
312-355-8099

Find similar trials in Chicago, IL

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Illinois at Chicago· Chicago, IL

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