Exercise and Carotid Artery Function in Metabolic Syndrome

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT07430839
Status
Recruiting
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Conditions

  • Metabolic Syndrome

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • exercise — BEHAVIORAL
    30 minute bout of cycling
  • Diagnostics — DIAGNOSTIC_TEST
    * Doppler Ultrasound used to non-invasively assess the diameter and blood flow going into an artery, the ICA in this study. * Indirect calorimeter in tandem with semi-recumbent bike used to assess O2 consumption * heart rate monitor
  • Inhaled CO2-mixed air — OTHER
    Three gases of different composition are used to ensure that the proper PETCO2 administration desired for this study occurs in tandem with keeping inspired O2 content constant. This is achieved by used a 5% O2, 95% CO2 tank, a 5% O2, 95% N2 tank, and a 100% O2 tank. In tandem, the use of these three tanks allows for precise control of PETCO2 without a change in inspired O2.

Study Details

The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.

Key Dates

Start date
Dec 1, 2025
Status verified
Feb 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
48 participants (estimated)

Arms

  • Arm: Young Male adults with MetSyn
    * Graded Exercise Trial to determine cardiorespiratory fitness * Submaximal Exercise Trial to assess primary aims of the study (ICA function will be assessed using the cSMD test) * Sitting Control Trial (ICA function will be assessed using the cSMD test)
  • Arm: Young Female adults with MetSyn
    * Graded Exercise Trial to determine cardiorespiratory fitness * Submaximal Exercise Trial to assess primary aims of the study (ICA function will be assessed using the cSMD test) * Sitting Control Trial (ICA function will be assessed using the cSMD test)
  • Arm: Young Male Healthy Controls
    * Graded Exercise Trial to determine cardiorespiratory fitness * Submaximal Exercise Trial to assess primary aims of the study (ICA function will be assessed using the cSMD test) * Sitting Control Trial (ICA function will be assessed using the cSMD test)
  • Arm: Young Female Healthy Controls
    * Graded Exercise Trial to determine cardiorespiratory fitness * Submaximal Exercise Trial to assess primary aims of the study (ICA function will be assessed using the cSMD test) * Sitting Control Trial (ICA function will be assessed using the cSMD test)

Primary Outcome Measure

Aim 1: Baseline ICA cSMD measures assessed by MetSyn versus healthy controls [ Time Frame: baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of WisconsinMadisonWisconsin53792-

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By research site
University of Wisconsin· Madison, WI

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