Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT07463742
Status
Not Yet Recruiting

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Conditions

  • Tracheal Stenosis

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Bronchoscopy, carbon dioxide (CO2) laser wedge resection — PROCEDURE
    CO2 laser wedge resection - removing scar tissue with laser, leading tissue bridges.
  • Radial incision with dilation — PROCEDURE
    Radial incision with dilation - making radial cuts at the circumferential scar site, followed by balloon dilation.

Study Details

Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe. Doctors often treat this by using a bronchoscope-a thin, flexible tube with a camera-to open up the airway or remove scar tissue. While these procedures help patients breathe better, we do not fully understand why the narrowing occurs or how the tissue heals afterward. The purpose of this study is to better understand the biological changes in the airway tissue before and after these standard medical procedures. During the procedure, small samples of tissue that would already be collected as part of normal care will be analyzed in the laboratory. The results may help doctors learn more about airway healing and could guide better treatments in the future.

Key Dates

Start date
May 1, 2026
Status verified
Mar 2026
Primary completion
May 1, 2031
Completion
May 1, 2032

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Carbon dioxide (CO2) laser wedge resection
  • Active Comparator: Radial incision and dilation

Primary Outcome Measure

Change in transcriptomic pathway activation scores [ Time Frame: at the time of the second procedure (1 month from the initial invervention) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MarylandBaltimoreMaryland21021
Chenchen Zhang, MD
[email protected]
410-328-8138

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By research site
University of Maryland· Baltimore, MD

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