Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT03215836
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Bronchoscopy and Nasal Epithelium Brush Sampling — PROCEDURE
    After meeting screening criteria, participants will undergo further evaluation to determine whether or not inclusion and exclusion criteria are met. Participants will undergo a baseline evaluation, lung function testing and a subsequent bronchoscopy and nasal epithelial brush sampling in those that meet study enrollment.

Study Details

The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology. To do so, the investigators want to determine how obesity and the metabolic syndrome relate to metabolism in bronchial airway epithelial cells and the nasal epithelium.

Key Dates

Start date
Aug 10, 2017
Status verified
Feb 2023
Primary completion
Mar 10, 2027
Completion
Dec 31, 2029

Study Design

Enrollment
50 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Other: Obese Asthmatics
    BMI \>/= 30 and without metabolic syndrome
  • Other: Obese Astmatics
    BMI \>/= 30 and with metabolic syndrome
  • Other: Obese non-asthmatics
    BMI \>/= 30
  • Other: Non - obese asthmatics
    BMI: lean \> 20; Normal \>/= 20 to \<25; overweight \</= 25 to \< 30;

Primary Outcome Measure

Measurement of L-arginine-NO biosynthesis pathways in the airway epithelium in obese and non-asthmatics. [ Time Frame: Within 6 months of collection ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of ColoradoAuroraColorado80045
Asthma Research
[email protected]
844-365-0852

Find similar trials in Aurora, CO

By condition
AsthmaObesity / overweight
By specialty
PulmonologyLung diseaseEndocrinologyMetabolic healthWeight loss
By research site
University of Colorado· Aurora, CO

Related Studies