Study of the Effect of Innate on the Inflammatory Response to Endotoxin

Part of paid clinical trials in Research Triangle Park, North Carolina.

Sponsor
National Institute of Environmental Health Sciences (NIEHS)
Study ID
NCT01143480
Status
Recruiting
Apply to this trial

Conditions

  • Asthma
  • Atherosclerosis
  • Cancer
  • Insulin Resistance
  • Metabolic Syndrome

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Study Details

Background: \- Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: \- To examine how specific genes and proteins in blood cells respond to environmental exposures. Eligibility: \- Healthy volunteers between 18 and 45 years of age. Design: * The study will involve one visit of 45 to 60 minutes. * Participants will be screened with a brief physical examination and finger stick to determine if they are eligible to donate blood for the study, and will complete a questionnaire about any medications or other drugs (e.g., cigarettes) they may be taking. * Participants will provide a blood sample for research purposes.

Key Dates

Start date
Jul 30, 2012
Status verified
Mar 2026

Study Design

Enrollment
725 participants (estimated)

Arms

  • Arm: ABCA1
    SNP or allele of interest
  • Arm: APOE
    SNP or allele of interest
  • Arm: APOL1
    SNP or allele of interest
  • Arm: CD14
    SNP or allele of interest
  • Arm: CD44
    SNP or allele of interest
  • Arm: IRGM
    SNP or allele of interest
  • Arm: ITIH3
    SNP or allele of interest
  • Arm: ITIH4
    SNP or allele of interest
  • Arm: MyD88
    SNP or allele of interest
  • Arm: TIRAP
    SNP or allele of interest
  • Arm: TLR4
    SNP or allele of interest
  • Arm: TLR5
    SNP or allele of interest
  • Arm: TNFa
    SNP or allele of interest

Primary Outcome Measure

The primary endpoints of this study are for both cell types and will be levels of 6 cytokines [TNF alpha, IL-6, MIP-2, IL-8, MCP-1, and IFN-beta (ELISA)] induced by LPS and by PAM3CSK4 plus baseline cytokine levels (no exposure to LPS or PAM3CSK... [ Time Frame: After analysis ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
NIEHS Clinical Research Unit (CRU)Research Triangle ParkNorth Carolina27709
NIEHS Join A Study Recruitment Group
[email protected]
855-696-4347

Find similar trials in Research Triangle Park, NC

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
NIEHS Clinical Research Unit (CRU)· Research Triangle Park, NC

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