RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT07258784
Status
Recruiting
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Conditions

  • Subglottic Stenosis
  • Tracheal Stenosis

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Biopsy or surgery — PROCEDURE
    The tissue will be obtained from biopsy or surgical resection. All the "intervention" will be performed for clinical needs. The tissue used in the study will be considered as discarded tissue

Study Details

Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

Key Dates

Start date
Sep 11, 2025
Status verified
Sep 2025
Primary completion
Sep 10, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
10 participants (estimated)

Arms

  • Arm: patients with benign tracheal stenosis undergoing either endoscopic or surgical treatment

Primary Outcome Measure

RNA profile [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MarylandBaltimoreMaryland21201
Chenchen Zhang
[email protected]
4103288141

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By research site
University of Maryland· Baltimore, MD

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